Gray Matter Volume Changes in the Apathetic Elderly

Yan, Hongjie; Onoda, Keiichi; Yamaguchi, Shûhei

doi:10.3389/fnhum.2015.00318

Cited by 10 publications

(14 citation statements)

References 62 publications

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“…These findings are consistent with the hypothesis that apathy results from disruption of the prefrontal–basal ganglia system,33 a previous study that showed a negative correlation between apathy severity and grey matter density in the bilateral insula in patients with PD,8 and another study that found putamen grey matter volume reductions in apathetic elderly subjects 34. Unlike a previous study that showed lower striatal DAT levels in apathetic patients with PD compared with non-apathetic patients,4 striatal DAT levels did not contribute to apathy in the current study.…”

Section: Discussionsupporting

confidence: 90%

Effects of dopaminergic depletion and brain atrophy on neuropsychiatric symptoms in de novo Parkinson’s disease

Jeon

Yoon

et al. 2017

J Neurol Neurosurg Psychiatry

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Section: Discussionsupporting

confidence: 90%

Effects of dopaminergic depletion and brain atrophy on neuropsychiatric symptoms in de novo Parkinson’s disease

Jeon

Yoon

et al. 2017

J Neurol Neurosurg Psychiatry

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“…; for example, the appearance of apathy has been related to a rapid progression to AD 66,67 Future neuroimaging analysis may help to better understand whether apathy affects all brain areas or is exclusively a frontal lobe pathology, as suggested by some studies. 5,32 In conclusion, this study provides new evidence demonstrating that symptoms of apathy affect mental resources differently, which concurs with Stuss et al, 2 Levy and Dubois 3 and Pagonabarraga et al 26 Assessment of apathy with the LARS in combination with an extensive neuropsychological battery allowed us to examine the influence of symptoms of apathy on cognitive performance. To our knowledge, this study is the first to determine that intellectual curiosity, emotion, action initiation and self-awareness factors are associated with a worse performance in attention, processing speed, verbal fluency, visual and verbal memory, working memory, and executive functioning in healthy elderly people.…”

Section: Discussionsupporting

confidence: 88%

The impact of apathy on cognitive performance in the elderly

Montoya-Murillo

Ibarretxe‐Bilbao

Peña

et al. 2019

Int J Geriat Psychiatry

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Objectives To examine the impact of apathy on cognitive performance in the elderly following the conceptual principles proposed by Marin 1 and Stuss et al 2 and to determine the role of the symptoms of apathy in different cognitive domains. Methods Cross‐sectional study with a cohort of healthy elderly subjects over 55 years old (n = 140). One hundred forty healthy‐elderly subjects (aged 79.24 ± 8.6 years old) were recruited from 12 day centers in Northern Spain. Participants underwent a neuropsychological battery, which evaluated Mini Mental State Examination (MMSE), attention, processing speed, verbal fluency, visual and verbal memory, working memory, and executive functioning. Apathy was assessed by the Lille Apathy Rating Scale (LARS), which is composed of four factors: intellectual curiosity, emotion, action initiation, and self‐awareness. Correlation and linear regression analyses were performed. Results In the correlational analysis, the LARS total score correlated negatively with global cognition, verbal fluency, and visual and verbal memory. The intellectual curiosity factor correlated negatively with all cognitive domains except attention. The emotion factor correlated negatively with visual memory. No correlation was found between the action initiation and self‐awareness factors or any of the cognitive variables. Multiple stepwise regression analysis showed that symptoms of apathy explained cognitive performance in attention, processing speed, verbal fluency, visual and verbal memory, working memory, executive functioning, and MMSE. Conclusions Apathy was significantly associated with cognitive performance, especially with the intellectual curiosity factor. Our results suggest that specific symptoms of apathy contribute differently to individual cognitive domains.

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“…And the MOG were also found to be increased in patients with EOD compare to young HC. The study on GMV of occipital gyrus increased in MDD patients were limited, but Yan et al found the GMV of left inferior occipital gyrus (IOG) were increased in aged healthy participants with apathy ( Yan et al, 2015 ). They speculated that the increased GMV of IOG might be compensations that enable effective behavior execution in aged participants.…”

Section: Discussionmentioning

confidence: 99%

Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset

Shen

Cheng

Yang

et al. 2016

NeuroImage: Clinical

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ObjectiveLittle is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also delineate EOD and LOD.MethodsIn present study, 147 first-episode, drug-naive patients with major depressive disorder (MDD), age between 18 and 45, were divided into two groups on the basis of age of MDD onset: the early adult onset group (age 18–29) and the later adult onset group (age 30–44), and a total of 130 gender-, and age-, matched healthy controls (HC) were also divided into two groups which fit for each patient group. Magnetic resonance imaging was conducted on all subjects. The voxel-based morphometry (VBM) approach was employed to analyze the images.ResultsWidespread abnormalities of GMV throughout parietal, temporal, limbic regions, occipital cortex and cerebellum were observed in MDD patients. Compare to young HC, reduced GMV in right fusiform gyrus, right middle temporal gyrus, vermis III and increased GMV in right middle occipital gyrus were seen in the EOD group. In contrast, relative to old HC, decreased GMV in the right hippocampus and increased GMV in the left middle temporal gyrus were observed in the LOD group. Compared to the LOD group, the EOD group had smaller GMV in right posterior cingulate cortex. There was no significant correlation between GMV of the right posterior cingulate cortex and the score of the depression rating scale in patients group.ConclusionsThe GMV of the brain areas that were related to mood regulation was decreased in the first-episode, drug-naive adult patients with MDD. Adult patients with EOD and LOD exhibited different GMV changes relative to each age-matched comparison group, suggesting depressed adult patients with different age-onset might have different pathological mechanism.

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Gray Matter Volume Changes in the Apathetic Elderly

Cited by 10 publications

References 62 publications

Effects of dopaminergic depletion and brain atrophy on neuropsychiatric symptoms in de novo Parkinson’s disease

Effects of dopaminergic depletion and brain atrophy on neuropsychiatric symptoms in de novo Parkinson’s disease

The impact of apathy on cognitive performance in the elderly

Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset

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