Great cervical venous tumoral thrombosis of melanotic medullary carcinoma thyroid: Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography enabled diagnosis and radiotherapy planning

Chigurupati, Mohana Vamsy; Madiraju, Vidya; Chigurupati, Namrata; Shinkar, Pawan Gulabrao; Dhagam, Snehalatha; Rao, Vatturi Venkata Satya Prabhakar

doi:10.4103/0972-3919.172361

Cited by 2 publications

(1 citation statement)

References 11 publications

(9 reference statements)

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“…MTC presents a wide variety of morphological phenotypes, such as follicular, papilliferous, small cell, giant cell, clear cell, oncocytic, squamous cell, and melanotic carcinomas [2–13]. Melanin-producing MTC was reported first by J. N. Marcus [2] and is an extremely rare clinically.…”

Section: Discussionmentioning

confidence: 99%

Pathological characteristics and genetic features of melanin-producing medullary thyroid carcinoma

Wang¹,

Yun²,

Wang³

et al. 2018

Diagn Pathol

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ObjectiveTo study the clinicopathological characteristics and genetic features of melanin-producing medullary thyroid carcinoma (MP-MTC).MethodsThe immunophenotype of MP-MTC was studied using the immunohistochemical method, and its genetic features were assayed using an amplification refractory mutation system or PCR method.ResultsA 71-year-old man presented with a slowly growing 5-cm mass on the left side of the neck for approximately two months. The cut surface of the neoplasm was brown and black. Melanin was found in the cytoplasm of tumor cells or the extracellular matrix. The tumor cells were positive for AE1/AE3, S-100 protein, melan A, HMB-45, synaptophysin, calcitonin, chromogranin A, melanoma, and thyroid transcription factor-1 (TTF-1) and negative for thyroglobulin. No typical genetic features were observed in this case. The patient showed no symptoms and recurrence at 12 months after the operation.ConclusionsThe tumor cells of MP-MTC were positive for melanin biomarkers, TTF-1 and exhibited no genetic features. Histopathology and immunohistochemistry of the tumor cells will aid accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Pathological characteristics and genetic features of melanin-producing medullary thyroid carcinoma

Wang¹,

Yun²,

Wang³

et al. 2018

Diagn Pathol

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Internal Jugular Vein Tumor Thrombus: A Tricky Question for the Thyroid Surgeon

et al. 2022

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Internal jugular vein tumor thrombus is an extremely rare condition in thyroid carcinoma, but it does exist. Correlated with greater aggressiveness with a higher incidence of distant metastases at diagnosis and a higher recurrence rate, this important prognostic element should be systematically investigated by ultrasound operators in all patients presenting with thyroid carcinoma. The patient’s follow-up must be careful. This can be a trap that surgeons must look for in their preoperative checklist. We report the case of a 58-year-old woman with an IJV thrombus associated with multiple bone metastases. She underwent successful surgical treatment, and postoperative pathology showed a poorly differentiated follicular carcinoma of the thyroid and a tumor thrombus in the internal jugular vein.

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Great cervical venous tumoral thrombosis of melanotic medullary carcinoma thyroid: Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography enabled diagnosis and radiotherapy planning

Cited by 2 publications

References 11 publications

Pathological characteristics and genetic features of melanin-producing medullary thyroid carcinoma

Pathological characteristics and genetic features of melanin-producing medullary thyroid carcinoma

Internal Jugular Vein Tumor Thrombus: A Tricky Question for the Thyroid Surgeon

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