Gray Platelet Syndrome (GPS)

Shahraki, Hojat; Dorgalaleh, Akbar; Bain, Barbara J.

doi:10.1007/978-3-319-76723-9_16

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Platelet Activation End-points and Related Defects1

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2021

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“…Of note, content and surface expression of P-selectin are variable and their assessment is inadequate for diagnostic purposes [ 65 , 74 , 75 , 76 , 77 ]. The diagnosis is confirmed by the lack of α-granules observed by electron microscopy and by the absence of α-granule proteins [ 78 , 79 ].…”

Section: Platelet Activation End-points and Related Defectsmentioning

confidence: 99%

Thrombocytopathies: Not Just Aggregation Defects—The Clinical Relevance of Procoagulant Platelets

Aliotta

Calderara

Zermatten

et al. 2021

JCM

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Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in thrombocytopathies variously characterized by defects of their adhesive and procoagulant activation endpoints. In this review, we summarize the traditional platelet defects in adhesion, secretion, and aggregation. In addition, we review the current knowledge about procoagulant platelets, focusing on their role in bleeding or thrombotic pathologies and their pharmaceutical modulation. Procoagulant activity is an important feature of platelet activation, which should be specifically evaluated during the investigation of a suspected thrombocytopathy.

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