Greater Three‐Dimensional Ventricular Lead Tip Separation is Associated with Improved Outcome after Cardiac Resynchronization Therapy

Abstract

Greater three-dimensional separation of LV-to-RV leads is associated with improved response to CRT. A prospective multicenter trial is needed to assess lead separation as a predictor for response.

Sex Differences in Device Therapy for Heart Failure: Utilization, Outcomes, and Adverse Events

“…25,53,54,57,64,71 There were no differences between sexes on improvement in NYHA class. Regarding LVESV, women did, however, have an overall higher proportion of LVESV reduction (risk ratio = 1.12 [95% CI: 0.99-1.26]) (Fig.…”

2012 ACCF/AHA/HRS Focused Update of the 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities

“…For example, wider LVright ventricular lead separation has been shown to provide better results. 50 A subanalysis of MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy) 20 showed that an apical LV lead position, as compared with a basal or midventricular position, resulted in a significant increased risk for HF or death. 51 Clinical trials of resynchronization included mainly patients in sinus rhythm.…”

2012 ACCF/AHA/HRS Focused Update Incorporated Into the ACCF/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities

“…For example, wider LV-right ventricular lead separation has been shown to provide better results. 577 A subanalysis of MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy) 546 showed that an apical LV lead position, as compared with a basal or midventricular position, resulted in a significant increased risk for HF or death. 578 Clinical trials of resynchronization included mainly patients in sinus rhythm.…”