Greater Efficiency of Human Growth Hormone Therapy in Children below Five Years of Age with Growth Hormone Deficiency

Josefsberg, Z; Bauman, B; Pertzelan, A; Laron, Zvi

doi:10.1159/000180800

Cited by 14 publications

(9 citation statements)

References 16 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No significant differences were observed between patients with IGHD or MPD in terms of birth length or characteristics at diagnosis. The analysis of large cohorts of treated GHD patients has revealed several variables influencing outcome (3-6), among them age at onset of treatment (4,5,8,11). In these series, the height gain at final height averages þ0.9 (3) to þ1.7 (11) SDS and compares very unfavorably with our results (þ3.1 SDS at current height).…”

Section: Discussionsupporting

confidence: 79%

“…Earlier reports have indicated favorable outcomes in GHD patients treated before the age of 5 years. However, the number of patients in these series was often small and the age range at initiation of treatment was broad with a mean of 3 years (8)(9)(10)(11)(12). Two prospective studies (13,14) recently reported early onset of GH treatment (mean 1.5 years of age) in GHD patients, allowing a rapid catch-up growth during the first year of treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long-term results of GH therapy in GH-deficient children treated before 1 year of age

Huet

Jc²,

Nivelon³

et al. 1999

European Journal of Endocrinology

View full text Add to dashboard Cite

Objectives: To evaluate the long-term effects of GH therapy in early diagnosed GH-deficient patients treated before 1 year of age. Study design: We studied all 59 patients (33 males) recorded by Association France-Hypophyse and treated with GH (0.50 Ϯ 0.15 IU/kg (S.D.) per week) before 1 year of age. Clinical presentation and growth parameters under GH treatment were analyzed. Results: Neonatal manifestations of hypopituitarism were frequent: hypoglycemia (n ¼ 50), jaundice (n ¼ 25) and micropenis (n ¼ 17/33). Although birth length was moderately reduced (¹0.9 Ϯ 1.4), growth retardation at diagnosis (5.8 Ϯ 3.8 months) was severe (¹3.5 Ϯ 1.9 standard deviation scores (SDS)). Fifty patients (85%) had thyrotropin and/or corticotropin deficiency. After a mean duration of GH therapy of 8.0 Ϯ 3.6 years, change in height SDS was þ3:11 Ϯ 2:06 S.D., exceeding 4 SDS in 19 patients. Only 9 patients (15%) did not reach a height of ¹2 S.D. for chronological age and 20 patients (34%) exceeded their target height. Pretreatment height SDS was independently associated with total catch-up growth. Conclusion: Conventional doses of GH allow normalization of height in patients with early GH deficiency and treatment.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Long-term results of GH therapy in GH-deficient children treated before 1 year of age

Huet

Jc²,

Nivelon³

et al. 1999

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…The study population, however, contained only a minority of children who started treat ment at a very young age. The short-term response in these children is better [4],…”

Section: Discussionmentioning

confidence: 95%

Final Height in a Large Cohort of Dutch Patients with Growth Hormone Deficiency Treated with Growth Hormone

Rikken

Wit

1995

Horm Res

View full text Add to dashboard Cite

Final height was evaluated in 203 patients with growth hormone (GH) deficiency, who had been treated with GH in childhood, and was related to other factors. Mean final height was 168.1 cm (men) and 154.7 cm (women), -2.07 and -2.20 SD of the population mean, respectively. Patients with GH deficiency due to cerebral tumour were taller than those with idiopathic GH deficiency, and patients with induced puberty were taller than those with spontaneous puberty. Target height (r = +0.37), birth length (r = 0.36), height SDS at the start of therapy (r = +0.51) and at the start of puberty (r = +0.58) were significantly correlated with final height. Multiple linear regression analysis revealed that after correction for height at the start of puberty, age at the start of puberty was also positively correlated with final height. Patients who were treated after 1983 (when treatment regimens were changed) were taller than patients who finished treatment before 1983. The results suggest the importance of preventing a large initial height deficit and attaining optimal height at the start of puberty.

show abstract

“…Another report, from Josefsberg et al [11] gave the results obtained after 2-5 years of treatment with hGH 2-4 IU 3 times/week, increased to 4-6 IU 3 times/week when the growth rate declined. The authors compared two groups of hypopituitary children: 21 whose treat ment started at age 0.7-4.8 years (14 isolated and 7 mul tiple deficiencies) and 18 whose treatment started be tween 5.2 and 9.9 years (10 isolated and 7 multi-defi cient).…”

Section: Results Of Treatment With Gh In Very Young Hypopituitary Patmentioning

confidence: 97%

Early Diagnosis and Early Treatment of Growth Hormone Deficiency

Job

1989

Horm Res

View full text Add to dashboard Cite

In the past, growth hormone (GH) deficiency has usually been diagnosed too late in dwarfed children, so that substitution therapy was not able to obtain a final height in the normal range for most of them. Complete catch-up of growth in hypopituitary patients needs early diagnosis and early treatment. This requires: (1) that full attention be paid to any insufficiency of length or height increment in infants and young children; (2) that evaluation of GH secretion be performed in spite of the practical difficulties encountered in small patients, and (3) that the interpretation of hormonal measurements be carefully discussed. Though the overall results obtained to date in treating very young GH-deficient children have not been completely satisfactory, it is certain that those whose height was within or near the limits of-2 SD at the onset of treatment maintained a normal height. The relationship of end results with the doses of GH used remains to be investigated. Future results will probably be improved more by earlier diagnosis and by using daily injections than by an increase in the annual dose of GH.

show abstract

Greater Efficiency of Human Growth Hormone Therapy in Children below Five Years of Age with Growth Hormone Deficiency

Cited by 14 publications

References 16 publications

Long-term results of GH therapy in GH-deficient children treated before 1 year of age

Long-term results of GH therapy in GH-deficient children treated before 1 year of age

Final Height in a Large Cohort of Dutch Patients with Growth Hormone Deficiency Treated with Growth Hormone

Early Diagnosis and Early Treatment of Growth Hormone Deficiency

Contact Info

Product

Resources

About