Greater Susceptibility to Mycobacterium johnei of C.57 Black Mice, when compared with CBA and Swiss White Mice

An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a ''best fit'' JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host-pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters. #

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Encephalopathy in Mice Produced by Inoculation With Scrapie Brain Material

Chandler

1961

The Lancet

455

199

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Greater Susceptibility to Mycobacterium johnei of C.57 Black Mice, when compared with CBA and Swiss White Mice

Cited by 5 publications

References 4 publications

The virulence of Mycobacterium avium and related mycobacteria for C57 mice

The virulence of Mycobacterium avium and related mycobacteria for C57 mice

Experimental challenge models for Johne's disease: A review and proposed international guidelines

Encephalopathy in Mice Produced by Inoculation With Scrapie Brain Material

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