Green and facile preparation and dual-enhancement cytotoxicity of eupatilin loaded on hollow gold nanoparticles under near-infrared light

Sun, Yiwei; Liang, Hui; Zong, Kunqi; Che, Xin; Meng, Dali

doi:10.1039/d1nj02276h

Cited by 1 publication

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“…Similarly, another group of researchers developed gold nanoparticles for photothermal and chemotherapy based on encapsulation of Eupatilin isolated from Artemisia argyi H.Lév. & Vaniot ( Sun et al, 2021 ) . The nanoparticles were able to permeate through the cytomembrane and locate themselves near the nucleus.…”

Section: Nano-formulations and Green Synthesis: Strategies To Improve...mentioning

confidence: 99%

Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies

et al. 2022

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Endometrial cancer (EC) is the sixth most prevalent type of cancer among women. Kinases, enzymes mediating the transfer of adenosine triphosphate (ATP) in several signaling pathways, play a significant role in carcinogenesis and cancer cells’ survival and proliferation. Cyclin-dependent kinases (CDKs) are involved in EC pathogenesis; therefore, CDK inhibitors (CDKin) have a noteworthy therapeutic potential in this type of cancer, particularly in EC type 1. Natural compounds have been used for decades in the treatment of cancer serving as a source of anticancer bioactive molecules. Many phenolic and non-phenolic natural compounds covering flavonoids, stilbenoids, coumarins, biphenyl compounds, alkaloids, glycosides, terpenes, and terpenoids have shown moderate to high effectiveness against CDKin-mediated carcinogenic signaling pathways (PI3K, ERK1/2, Akt, ATM, mTOR, TP53). Pharmaceutical regimens based on two natural compounds, trabectedin and ixabepilone, have been investigated in humans showing short and midterm efficacy as second-line treatments in phase II clinical trials. The purpose of this review is twofold: the authors first provide an overview of the involvement of kinases and kinase inhibitors in the pathogenesis and treatment of EC and then discuss the existing evidence about natural products’ derived kinase inhibitors in the management of the disease and outline relevant future research.

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Section: Nano-formulations and Green Synthesis: Strategies To Improve...mentioning

confidence: 99%

Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies

et al. 2022

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show abstract

Green and facile preparation and dual-enhancement cytotoxicity of eupatilin loaded on hollow gold nanoparticles under near-infrared light

Abstract: Using NIR irradiation, gold nanomaterials loaded with natural products can achieve targeted release as well as better anti-tumor activity.

Cited by 1 publication

References 32 publications

Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies

Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies

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