Green and Black Tea Phenolics: Bioavailability, Transformation by Colonic Microbiota, and Modulation of Colonic Microbiota

Liu, Zhibin; Bruins, Marieke E.; Ni, Li; Vincken, Jean‐Paul

doi:10.1021/acs.jafc.8b02233

Cited by 96 publications

(86 citation statements)

References 44 publications

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“…The microbiota inhabiting the intestinal cavity affects body health by altering the metabolome and regulating the bacterial bioavailability of nutrients in the lumen. ( Johnson et al, 2015 ; Liu et al, 2018 ; Romano et al, 2015 ). In this study, we observed a significant association between the gut microbiota and the variation in BMI and blood lipid levels, which is independent of age.…”

Section: Discussionmentioning

confidence: 99%

Regional distribution of Christensenellaceae and its associations with metabolic syndrome based on a population-level analysis

Li¹,

Li²,

He³

et al. 2020

PeerJ

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The link between the gut microbiota and metabolic syndrome (MetS) has attracted widespread attention. Christensenellaceae was recently described as an important player in human health, while its distribution and relationship with MetS in Chinese population is still unknown. This study sought to observe the association between Christensenellaceae and metabolic indexes in a large sample of residents in South China. A total of 4,781 people from the GGMP project were included, and the fecal microbiota composition of these individuals was characterized by 16S rRNA sequencing and analyzed the relation between Christensenellaceae and metabolism using QIIME (Quantitative Insight Into Microbial Ecology, Version 1.9.1). The results demonstrated that microbial richness and diversity were increased in the group with a high abundance of Christensenellaceae, who showed a greater complexity of the co-occurrence network with other bacteria than residents who lacked Christensenellaceae. The enriched bacterial taxa were predominantly represented by Oscillospira, Ruminococcaceae, RF39, Rikenellaceae and Akkermansia as the Christensenellaceae abundance increased, while the abundances of Veillonella, Fusobacterium and Klebsiella were significantly reduced. Furthermore, Christensenellaceae was negatively correlated with the pathological features of MetS, such as obesity, hypertriglyceridemia and body mass index (BMI). We found reduced levels of lipid biosynthesis and energy metabolism pathways in people with a high abundance of Christensenellaceae, which may explain the negative relationship between body weight and Christensenellaceae. In conclusion, we found a negative correlation between Christensenellaceae and MetS in a large Chinese population and reported the geographical distribution of Christensenellaceae in the GGMP study. The association data from this population-level research support the investigation of strains within Christensenellaceae as potentially beneficial gut microbes.

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Section: Discussionmentioning

confidence: 99%

Regional distribution of Christensenellaceae and its associations with metabolic syndrome based on a population-level analysis

Li¹,

Li²,

He³

et al. 2020

PeerJ

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“…It is generally believed that the bioavailability of phenolic substances in human body is low in comparison to micro and macronutrients, especially for TP (Liu, Bruins, Ni, & Vincken, 2018), because the molecular weight of TP is relatively high and has lots of hydrogen bonds to the hydroxyl group (Warden, Smith, Beecher, Balentine, & Clevidence, 2001). Studies have demonstrated that only a few tea F I G U R E 3 Absorption and biotransformation of tea catechins catechins can be straightly absorbed by small intestine, while most of them (about 80%) may stay in gut and continue to intestinal bacteria metabolism (Warden et al, 2001).…”

Section: Tp Regulate the Bioavailability Of Intestinal Microorganismsmentioning

confidence: 99%

Interactions of tea polyphenols with intestinal microbiota and their implication for cellular signal conditioning mechanism

Gao

Lou

2019

J Food Biochem

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Tea polyphenols (TP) is the main functional substances in tea. It has been reported that TP can modulate the composition of gut microbes in the human body, in addition, after the bio‐transformation by intestinal flora, the metabolites of TP also have positive effects on the health of the host. Lots of researches have shown that TP have possible therapeutic effect against high fat diet induced obesity, which is closely related to the gut flora of the host. Therefore, this review focused on the interactions of TP with intestinal microbiota and their implication for cellular signal conditioning mechanism that will enable us to better study the two‐way effects of TP and intestinal microbiota on host health improvement. Practical applications TP have been widely concerned for their health care properties. As the functional food components, TP have strong antioxidant and physiological activities for human body. A better understanding on the interactions of TP with intestinal microbiota and their implication for cellular signal conditioning mechanism will lead us to better evaluate the contribution of the microbial metabolites of TP, as well as the regulation of intestinal bacterial diversity and abundance for host health.

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“… 11 Recent studies show that dietary intervention with phenolic compounds, most notably those from tea, red wine, or cocoa, promotes a more health-beneficial human gut microbiota composition. 12 − 14 Several in vitro and in vivo studies have indicated that green tea can promote the growth of beneficial bacteria, such as Bifidobacterium and Lactobacillus , and inhibit pathogenic bacteria, such as Clostridium . 15 − 17 …”

Section: Introductionmentioning

confidence: 99%

Reciprocal Interactions between Epigallocatechin-3-gallate (EGCG) and Human Gut Microbiota In Vitro

Liu

Bruijn

Bruins

et al. 2020

J. Agric. Food Chem.

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Interaction of tea phenolics with gut microbiota may play an integral role in the health benefits of these bioactive compounds, yet this interaction is not fully understood. Here, the metabolic fate of epigallocatechin-3-gallate (EGCG) and its impact on gut microbiota were integrally investigated via in vitro fermentation. As revealed by ultrahigh performance liquid chromatography hybrid quadrupole Orbitrap mass spectrometry (UHPLC-Q-Orbitrap-MS), EGCG was promptly degraded into a series of metabolites, including 4-phenylbutyric acid, 3-(3′,4′-dihydroxyphenyl)propionic acid, and 3-(4′-hydroxyphenyl)propionic acid, through consecutive ester hydrolysis, C-ring opening, A-ring fission, dehydroxylation, and aliphatic chain shortening. Microbiome profiling indicated that, compared to the blank, EGCG treatment resulted in stimulation of the beneficial bacteria Bacteroides , Christensenellaceae , and Bifidobacterium . Additionally, the pathogenic bacteria Fusobacterium varium , Bilophila , and Enterobacteriaceae were inhibited. Furthermore, changes in concentrations of metabolites, including 4-phenylbutyric acid and phenylacetic acid, were strongly correlated with changes in the abundance of specific gut microbiota. These reciprocal interactions between EGCG and gut microbiota may collectively contribute to the health benefits of EGCG.

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Green and Black Tea Phenolics: Bioavailability, Transformation by Colonic Microbiota, and Modulation of Colonic Microbiota

Cited by 96 publications

References 44 publications

Regional distribution of Christensenellaceae and its associations with metabolic syndrome based on a population-level analysis

Regional distribution of Christensenellaceae and its associations with metabolic syndrome based on a population-level analysis

Interactions of tea polyphenols with intestinal microbiota and their implication for cellular signal conditioning mechanism

Reciprocal Interactions between Epigallocatechin-3-gallate (EGCG) and Human Gut Microbiota In Vitro

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