Greater than normal variability of ca-induced ca release in muscle fibers of a patient with a positive family history of malignant hyperthermia

A Malignant Hyperthermialike Episode in a Liver Transplant Recipient

“…To definitively diagnose a case of malignant hyperthermia, the Ca2+-induced Ca2+-release test using skinned fibers from skeletal muscle is performed. 5 However, as informed consent for the Ca2+-induced Ca2+-release test could not be obtained Abbreviations: ALT, alanine aminotransaminase; AMPC, ampicillin sodium; AST, aspartate aminotransferase; ATIII, antithrombin III; BE, base excess: endtidal partial pressure of CO 2 ; BP, systolic (diastolic) blood pressure; BT, core body temperature; CO, cardiac output; CPK, serum creatine phosphokinase; CTM, cefotaxime sodium; HR, heart rate; sys (dia); Mb, serum myoglobin; PC, platelet concentrate; S v O 2 , mixed venous oxygen saturation; VO 2 , oxygen consumption Body temperature continued to rise and exceeded 38.0°C, even with surface cooling. The total blood loss was 2990 mL (containing a large volume of ascites); 8450 mL of crystalloid solution, 3000 mL of colloid solution, and 10 units of platelets were administered.…”