Greater adherence to a Mediterranean diet is associated with lower prevalence of colorectal adenomas in men of all races

Haslam, Alyson; Robb, Sara Wagner; Hébert, James R.; Huang, Hanwen; Ebell, Mark H.

doi:10.1016/j.nutres.2017.10.003

Cited by 16 publications

(21 citation statements)

References 27 publications

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“…Among the factors related to CRC risk, obesity, physical activity, inflammation and dietary habits have been suggested to play an important role. A diet with a high intake of dietary fiber, vegetables and fruits has been associated not only with a lower incidence of CRC onset [3,4] but also to improve the overall survival in patients with this disease [38]. In the present study, maslinic acid at 5 mg/kg already exerted a chemopreventive activity, and this low dose could be accomplished following a diet rich in foods containing a high amount of this compound.…”

Section: Discussionmentioning

confidence: 64%

“…Colorectal cancer (CRC) is one of the most frequent malignancies in the world, ranking third in incidence and second in mortality in both genders [1]. Epidemiological studies support that lifestyle along with nutritional interventions can prevent CRC and that Mediterranean diet is associated with a lower prevalence of this disease in humans of all races [2,3,4]. This eating pattern is characterized by a high consumption of fruits, vegetables and legumes that provides a plethora of bioactive compounds with antitumoral activity [2,3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiological studies support that lifestyle along with nutritional interventions can prevent CRC and that Mediterranean diet is associated with a lower prevalence of this disease in humans of all races [2,3,4]. This eating pattern is characterized by a high consumption of fruits, vegetables and legumes that provides a plethora of bioactive compounds with antitumoral activity [2,3,4]. Among them, stand out resveratrol contained in grapes [5], sulforaphane in cruciferous vegetables [6] or luteolin in celery and parsley [7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Reduction of Preneoplastic Lesions Induced by 1,2-Dimethylhydrazine in Rat Colon by Maslinic Acid, a Pentacyclic Triterpene from Olea europaea L.

et al. 2019

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Maslinic acid triggers compelling antiproliferative and pro-apoptotic effects in different human cancer cell lines. Hence, the chemopreventive activity was investigated on early stages of carcinogenesis induced by 1,2-dimethylhydrazine (DMH) which is a model that mimics human sporadic colorectal cancer. Male Sprague-Dawley rats were orally administered either maslinic acid at 5, 10 or 25 mg/kg dissolved in (2-hydroxypropyl)-β-cyclodextrin 20% (w/v) or the solvent for 49 days. After one week of treatment, animals received three weekly intraperitoneal injections of DMH at the dose of 20 mg/kg. Maslinic acid reduced the preneoplastic biomarkers, aberrant crypt foci (ACF) and mucin-depleted foci (MDF), already at 5 mg/kg in a 15% and 27%, respectively. The decline was significant at 25 mg/kg with decreases of 33% and 51%, respectively. Correlation analysis showed a significant association between the concentrations of maslinic acid found in the colon and the reduction of ACF (r = 0.999, P = 0.019) and MDF (r = 0.997, P = 0.049). The present findings demonstrate that maslinic acid induced an inhibition of the initiation stages of carcinogenesis. The assessment of this pentacyclic triterpene at the colon sheds light for designing diets with foods rich in maslinic acid to exert a chemopreventive activity in colorectal cancer.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reduction of Preneoplastic Lesions Induced by 1,2-Dimethylhydrazine in Rat Colon by Maslinic Acid, a Pentacyclic Triterpene from Olea europaea L.

et al. 2019

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“…The additional benefits conferred upon Blacks following a largely plant-based diet were recorded in a separate cohort study of colorectal cancer and diet in men. Black men who had higher diet scores (indicating a more plant-based diet) had even lower odds of colorectal adenomas than did White men with similar scores [134]. Both of these results suggest that a shift to plant-based diets may offer even greater benefits for Blacks than for Whites.…”

Section: Findings From the Regards Study And Othersmentioning

confidence: 90%

The Potential for Plant-Based Diets to Promote Health Among Blacks Living in the United States

Sterling

2019

Nutrients

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Plant-based diets are associated with reduced risks of various chronic diseases in the general population. However, it is unclear how these benefits translate to Blacks living in the United States, who are disproportionately burdened with heart disease, cancer, diabetes, obesity, and chronic kidney disease. The objectives of this study were to: (1) review the general evidence of plant-based diets and health outcomes; (2) discuss how this evidence translates to Blacks following a plant-based diet; and (3) provide recommendations and considerations for future studies in this area. Interestingly, although the evidence supporting plant-based diets in the general population is robust, little research has been done on Blacks specifically. However, the available data suggests that following a plant-based diet may reduce the risk of heart disease and possibly cancer in this population. More research is needed on cardiovascular disease risk factors, cancer subtypes, and other chronic diseases. Further, attention must be given to the unique individual, familial, communal, and environmental needs that Blacks who follow plant-based diets may have. Interventions must be culturally appropriate in order to achieve long-term success, and providing low-cost, flavorful, and nutritious options will be important.

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“…The lion's share of the studies underlines the significant role of the Mediterranean dietary pattern in preventing cardiovascular diseases [9], type II Diabetes [10], obesity and metabolic syndrome [11,12]. Moreover, increased interest in the diet's results on human morbidities underscores the effect of prolonged survival of the Elderly [13], better sleep and academic performance in teens [14], increased vitamin D levels, improvement of neck bone mineral density in adults who already had osteoporosis [15], longer length of telomeres in women [16], decreased depression in the Elderly [17], lower risk of fatty liver [18], lower risk of aggressive prostate cancer [19], prevention of colon cancer [20], reduced incidence of gestational diabetes and premature births [21], longevity [22], and improvement of arthritis symptoms [7].…”

Section: Special Features Of the Mediterranean Diet And Links To Disementioning

confidence: 99%

Interplay between Mediterranean Diet and Gut Microbiota in the Interface of Autoimmunity: An Overview

Tsigalou¹,

Tsolou²,

Konstantinidis³

et al. 2020

Preprint

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The nutritional habits regulate the gut microbiota and may provoke and/or prevent autoimmune disease. Western diet is rich in sugars, meat and poly-unsaturated fatty acids, which lead to dysbiosis of intestinal microbiota, disruption of gut epithelial barrier and chronic mucosal inflammation. On the other hand, Mediterranean Diet (MedDiet) is rich in ω3 fatty acids, fruits and vegetables and has anti-inflammatory properties, which can restore gut eubiosis. The effect of MedDiet and its components in health and disease states have been thoroughly analyzed in several studies. Moreover, several studies have specifically investigated the association between MedDiet, microbiota and risk for autoimmune diseases. Furthermore, the MedDiet has been associated with lower risk of cardiovascular diseases, which plays a critical role in reducing mortality in patients suffering from autoimmune diseases with comorbidities. The aim of the present review is to specifically highlight current knowledge regarding possible interactions of MedDiet with the patterns of intestinal microbiota focusing on autoimmunity and a blueprint through dietary modulations for the prevention and management of diseases’s activity and progression.

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Greater adherence to a Mediterranean diet is associated with lower prevalence of colorectal adenomas in men of all races

Cited by 16 publications

References 27 publications

Reduction of Preneoplastic Lesions Induced by 1,2-Dimethylhydrazine in Rat Colon by Maslinic Acid, a Pentacyclic Triterpene from Olea europaea L.

Reduction of Preneoplastic Lesions Induced by 1,2-Dimethylhydrazine in Rat Colon by Maslinic Acid, a Pentacyclic Triterpene from Olea europaea L.

The Potential for Plant-Based Diets to Promote Health Among Blacks Living in the United States

Interplay between Mediterranean Diet and Gut Microbiota in the Interface of Autoimmunity: An Overview

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