Green and cost-effective synthesis of carbon dots from date kernel and their application as a novel switchable fluorescence probe for sensitive assay of Zoledronic acid drug in human serum and cellular imaging

Amin, Niloufar; Afkhami, Abbas; Hosseinzadeh, Leila; Madrakian, Tayyebeh

doi:10.1016/j.aca.2018.05.014

Cited by 90 publications

(44 citation statements)

References 56 publications

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“…The prepared BCDs have potential applications in both biosensors and bioimaging. At the same time, lychee seeds and jujube kernel were also used to prepare BCDs for bioimaging. Then, foods that are commonly eat are also be used, cabbage, winter melon, garlic, allium fistulosum, etc .…”

Section: Applications Of Bcdsmentioning

confidence: 99%

Biomass‐Derived Carbon Dots and Their Applications

Meng

Bai

Wang

et al. 2019

Energy & Environ Materials

332

179

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Carbon dots (CDs) have received much attention due to their superior properties including water solubility, low toxicity, biocompatibility, small size, fluorescence, and ease of modification. The use of a more environmentally friendly method to prepare high‐quality CDs is still an urgent question waiting for solve. The use of renewable, inexpensive, and green biomass resources not only meets the urgent need for large‐scale synthesis biomass CDs (BCDs), but also promotes the development of sustainable applications. In this article, we summarize the representative methods for synthesizing BCDs in green and simple ways using biomass as a carbon source, including hydrothermal carbonization, and microwave, pyrolysis. The prepared BCDs have a uniform particle size distribution and a relatively high throughput, which provide a method to scale up industrial production. Moreover, the integration of specific optical properties, that is, tunable photoluminescence and up‐photoluminescence, has led to remarkable use in bioimaging, sensing, and drug delivery. But the current review is not particularly comprehensive for BCDs. Therefore, we now provide a review focusing on the synthesis, properties, and recent advances in BCDs in biosensing, bioimaging, optoelectronics, and catalytic applications.

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Section: Applications Of Bcdsmentioning

confidence: 99%

Biomass‐Derived Carbon Dots and Their Applications

Meng

Bai

Wang

et al. 2019

Energy & Environ Materials

332

179

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“…Similarly, nitrogen doped NCDs prepared from date kernel by hydrothermal method with Fe 3+ ions proved excellent sensors by detecting trace level sample of zoledronic acid in biological samples by label-free, selective and sensitive off and on signal fluorescence as well as demonstrated good cellular uptake capability. With exceptional water solubility, photo and ionic stability and quantum yield of 12.5 %, the fluorescence intensity of these NCDs were tremendously quenched due to interaction between the functional group of NCDs and ferric ions (fluorescence sensor switch off mode) and after the addition of zoledronic acid, the interaction of its phosphate group with the functional group of NCDs removed the ferric ion from NCDs (fluorescence sensor switch on mode).The developed NCDs-Fe 3+ were potent sensors for zoledronic assay had linearity of 0.1 mM–10.0 mM, precision of 2.70 % detection limit of 0.4 mM with low cytotoxicity and efficient cellular uptake (membrane permeability) as investigated in human osteosarcoma (MG-63) cell line by MTT assay [ 82 ]. Besides, it is because of their efficient fluorescent mechanism CDs/NCDs are observed in endosomal and lysosomal vesicles and the trafficking pathway of the drug loaded CDs/NCDs by transmission electron microscopy (TEM) and confocal microscopy [ 83 ].…”

Section: Applications Of Ncds In Drug Deliverymentioning

confidence: 99%

Natural carbon-based quantum dots and their applications in drug delivery: A review

Nair

Haponiuk

Thomas

et al. 2020

Biomedicine & Pharmacotherapy

169

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Graphical abstract Various NCDs with antimicrobial, anticancer and neurodegenerative drug delivery applications. a) Pleurotus species, b) Hylocereus undatus , c) Curcuma longa L., d) Manilkara zapota (L.) P. Royen , e) Banana leaf, f) Carica papaya , g) Ocimum Sanctum , h) Foeniculum vulgare Mill seeds, i) Azadirachta indica , j) Aloe vera (L.) Burm.f.

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“…Since many enzyme reactions produce H 2 O 2 , the assay has the potential for determining the activities of various enzymes, including glucose oxidase, cholesterol oxidase, and acetylcholinesterase. Quantitation of zoledronic acid (a support medication to treat cancer) was achieved by using nitrogen‐doped C dots quenched by Fe 3+ via electron transfer . Through the interaction of zoledronic acid with the surface Fe 3+ , Fe 3+ ions were released from the C dot surfaces, leading to increased fluorescence.…”

Section: Sensing and Imaging Applicationsmentioning

confidence: 99%

Recent Advances and Sensing Applications of Carbon Dots

2019

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Carbon dots (C dots) with biocompatibility, brightness, stability against photoirradiation and salt, and ease in preparation have become important materials for sensing and imaging. They can be prepared from natural materials and small organic molecules through hydrothermal, microwave‐assistant, and electrochemical methods, with advantages of simplicity and low cost. To enhance the quantum yields of C dots in the red and near‐infrared regions, doping of C dots with heteroatoms such as nitrogen and sulfur has been suggested. C dots both with and without being functionalized recognition elements such as antibodies and aptamers are selective and sensitive for sensing of analytes, including metal ions (e.g., Fe3+, Hg2+, Cu2+), small molecules (e.g., H2O2, cysteine, glutathione), and biopolymers like proteins, as well as for in vitro and in vivo imaging. Depending on the size, charge, and surface ligands of C dots used to label cells, fluorescence images of different organelles are shown. Multicolor images of bacteria, mammalian cells, and plant tissues incubated with C dots are realized when excited at different wavelengths. In this review, many excellent sensing and imaging examples of C dots are presented to highlight their features and to show their challenges for analytical applications.

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Green and cost-effective synthesis of carbon dots from date kernel and their application as a novel switchable fluorescence probe for sensitive assay of Zoledronic acid drug in human serum and cellular imaging

Cited by 90 publications

References 56 publications

Biomass‐Derived Carbon Dots and Their Applications

Biomass‐Derived Carbon Dots and Their Applications

Natural carbon-based quantum dots and their applications in drug delivery: A review

Recent Advances and Sensing Applications of Carbon Dots

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