Greater celandine (Chelidonium majus L.) for COVID‐19: A twenty‐case series

Abstract

Wuhan, China, with a rapid increase in cases worldwide. Until now, among several drugs tested, none demonstrated sufficient efficacy for its etiological treatment.Greater celandine (Chelidonium majus L.) is a well-known medicinal plant, traditionally indicated for digestive disorders and topically to remove warts. This study, performed at private offices in São Paulo and Aracaju (Brazil), describes 20 consecutive COVID-19 outpatients treated with greater celandine and their clinical evolution. The patients, aged 14-71 years (median of 41 years), were treated with Chelidonium majus 10% mother tincture, 20-30 drops three times a day for 3-12 days (median of 5 days). Clinical features were assessed during the treatment and at least until 1 week after its end. These cases were considered mild, as most COVID-19 cases.The symptoms were mainly fever, fatigue, cough, sore throat, coryza, anosmia, ageusia, and headache. Ten patients had comorbidities, such as hypertension, diabetes, and overweight. Complete or almost complete clinical improvement occurred within 1-9 days of treatment (median of 3 days). There were no adverse events. This casuistry, although small, may inspire other researchers to continue investigating Chelidonium majus as a healing treatment for COVID-19.

Anticancer, Anticoagulant, Antioxidant and Antimicrobial Activities of Thevetia peruviana Latex with Molecular Docking of Antimicrobial and Anticancer Activities

“…Antiviral activity indicated that latex extracts had inhibitor potential not only for plant viruses but also toward human viruses including HPV, HSV-1, and HIV [ 10 ]. Recently, Gardin and Braga [ 11 ] used latex of Chelidonium majus to treat infection in humans exposed to severe acute respiratory syndrome coronavirus-2; the recovery level was observed after three days of latex administration. Gracz-Bernaciak et al [ 12 ] assumed that latex proteins—alongside certain alkaloids—were responsible for antiviral activity.…”

Phytocompounds and COVID‐19: Two years of knowledge

“…A placebo‐controlled study showed that a syrup containing propolis and Hyoscyamus niger L. extract ameliorated the signs and symptoms of COVID‐19 (Kosari et al, 2021 ). Finally, Chelidonia majus , a plant of the Papaveraceae family containing isoquinoline alkaloids, was believed to be a promising approach for the treatment of COVID‐19, based on a 20‐case series (Gardin & Braga, 2021 ).…”

Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway

“…Chelidonium majus L. is an important medical plant and has a long history of being used in the treatment of many diseases (e.g., infective diseases, cancer, chronic bronchitis, and liver disorders) in China and several European countries [ 5 ]. It has been reported that the extracts of Chelidonium majus L. possess a broad range of biological functions, such as anticancer, anti-inflammatory, antioxidant, antibacterial, immune regulation, and others [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. However, recent findings show that the extract of Chelidonium majus L. may cause potential hepatotoxicity in humans and animals [ 12 , 13 ].…”