Green and controllable fabrication of nanocrystals from ionic liquids

Huang, Weizi; Fang, Zhezheng; Zheng, Xianzi; Qi, Jianping; Wu, Wei; Lü, Yi

doi:10.1016/j.cclet.2022.01.043

Cited by 19 publications

(6 citation statements)

References 28 publications

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“…Antisolvent precipitation was used to prepare APZ-HCs. , The preparation was optimized by screening solvent type, stirring speed, and stabilizer concentration (Figure S1). The optimized process was as follows: APZ (50 mg) and P2 (50 μg) were dissolved in 1 mL of dimethyl sulfoxide (DMSO), into which 50 mL of aqueous solution containing 0.2% (w/v) HPMC E5 was poured rapidly under stirring at 700 rpm.…”

Section: Methodsmentioning

confidence: 99%

Establishment of In Vitro Dissolution Based on Similarity with In Vivo Dissolution: A Case Study on Aripiprazole

Man

Yang

et al. 2023

Mol. Pharmaceutics

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In vitro dissolution that predicts the in vivo performance of solid preparations is extremely important in formulation optimization. Fraction absorbed (F a ) has been used to screen in vitro dissolution protocols based on the idea of in vitro−in vivo correlation (IVIVC) but failed to increase the success rate due to the inaccuracy of the F a . The essence of IVIVC is the correlation between in vitro dissolution and in vivo dissolution. We tried to establish in vitro dissolution protocol via similarity with in vivo dissolution using aripiprazole (APZ) as a model drug. Hybrid APZ crystals (APZ-HCs) were prepared by physically embedding aggregation-caused quenching (ACQ) fluorophores inside the lattice to measure the in vivo dissolution. The process did not change the physicochemical properties and crystallinity of APZ. The fluorophore illuminated APZ crystals but was quenched upon dissolution of APZ-HCs in aqueous media, enabling monitoring intact APZ-HCs in real-time. The good correlation between fluorescent quenching and dissolution of APZ-HCs justified reliable quantification of intact APZ crystals. The residual percentage of fluorescence intensity in rats treated by APZ-HCs was recorded with time, which was converted to in vivo dissolution by the difference from 100%. The in vivo dissolution was validated with the F a . The in vitro dissolution profile of APZ was set up via a similarity factor larger than 50 in comparison with the in vivo dissolution. The study provides a novel idea and method to establish in vitro dissolution protocol.

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Section: Methodsmentioning

confidence: 99%

Establishment of In Vitro Dissolution Based on Similarity with In Vivo Dissolution: A Case Study on Aripiprazole

Man

Yang

et al. 2023

Mol. Pharmaceutics

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“…The TD technique requires a significant amount of energy, which can be supplied by high-pressure homogenization, sonication, or shearing. This energy eventually causes fragmentation, resulting in controlled-sized nanoparticles with low polydispersity 24 . For the preparation of nanoparticles using HPH, a premix could be a coarse emulsion, dispersion or suspension 25 .…”

Section: High-pressure Homogenizermentioning

confidence: 99%

The Evolution of Nanocrystalline Drug Delivery System

Nikumbhe,

Bhaskar,

Ola

et al. 2024

J. Drug Delivery Ther.

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Developing nanocrystalline drug delivery technologies is a noteworthy advancement in pharmaceutical science. The nanocrystalline formulations aim to improve therapeutic efficacy, pharmaceutical solubility, and bioavailability. We develop many methods for their fabrication, with top-down, bottom-up, and combination procedures, beginning with reasoning behind nanocrystalline approaches. In this type of review, we focused on the progress of nanocrystalline drug delivery systems in various years by applying different techniques which started in 1990 and what dosage forms are still made by this technology. It is found that various other techniques are also there manufacturing of drug Nanocrystals through years of investigation made by specialists. The researchers found methods such as Top-down, bottom-up, combination, solvent displacement technology, fluidised bed technology, freeze drying, spray drying, electrodynamic technique, and melt emulsification. Every process has advantages and disadvantages, therefore selecting the proper technology is critical to produce drug nanocrystals successfully. Keywords: Nanocrysyals, CT, Bottom-up, Top-Down, HPH, Nanocarriers

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“…Over the past decades, nanocarriers of diverse structures and constituents such as liposomes 46 , 47 , nanocrystals, 48 , 49 , 50 , 51 , 52 carrier-free nanoassemblies, 53 albumin nanoparticles 54 , polymeric micelles 55 , and nanoemulsions 56 have been intensively investigated both in basic research and commercial translation 57 Liposomes (Doxil®, 1995) are the first nanocarriers approved by FDA. The treatment spectra of liposomes have expanded into various diseases with drug payloads covering a range of small molecules and biomacromolecules ( e.g.…”

Section: Emerging Nanocarriersmentioning

confidence: 99%