Gray matter volume of rostral anterior cingulate cortex predicts rapid antidepressant response to ketamine

Herrera-Meléndez, Ana Lucía; Stippl, Anna; Aust, Sabine; Scheidegger, Milan; Seifritz, Erich; Heuser-Collier, Isabella; Otte, Christian; Bajbouj, Malek; Grimm, Simone; Gärtner, Matti

doi:10.1016/j.euroneuro.2020.11.017

Cited by 22 publications

(2 citation statements)

References 54 publications

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“…Researchers have reported that rACC damage can alleviate pain aversion but does not affect mechanical hypersensitivity ( Shi et al, 2020 ). The rACC is involved in the rapid antidepressant effects of ketamine, and its gray matter volume is positively correlated with these effects ( Herrera-Melendez et al, 2021 ). Neurons located in the V-VI layer of the rACC are the main projection neurons ( Wu et al, 2009 ), which primarily consist of pyramidal neurons.…”

Section: Introductionmentioning

confidence: 99%

Rostral Anterior Cingulate Cortex–Ventrolateral Periaqueductal Gray Circuit Underlies Electroacupuncture to Alleviate Hyperalgesia but Not Anxiety-Like Behaviors in Mice With Spared Nerve Injury

Zhu

Shen

et al. 2022

Front. Neurosci.

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Neuropathic pain is a common cause of chronic pain and is often accompanied by negative emotions, making it complex and difficult to treat. However, the neural circuit mechanisms underlying these symptoms remain unclear. Herein, we present a novel pathway associated with comorbid chronic pain and anxiety. Using chemogenetic methods, we found that activation of glutamatergic projections from the rostral anterior cingulate cortex (rACCGlu) to the ventrolateral periaqueductal gray (vlPAG) induced both hyperalgesia and anxiety-like behaviors in sham mice. Inhibition of the rACCGlu-vlPAG pathway reduced anxiety-like behaviors and hyperalgesia in the spared nerve injury (SNI) mice model; moreover, electroacupuncture (EA) effectively alleviated these symptoms. Investigation of the related mechanisms revealed that the chemogenetic activation of the rACCGlu-vlPAG circuit effectively blocked the analgesic effect of EA in the SNI mice model but did not affect the chronic pain-induced negative emotions. This study revealed a novel pathway, the rACCGlu-vlPAG pathway, that mediates neuropathic pain and pain-induced anxiety.

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Section: Introductionmentioning

confidence: 99%

Rostral Anterior Cingulate Cortex–Ventrolateral Periaqueductal Gray Circuit Underlies Electroacupuncture to Alleviate Hyperalgesia but Not Anxiety-Like Behaviors in Mice With Spared Nerve Injury

Zhu

Shen

et al. 2022

Front. Neurosci.

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“…However, pronounced activity changes directly after administration have been less consistently reported for these regions, even though the pgACC supposedly plays a key role in mediating antidepressant effects [ 14 ], and has been discussed as a multimodal neuroimaging biomarker of early treatment response to ketamine [ 15 ]. We previously reported increased pgACC activity in response to negative emotional stimuli 24 h after ketamine administration in healthy participants [ 16 ] as well as an association of pretreatment pgACC volume and activity with rapid AD effects of ketamine in patients [ 15 , 17 ]. Depending on the investigated modality, rather inconsistent findings have also been reported for the dACC.…”

Section: Introductionmentioning

confidence: 99%

Negative emotionality shapes the modulatory effects of ketamine and lamotrigine in subregions of the anterior cingulate cortex

Gärtner,

Weigand,

Meiering

et al. 2024

Transl Psychiatry

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Neuroimaging studies have identified the anterior cingulate cortex (ACC) as one of the major targets of ketamine in the human brain, which may be related to ketamine’s antidepressant (AD) mechanisms of action. However, due to different methodological approaches, different investigated populations, and varying measurement timepoints, results are not consistent, and the functional significance of the observed brain changes remains a matter of open debate. Inhibition of glutamate release during acute ketamine administration by lamotrigine provides the opportunity to gain additional insight into the functional significance of ketamine-induced brain changes. Furthermore, the assessment of trait negative emotionality holds promise to link findings in healthy participants to potential AD mechanisms of ketamine. In this double-blind, placebo-controlled, randomized, single dose, parallel-group study, we collected resting-state fMRI data before, during, and 24 h after ketamine administration in a sample of 75 healthy male and female participants who were randomly allocated to one of three treatment conditions (ketamine, ketamine with lamotrigine pre- treatment, placebo). Spontaneous brain activity was extracted from two ventral and one dorsal subregions of the ACC. Our results showed activity decreases during the administration of ketamine in all three ACC subregions. However, only in the ventral subregions of the ACC this effect was attenuated by lamotrigine. 24 h after administration, ACC activity returned to baseline levels, but group differences were observed between the lamotrigine and the ketamine group. Trait negative emotionality was closely linked to activity changes in the subgenual ACC after ketamine administration. These results contribute to an understanding of the functional significance of ketamine effects in different subregions of the ACC by combining an approach to modulate glutamate release with the assessment of multiple timepoints and associations with trait negative emotionality in healthy participants.

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Ketamine and Other Glutamate Receptor Antagonists As Fast-Actin

Chen

Tsai

2022

Neuromethods

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Gray matter volume of rostral anterior cingulate cortex predicts rapid antidepressant response to ketamine

Cited by 22 publications

References 54 publications

Rostral Anterior Cingulate Cortex–Ventrolateral Periaqueductal Gray Circuit Underlies Electroacupuncture to Alleviate Hyperalgesia but Not Anxiety-Like Behaviors in Mice With Spared Nerve Injury

Rostral Anterior Cingulate Cortex–Ventrolateral Periaqueductal Gray Circuit Underlies Electroacupuncture to Alleviate Hyperalgesia but Not Anxiety-Like Behaviors in Mice With Spared Nerve Injury

Negative emotionality shapes the modulatory effects of ketamine and lamotrigine in subregions of the anterior cingulate cortex

Ketamine and Other Glutamate Receptor Antagonists As Fast-Actin

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