Greater than predicted decrease in resting energy expenditure with age: cross-sectional and longitudinal evidence

Alfonzo-González, G; Doucet, Éric; Bouchard, Claude; Tremblay, Angelo

doi:10.1038/sj.ejcn.1602262

Cited by 24 publications

(8 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cross‐sectional and longitudinal evidence from Alfonzo‐Gonzalez et al. confirms that resting EE is affected by age independent of changes in body composition and that this decrease is more pronounced in early adulthood in men but in the later years of women (42).…”

Section: Discussionmentioning

confidence: 92%

Relative changes in resting energy expenditure during weight loss: a systematic review

2010

View full text Add to dashboard Cite

A more comprehensive understanding of the effects of weight loss on the changes in resting energy expenditure (EE) is relevant. A MEDLINE search was performed to identify studies with information relevant to this systematic review. From this search, the mean rate of resting EE decrease relative to weight loss was calculated from 90 available publications. A decrease of resting EE relative to weight loss of -15.4 +/- 8.7 kcal kg(-1) was observed from 2977 [corrected] subjects. No sex differences were noted in the overall resting EE decrease relative to weight loss. However, a significant sex differences was seen with pharmacological interventions, which seemed to depress the resting EE relative to weight loss to a greater extent in men than in women (P < 0.05). A greater drop in resting EE relative to weight loss was observed for short interventions (more than 2 but less than 6 weeks) when compared with long interventions (<6 weeks) (-27.7 +/- 6.7 vs. -12.8 +/- 7.1 kcal kg(-1)) (P < 0.001). Men and women have a similar decrease in resting EE relative to weight loss except in the case of pharmacological interventions. Short interventions also produced greater resting EE losses relative to weight loss.

show abstract

Section: Discussionmentioning

confidence: 92%

Relative changes in resting energy expenditure during weight loss: a systematic review

2010

View full text Add to dashboard Cite

show abstract

“…Age-related declines in resting energy expenditure are not observed among those women that exercise regularly [ 89 ]. Thus, continuous physical activity during the mid-life may be an efficacious strategy to counteract the age-related [ 166 ] and menopause-related decreases [ 89 ] in resting energy expenditure and prevent weight gain and abdominal adiposity deposition. In fact, a recently published meta-analysis of 8 walking intervention studies among peri- and postmenopausal women demonstrated statistically significant improvements in BMI, body weight, and body fat percentage as compared to no-exercise groups [ 167 ].…”

Section: Implications For Therapymentioning

confidence: 99%

Association of Mid-Life Changes in Body Size, Body Composition and Obesity Status with the Menopausal Transition

2016

View full text Add to dashboard Cite

The mid-life period is a critical window for increases in body weight and changes in body composition. In this review, we summarize the clinical experience of the menopausal transition by obesity status, and examine the evidence regarding the menopausal transition and reproductive hormones effects on body weight, body composition, or fat distribution. Mid-life obesity is associated with a different menopausal experience including associations with menstrual cycle length prior to the final menstrual period (FMP), age at the FMP, and higher prevalence of vasomotor symptoms. The menopausal transition is associated with weight gain and increased central body fat distribution; the majority of evidence suggests that changes in weight are due to chronological aging whereas changes in body composition and fat distribution are primarily due to ovarian aging. Continuous and regular physical activity during mid-life may be an efficacious strategy to counteract the age-related and menopause-related changes in resting energy expenditure and to prevent weight gain and abdominal adiposity deposition.

show abstract

“…As described by the investigators, this large metabolic adaptation could not be attributed to the fact that RMR was measured with a different calorimeter 6 years after the end of the competition. Additionally, our research experience reveals that the reported persistent metabolic adaptation can only be partly attributable to an aging effect over a 6‐year follow‐up .…”

mentioning

confidence: 78%

Metabolic adaptation: Here to stay?

Tremblay

2016

Obesity

View full text Add to dashboard Cite

It is well established that substantial body fat loss in individuals with obesity can induce a state of metabolic vulnerability potentially favoring long-term weight regain. This is explained by a greater than predicted decrease in energy expenditure and an increase in appetite that are associated with biological adaptations such as reduced leptinemia and sympathetic nervous system activity (1,2). However, despite the numerous research attempts to determine whether cycles of weight loss/regain may generate persistent metabolic vulnerability, this question has never been clearly answered and remains a significant matter of preoccupation for health professionals and individuals with obesity.In this issue of Obesity, Fothergill et al. (3) report a study that gave the opportunity to test participants of "The Biggest Loser" in whom resting metabolic rate (RMR) was measured before and after the competition as well as 6 years later. As expected, the mean 58.3 kg weight loss observed during the competition resulted in a substantial decrease in RMR that reached 610 kcal/day. These investigators also estimated that this decrease included a metabolic adaptation of 275 kcal/day representing a decrease exceeding what would have been predicted by the loss of fat mass and fat-free mass. Six years after the end of the competition, this decrease in adaptive thermogenesis was even more pronounced. The mean metabolic adaptation had increased to 499 kcal/day, which explains why RMR remained 704 kcal/day below the baseline level despite a 41 kg body weight regain. As described by the investigators, this large metabolic adaptation could not be attributed to the fact that RMR was measured with a different calorimeter 6 years after the end of the competition. Additionally, our research experience reveals that the reported persistent metabolic adaptation can only be partly attributable to an aging effect over a 6-year follow-up (4).Globally, the results of this study are well concordant with previous long-term studies having shown that substantial weight loss induces biological adaptations that promote weight regain (1,2). Beyond these observations, the results of this study add bad news to this story which is related to the amplification of the metabolic adaptation over time. From a clinical standpoint, this should be viewed as an important argument in favor of the inclusion of weight maintenance periods within a weight-reducing program that could reveal that a healthy sustainable body weight is achieved and that striving for maximal weight loss is not relevant. Finally, the reported thermogenic adaptation over time also reminds us that the metabolic vulnerability of individuals with obesity persists even after their condition has supposedly been cured by weight loss.O

show abstract

Greater than predicted decrease in resting energy expenditure with age: cross-sectional and longitudinal evidence

Cited by 24 publications

References 33 publications

Relative changes in resting energy expenditure during weight loss: a systematic review

Relative changes in resting energy expenditure during weight loss: a systematic review

Association of Mid-Life Changes in Body Size, Body Composition and Obesity Status with the Menopausal Transition

Metabolic adaptation: Here to stay?

Contact Info

Product

Resources

About