Gray Scale Contrast Enhancement and Quantification in Different Positions of Rabbit Liver

Li, Jie; Dong, Baowei; Yu, Xiaoling; Li, Chuanfu

doi:10.7863/jum.2006.25.1.7

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…Here, we correlated the liver CEUS perfusion derived parenchyma and PV PSI and PIT with histology in CHC patients stratified according to their liver histological fibrosis score. In accordance with previously published data by Li et al (2006), our data showed that PV PSI was constantly higher than LP PSI values in all fibrosis stages. In our study, we found no correlation between PV PSI values and fibrosis scores.…”

Section: Discussionsupporting

confidence: 93%

Liver Contrast Enhanced Ultrasound Perfusion Imaging in the Evaluation of Chronic Hepatitis C Fibrosis: Preliminary Results

Orlacchio

Bolacchi

Petrella

et al. 2011

Ultrasound in Medicine & Biology

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Abstract-We wanted to determine whether liver contrast-enhanced ultrasound (CEUS)-derived peak signal intensity (PSI) and peak signal intensity/time (PIT) predict liver fibrosis in chronic hepatitis C (CHC). Fortynine patients with CHC (METAVIR classification) and 10 control subjects were included in the study. After a bolus of 2.4 mL SonoVue (Bracco Imaging, Milan, Italy) solution was injected into a peripheral vein, the right lobe of the liver containing the right portal vein was scanned in a transverse section. Two-dimensional sonography was performed using the Philips iU22 ultrasound system (Philips Healthcare, Best, the Netherlands). A 1.0-5.0-MHz (C5-1) wideband convex transducer was used, applying the following settings in all cases. Regions of interest were manually drawn over the right liver lobe and over the portal vein (PV). Liver parenchyma PSI (LPpsi) and PIT (LPpit), portal vein PSI (PVpsi) and PIT (PVpit) were automatically calculated. dPSI was defined as the difference between PVpsi and LPpsi. A significant correlation was observed between PA PSI and fibrosis scores. When patients were stratified according to their LPpsi, a significant difference was achieved only between patients with fibrosis score 0-1 vs. 2-3 and 2 vs. 4. Statistically significant differences between all fibrosis scores, except 0 vs. 1 and 3 vs. 4 were observed when dPSI was used to stratify patients. Overall diagnostic accuracy of LPpsi and dPSI measurement for severe fibrosis by area under the receiving operator characteristic curve analysis was, respectively, 0.87 and 0.88. We suggest that liver CEUS perfusion could have the potential to be used as a complementary tool for the evaluation of liver fibrosis. However, further large-scale studies are required to accurately assess its accuracy in the evaluation of liver fibrosis. (E-mail: aorlacchio@uniroma2.it) Ó 2011 World Federation for Ultrasound in Medicine & Biology.

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Section: Discussionsupporting

confidence: 93%

Liver Contrast Enhanced Ultrasound Perfusion Imaging in the Evaluation of Chronic Hepatitis C Fibrosis: Preliminary Results

Orlacchio

Bolacchi

Petrella

et al. 2011

Ultrasound in Medicine & Biology

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“…The PSI in the portal vein is higher than that in the liver parenchyma at every assessment stage, supporting Li J's results [11]. As the fibrosis developed, a progressive reduction of parenchyma PSI was observed in the late phase, which is accordance with Kaneko T's studies with Levovist [2], but did not occur with PV PSI, accordingly the gap between PV and parenchyma PSI is increased.…”

Section: Discussionsupporting

confidence: 82%

Grey scale enhancement by a new self-made contrast agent in early cirrhotic stage of rabbit liver

et al. 2007

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“…A weakness in the study was the small number of animals and injections used to calculate perfusion parameters. Results obtained from contrast‐enhanced ultrasound is influenced by machine‐, 17,19,23,24 contrast agent‐ 7,17,23,30 and patient‐related factors 7,17,19,23,31,32 . The injection protocol and technique was also partially responsible for the observed variation, because bubble concentration and size can vary from injection to injection, and from vial to vial, in a bolus study.…”

Section: Discussionmentioning

confidence: 99%

The Effect of the Sample Size and Location on Contrast Ultrasound Measurement of Perfusion Parameters

Leinonen

Raekallio

Vainio

et al. 2010

Vet Radiology Ultrasound

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Contrast-enhanced ultrasound can be used to quantify tissue perfusion based on region of interest (ROI) analysis. The effect of the location and size of the ROI on the obtained perfusion parameters has been described in phantom, ex vivo and in vivo studies. We assessed the effects of location and size of the ROI on perfusion parameters in the renal cortex of 10 healthy, anesthetized cats using Definity s contrast-enhanced ultrasound to estimate the importance of the ROI on quantification of tissue perfusion with contrast-enhanced ultrasound. Three separate sets of ROIs were placed in the renal cortex, varying in location, size or depth. There was a significant inverse association between increased depth or increased size of the ROI and peak intensity (Po0.05). There was no statistically significant difference in the peak intensity between the ROIs placed in a row in the near field cortex. There was no significant difference in the ROIs with regard to arrival time, time to peak intensity and wash-in rate. When comparing two different ROIs in a patient with focal lesions, such as suspected neoplasia or infarction, the ROIs should always be placed at same depth and be as similar in size as possible. r

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Gray Scale Contrast Enhancement and Quantification in Different Positions of Rabbit Liver

Abstract: Flow parameters are different between central and ventral peripheral positions and between left and right lobes of hepatic parenchyma.

Cited by 9 publications

References 22 publications

Liver Contrast Enhanced Ultrasound Perfusion Imaging in the Evaluation of Chronic Hepatitis C Fibrosis: Preliminary Results

Liver Contrast Enhanced Ultrasound Perfusion Imaging in the Evaluation of Chronic Hepatitis C Fibrosis: Preliminary Results

Grey scale enhancement by a new self-made contrast agent in early cirrhotic stage of rabbit liver

The Effect of the Sample Size and Location on Contrast Ultrasound Measurement of Perfusion Parameters

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