Greater Skeletal Muscle Oxidative Capacity Is Associated With Higher Resting Metabolic Rate: Results From the Baltimore Longitudinal Study of Aging

Zampino, Marta; Semba, Richard D.; Adelnia, Fatemeh; Spencer, Richard G.; Fishbein, Kenneth W.; Schrack, Jennifer A.; Simonsick, Eleanor M.; Ferrucci, Luigi

doi:10.1093/gerona/glaa071

Cited by 25 publications

(14 citation statements)

References 42 publications

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“…Efficient mitochondria in skeletal muscle are important for maintaining higher energy expenditure rates 125,126 . Chronic PM 2.5 exposure induces permanent functional changes in muscle mitochondria 80 .…”

Section: Pm25 Impairs Skeletal Muscle Fitnessmentioning

confidence: 99%

Fine particulate matter induces adipose tissue expansion and weight gain: Pathophysiology

Guardia

2023

Obesity Reviews

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Dysregulations in energy balance represent a major driver of obesity. Recent evidence suggests that environmental factors also play a pivotal role in inducing weight gain. Chronic exposure to fine particulate matter (PM 2.5 ) is associated with white adipose tissue (WAT) expansion in animals and higher rates of obesity in humans.This review discusses metabolic adaptions in central and peripheral tissues that promote energy storage and WAT accumulation in PM 2.5 -exposed animals and humans. Chronic PM 2.5 exposure produces inflammation and leptin resistance in the hypothalamus, decreasing energy expenditure and increasing food intake. PM 2.5 promotes the conversion of brown adipocytes toward the white phenotype, resulting in decreased energy expenditure. The development of inflammation in WAT can stimulate adipogenesis and hampers catecholamine-induced lipolysis. PM 2.5 exposure affects the thyroid, reducing the release of thyroxine and tetraiodothyronine. In addition, PM 2.5 exposure compromises skeletal muscle fitness by inhibiting Nitric oxide (NO)-dependent microvessel dilation and impairing mitochondrial oxidative capacity, with negative effects on energy expenditure. This evidence suggests that pathological alterations in the hypothalamus, brown adipose tissue, WAT, thyroid, and skeletal muscle can alter energy homeostasis, increasing lipid storage and weight gain in PM 2.5 -exposed animals and humans. Further studies will enrich this pathophysiological model.

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Section: Pm25 Impairs Skeletal Muscle Fitnessmentioning

confidence: 99%

Fine particulate matter induces adipose tissue expansion and weight gain: Pathophysiology

Guardia

2023

Obesity Reviews

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“…In brief, elevated peripheral oxidative capacity is thought to be one of the strongest predictors of whole-body-IS in virtue of a higher total substrate utilization ( Bruce et al, 2003 ). A recent study of Zampino et al (2020) highlighted the influence of SM OXPHOS activity on resting metabolic rate, independently of total FFM, which suggests that intrinsic SM OXPHOS capacity is a stronger driver of energy expenditure than SM quantity ( Zampino et al, 2020 ). Nonetheless, whether exercise-induced SM hypertrophy leads to significant mitochondrial adaptations with regards to improved IS remains unclear.…”

Section: Narrative Literature Reviewmentioning

confidence: 99%

Exercising for Insulin Sensitivity – Is There a Mechanistic Relationship With Quantitative Changes in Skeletal Muscle Mass?

et al. 2021

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Skeletal muscle (SM) tissue has been repetitively shown to play a major role in whole-body glucose homeostasis and overall metabolic health. Hence, SM hypertrophy through resistance training (RT) has been suggested to be favorable to glucose homeostasis in different populations, from young healthy to type 2 diabetic (T2D) individuals. While RT has been shown to contribute to improved metabolic health, including insulin sensitivity surrogates, in multiple studies, a universal understanding of a mechanistic explanation is currently lacking. Furthermore, exercised-improved glucose homeostasis and quantitative changes of SM mass have been hypothesized to be concurrent but not necessarily causally associated. With a straightforward focus on exercise interventions, this narrative review aims to highlight the current level of evidence of the impact of SM hypertrophy on glucose homeostasis, as well various mechanisms that are likely to explain those effects. These mechanistic insights could provide a strengthened rationale for future research assessing alternative RT strategies to the current classical modalities, such as low-load, high repetition RT or high-volume circuit-style RT, in metabolically impaired populations.

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“…A gradual decline in RMR and TDEE is associated with advancing age, diminished lean mass, energy restriction and weight loss [ 8 , 31 , 32 , 33 ]. Age-induced declines in RMR may be attributed to alterations of organ and tissue masses and diminished fat free mass (FFM) which accounts for the magnitude of resting metabolism [ 3 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Measured Resting Metabolic Rate for Dietary Prescription in Ageing Adults with Overweight and Adiposity-Based Chronic Disease

et al. 2021

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The primary objective of this study was to compare weight changes in two groups of ageing Irish adults with overweight and adiposity-based chronic disease: participants who had dietary energy requirements prescribed on the base of measured RMR and participants whose RMR was estimated by a prediction equation. Fifty-four Caucasian adults (male n = 25; female n = 29, age 57.5 ± 6.3 years, weight 90.3 ± 15.1 kg, height 171.5 ± 9.5 cm, BMI 30.7 ± 4.6 kg/m2) were randomly assigned to a dietary intervention with energy prescription based on either measured RMR or estimated RMR. RMR was measured by indirect calorimetry after an overnight fast and predicted values were determined by the Mifflin et al. (1990) prediction equation. All participants received individual nutritional counselling, motivational interviewing and educational material. Anthropometric variables, blood pressure, blood glucose and blood lipid profile were assessed over 12 weeks. Body weight at week 12 was significantly lower (p < 0.05) for both groups following dietary interventions, mRMR: −4.2%; eRMR: −3.2% of initial body weight. There was no significant difference in weight loss between groups. Overall, 20.8% mRMR and 17.4% of eRMR participants experienced clinically meaningful (i.e., ≥5% of initial weight) weight reduction. Weight reduction in adults aged ≥50 years over the short term (12 weeks) favoured a reduction in blood pressure, triglycerides and glucose, thus reducing cardiovascular disease risk factors. This research indicates that employing a reduced-calorie diet using indirect calorimetry to determine energy needs when improving weight outcomes in adults (>50 years) with overweight and adiposity-based chronic disease is equal to employing a reduced-calorie diet based on the Mifflin et al. (1990) prediction equation. A reduced-energy diet based on mRMR or eRMR facilitates clinically meaningful weight reduction in adults (≥50 years) over the short term (12 weeks) and favours a reduction in blood pressure, triglycerides and glucose, thus reducing cardiovascular disease risk factors. Moreover, the addition of motivational interviewing and behaviour change techniques that support and encourage small behaviour changes is effective in short-term weight management.

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Greater Skeletal Muscle Oxidative Capacity Is Associated With Higher Resting Metabolic Rate: Results From the Baltimore Longitudinal Study of Aging

Cited by 25 publications

References 42 publications

Fine particulate matter induces adipose tissue expansion and weight gain: Pathophysiology

Fine particulate matter induces adipose tissue expansion and weight gain: Pathophysiology

Exercising for Insulin Sensitivity – Is There a Mechanistic Relationship With Quantitative Changes in Skeletal Muscle Mass?

Evaluation of Measured Resting Metabolic Rate for Dietary Prescription in Ageing Adults with Overweight and Adiposity-Based Chronic Disease

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