“Greedy Organs Hypothesis” for sugar and salt in the pathophysiology of non-communicable diseases in relation to sodium-glucose co-transporters in the intestines and the kidney

Itoh, Hiroshi; Tanaka, Masami

doi:10.1016/j.metop.2022.100169

Cited by 7 publications

(10 citation statements)

References 93 publications

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“…The prevalence of hypertension occurs 29% at the age of 25-44 years, at the age of 45-64 years by 51%, and at the age of >65 years by 65%. At the age of 60-64 years, compared to the age of 55-59 years, an increased risk of hypertension occurred by 2.18 times, 65-69 years by 2.45 times and age > 70 years by 2.97 times (Itoh & Tanaka, 2022). In addition to being related to maternal age hypertension, it is also associated with albumin levels.…”

Section: Resultsmentioning

confidence: 93%

Utilizing Go-Yoga Smartphone Application to Prevent Preeclampsia in Pregnant Women

Zakaria

Astuti

2022

j. info kesehat.

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After bleeding, hypertension is the second leading cause of maternal death. Hypertension is caused by a combination of factors, including increased stress and a low level of albumin. All of these changes will cause complications and necessitate long-term medication therapy. As a result, complementary therapies such as family roles and yoga are required. Many people are unfamiliar with yoga movements, so this study provides innovation by incorporating yoga into a smartphone application. The objective of the study is to determine the differences in the implementation of the Go-Yoga smartphone application and the role of the family in pregnant women in the III trimester on blood pressure and albumin levels. This type of research is quasi-experimental involving 60 pregnant women in the third trimester. In Group I, 20 pregnant women practiced yoga with books; in Group II, 20 pregnant women exercised yoga with the Go-Yoga app without their families; and in Group III, 20 pregnant women practiced yoga with their families. The study's results revealed significant blood pressure, with the third group having the highest average (p = 0.000 1). Pregnant women who utilize the Go-Yoga app with their families have lower blood pressure than other groups. Furthermore, pregnant women who employ the Go-Yoga app with their families have higher albumin levels than other groups. Therefore, this study suggests employing the Go-Yoga application with the family prevents hypertension in pregnancy.

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Section: Resultsmentioning

confidence: 93%

Utilizing Go-Yoga Smartphone Application to Prevent Preeclampsia in Pregnant Women

Zakaria

Astuti

2022

j. info kesehat.

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“…Further, it was suggested that the effect of ANP on the intestinal absorption of Na + could be due to the blockade of sodium-glucose cotransporter (SGLT-2) in the intestine ( Gonzalez Bosc et al, 2000 ). In fact, the greedy organs such as kidney and intestine play critical roles in contributing toward hypertension and type-2 diabetes melitus (T2 DM) ( Itoh and Tanaka, 2022 ). These authors suggested that a new type of therapeutic intervention might be necessary for the multigate-greedy organ dysfunction.…”

Section: Nps and Sodium-glucose Cotransporters Inhibitors Mediate Ren...mentioning

confidence: 99%

Guanylyl cyclase/natriuretic peptide receptor-A: Identification, molecular characterization, and physiological genomics

Pandey

2023

Front. Mol. Neurosci.

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The natriuretic peptides (NPs) hormone family, which consists mainly of atrial, brain, and C-type NPs (ANP, BNP, and CNP), play diverse roles in mammalian species, ranging from renal, cardiac, endocrine, neural, and vascular hemodynamics to metabolic regulations, immune responsiveness, and energy distributions. Over the last four decades, new data has transpired regarding the biochemical and molecular compositions, signaling mechanisms, and physiological and pathophysiological functions of NPs and their receptors. NPs are incremented mainly in eliciting natriuretic, diuretic, endocrine, vasodilatory, and neurological activities, along with antiproliferative, antimitogenic, antiinflammatory, and antifibrotic responses. The main locus responsible in the biological and physiological regulatory actions of NPs (ANP and BNP) is the plasma membrane guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA), a member of the growing multi-limbed GC family of receptors. Advances in this field have provided tremendous insights into the critical role of Npr1 (encoding GC-A/NPRA) in the reduction of fluid volume and blood pressure homeostasis, protection against renal and cardiac remodeling, and moderation and mediation of neurological disorders. The generation and use of genetically engineered animals, including gene-targeted (gene-knockout and gene-duplication) and transgenic mutant mouse models has revealed and clarified the varied roles and pleiotropic functions of GC-A/NPRA in vivo in intact animals. This review provides a chronological development of the biochemical, molecular, physiological, and pathophysiological functions of GC-A/NPRA, including signaling pathways, genomics, and gene regulation in both normal and disease states.

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“…Ліпідні ефекти інгібіторів НЗКТГ2 додатково модулюються фоновою терапією інсуліном, іншими протидіабетичними препаратами та статинами [19,33]. Припускають, що інгібітори НЗКТГ2 можуть бути перспективними агентами для пригнічення «жадібних» органів та їх захисту [15].…”

Section: висновкиunclassified

“…Зниження функції мітохондрій не тільки призводить до зниження виробництва АТФ, але й збільшує продукцію активних форм кисню (АФК), що спричиняє дисфункцію органів і старіння організму [8]. Для пояснення патофізіології НІЗ висунуто гіпотезу «жадібних органів» ("greedy organs"), що передбачає надмірне поглинання глюкози та жиру кишківником та посилену реабсорбцію натрію і глюкози нирками (за рахунок глюкозозалежного стимулювання експресії натрій-глюкозних котранспортерів), що веде до гіпертонії та хронічної хвороби нирок, викликає ожиріння та діабет, утворюючи «перехресний зв'язок» між двома органами та двома захворюваннями [15].…”

unclassified

“…Ці стани є складовими метаболічного синдрому (МС, або синдром ІР), який лежить в основі виникнення ЦД2, прогресування атеросклерозу та розвитку хронічної хвороби нирок. Ці патологічні процеси призводять до ниркової недостатності, сліпоти, інсульту, інфаркту міокарда, серцевої недостатності та деменції [15].…”

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MECHANISMS OF THE INFLUENCE OF SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS ON LDL RECEPTOR FUNCTION AND CARDIOVASCULAR RISK IN TYPE 2 DM (literature review)

Кушнарьова

Zinych²,

Kovalchuk³

et al. 2022

RS Global - World Science

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In the modern world, the prevalence of dysmetabolic conditions, which are accompanied by corruption of lipid metabolism and the distribution of adipose tissue in the body, is increasing, and their consequences include cardiovascular diseases, type 2 diabetes mellitus (T2DM) etc. These pathologies are characterized by dyslipidemia, which reflects an imbalance in the processes of assimilation, transportation, absorption and use by fatty acids’ cells as energy and plastic substrates. A decrease in the relative content of unsaturated fatty acids in low-density lipoproteins (LDL) causes dysfunction of cell membranes, and an increase in serum concentration of LDL means corruption of their absorption by cells, which contributes to the development of atherosclerosis. Absorption of LDL by cells occurs through the interaction of apolipoprotein apoE/B-100 with the membrane receptor of LDL. The cell regulates the supply of lipids and cholesterol by synthesizing these receptors. The expression of LDL receptors is regulated at the level of transcription; particularly, it is stimulated by insulin and suppressed by excess cholesterol, the latter leading to abnormal accumulation of lipids in cells and tissues and the development of pathology in various organs. According to clinical and experimental studies and meta-analyses, drugs from the group of inhibitors of sodium-dependent glucose cotransporter-2 (SGLT2) have a pronounced protective cardiorenal effect in patients with T2DM and in cases of kidney and heart dysfunction. These beneficial effects are associated with improving insulin sensitivity, increasing the level of antiatherogenic HDL cholesterol, reducing the accumulation of lipids in visceral fat, stimulating lipolysis, and switching of oxidation towards the preferential use of lipid substrates. The paradoxical increase in LDL cholesterol is mainly due to less atherogenic large floating particles, and the negative effect is apparently counterweight by the wide range of beneficial pleiotropic effects of gliflozins.

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“Greedy Organs Hypothesis” for sugar and salt in the pathophysiology of non-communicable diseases in relation to sodium-glucose co-transporters in the intestines and the kidney

Cited by 7 publications

References 93 publications

Utilizing Go-Yoga Smartphone Application to Prevent Preeclampsia in Pregnant Women

Utilizing Go-Yoga Smartphone Application to Prevent Preeclampsia in Pregnant Women

Guanylyl cyclase/natriuretic peptide receptor-A: Identification, molecular characterization, and physiological genomics

MECHANISMS OF THE INFLUENCE OF SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS ON LDL RECEPTOR FUNCTION AND CARDIOVASCULAR RISK IN TYPE 2 DM (literature review)

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