Green anchors: Chelating properties of ATRP-click curcumin-polymer conjugates

Averick, Amram; Dolai, Sukanta; Punia, Ashish; Punia, Kamia; Guariglia, Sara R.; Lamoreaux, William J.; Hong, Kunlun; Raja, Krishnaswami

doi:10.1016/j.reactfunctpolym.2016.03.009

Cited by 9 publications

(3 citation statements)

References 15 publications

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“…excellent biocompatibility and strong complexation interactions with heavy metal ions such as Cd 2+ , Cu 2+ and Pb 2+ , the synthesized polymer shows promising applications in processing wastewater. 21 On the other hand, a macromolecular polytriazole was synthesized using a mono-azide compound 15 as presented in Fig. 3 (showing a rod-like cellulose structure) as a substrate through a click reaction.…”

Section: Synthesis Based On the Reaction Between Poly-alkyne And Monomentioning

confidence: 99%

A mini review of the synthesis of poly-1,2,3-triazole-based functional materials

et al. 2017

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Section: Synthesis Based On the Reaction Between Poly-alkyne And Monomentioning

confidence: 99%

A mini review of the synthesis of poly-1,2,3-triazole-based functional materials

et al. 2017

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“…35 The diketone group in curcumin can also be functionalized by interacting with polymers bearing boronic acids 36,37 or complexation with metal ions. 38,39 Because the carrier polymers in drug-polymer conjugates are usually pharmaceutically inactive and only serve as a scaffold, drug loading is limited. 40,41 Higher drug loading can be achieved by directly incorporating curcumin into the polymer's chemical structure, where such poly(pro-drugs) act both as the carrier matrix material and a depot of the drug itself.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Another strategy to enhance the solubility and long-term stability of curcumin is to conjugate the reactive phenol groups to the side chains of polyethylene glycol, , hyaluronic acid, − sodium alginate, or xylan . The diketone group in curcumin can also be functionalized by interacting with polymers bearing boronic acids , or complexation with metal ions. , Because the carrier polymers in drug-polymer conjugates are usually pharmaceutically inactive and only serve as a scaffold, drug loading is limited. , Higher drug loading can be achieved by directly incorporating curcumin into the polymer’s chemical structure, where such poly(pro-drugs) act both as the carrier matrix material and a depot of the drug itself . Curcumin-containing polyacetals, , polyoxalates, polycarbonates, , polyurethane, and polyesters , have been reported, and the release of curcumin from these materials were either rapid (<30 h) or sustained (2–80 days), ,,, depending on the stability of the linker chemistry used to enchain the drug molecules.…”

Section: Introductionmentioning

confidence: 99%

Poly(pro-curcumin) Materials Exhibit Dual Release Rates and Prolonged Antioxidant Activity as Thin Films and Self-Assembled Particles

et al. 2022

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Curcumin is a natural polyphenol that exhibits remarkable antioxidant and anti-inflammatory activities; however, its clinical application is limited in part by its physiological instability. Here, we report the synthesis of curcumin-derived polyesters that release curcumin upon hydrolytic degradation to improve curcumin stability and solubility in physiological conditions. Curcumin was incorporated in the polymer backbone by a one-pot condensation polymerization in the presence of sebacoyl chloride and polyethylene glycol (PEG, M n = 1 kDa). The thermal and mechanical properties, surface wettability, self-assembly behavior, and drug-release kinetics all depend sensitively on the mole percentage of curcumin incorporated in these statistical copolymers. Curcumin release was triggered by the hydrolysis of phenolic esters on the polymer backbone, which was confirmed using a PEGylated curcumin model compound, which represented a putative repeating unit within the polymer. The release rate of curcumin was controlled by the hydrophilicity of the polymers. Burst release (2 days) and extended release (>8 weeks) can be achieved from the same polymer depending on curcumin content in the copolymer. The materials can quench free radicals for at least 8 weeks and protect primary neurons from oxidative stress in vitro. Further, these copolymer materials could be processed into both thin films and self-assembled particles, depending on the solvent-based casting conditions. Finally, we envision that these materials may have potential for neural tissue engineering application, where antioxidant release can mitigate oxidative stress and the inflammatory response following neural injury.

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Interfacial liquid phase-driven removal of copper ions for bioavailable hyperbranched polytriazoles

Ban

Zhuang

et al. 2018

J Mater Sci

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Green anchors: Chelating properties of ATRP-click curcumin-polymer conjugates

Cited by 9 publications

References 15 publications

A mini review of the synthesis of poly-1,2,3-triazole-based functional materials

A mini review of the synthesis of poly-1,2,3-triazole-based functional materials

Poly(pro-curcumin) Materials Exhibit Dual Release Rates and Prolonged Antioxidant Activity as Thin Films and Self-Assembled Particles

Interfacial liquid phase-driven removal of copper ions for bioavailable hyperbranched polytriazoles

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