Green and efficient synthesis of chiral amines and hydroxylamines by indium (zinc)-copper-mediated alkylation reaction in aqueous media

Synthesis of chiral α,α-disubstituted cyclic nitrones from secondary lactams is reported. The method consists of two stages involving N-oxidation of the lactams and nucleophilic addition to the lactam carbonyls. The N-oxidation of secondary lactams with mCPBA via imidates provides cyclic nitrones with a chiral stereocenter adjacent to the nitrogen atom. A variety of α,α-disubstituted cyclic nitrones were quickly obtained simply by changing organolithium reagents in the nucleophilic addition to N-OSEM lactams.

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Synthesis of Chiral α,α-Disubstituted Cyclic Nitrones from Secondary Lactams

Iwamoto

Tokuyama

Hiraoka

et al. 2023

Bulletin of the Chemical Society of Japan

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Indium Metal-Mediated Reactions in Water: Diverse Synthesis of Important Organic Compounds

Kamboj

Bajpai

Pandey

et al. 2023

COCAT

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Ecofriendly Indium catalyzed synthesis of organic compounds finds various applications in health sectors, electronics, semiconductors, and many more. An efficient co-catalyst and oriented catalyst behavior of Indium has become a choice for many organic transformations. Its compatibility with water, showing nontoxic and nonreactive action, proceeds the reactions with ease. Focus on Indium metal-mediated important organic transformations in water, is visible during the last decades, resulting in diverse organic compounds with excellent yields This present mini-review highlights some important indium metal-mediated reactions in water, for the diverse synthesis of important organic compounds.

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Green and efficient synthesis of chiral amines and hydroxylamines by indium (zinc)-copper-mediated alkylation reaction in aqueous media

Cited by 2 publications

References 36 publications

Synthesis of Chiral α,α-Disubstituted Cyclic Nitrones from Secondary Lactams

Synthesis of Chiral α,α-Disubstituted Cyclic Nitrones from Secondary Lactams

Indium Metal-Mediated Reactions in Water: Diverse Synthesis of Important Organic Compounds

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