Gray Matter Decrease of the Anterior Cingulate Cortex in Anorexia Nervosa

Mühlau, Mark; Gaser, Christian; Ilg, Rüdiger; Conrad, Bastian; Leibl, Carl; Cebulla, Mario; Backmund, H.; Gerlinghoff, M.; Lommer, Peter; Schnebel, Andreas; Wohlschläger, Afra M.; Zimmer, Claus; Nunnemann, Sabine

doi:10.1176/appi.ajp.2007.06111861

Cited by 151 publications

(162 citation statements)

References 32 publications

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“…7,8 Moreover, although some of these alter ations may normalize in recovered patients, 4 other studies have shown the persistence of volume alterations in recovered patients. 7,9,10 The distributed nature of these changes implies disturbances of inter regional brain connectivity, as has been observed in most other psychiatric disorders. 11,12 At the same time, the major reorganization in white matter that the brain undergoes during adolescence and early adulthood is thought to be relevant to the development of some psychi atric disorders, including anorexia nervosa.…”

Section: Introductionmentioning

confidence: 90%

Disruption of brain white matter microstructure in women with anorexia nervosa

Via

Zalesky

Sánchez

et al. 2014

jpn

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Section: Introductionmentioning

confidence: 90%

Disruption of brain white matter microstructure in women with anorexia nervosa

Via

Zalesky

Sánchez

et al. 2014

jpn

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“…MRI has been used in human studies of the cognitive component of eating disorders such as anorexia nervosa (volumetric MRI, Muhlau et al 2007; fMRI, Vocks et al 2010) or nutritional disorders such as obesity (fMRI, Killgore & Yurgelun-Todd 2010).…”

Section: Feeding Behaviormentioning

confidence: 99%

MRI Techniques and New Animal Models for Imaging the Brain

Chaillou¹,

Tillet²,

Andersson³

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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“…Parietal and occipital cortical areas also appear to repeatedly distinguish AN from controls in states of hunger and satiety during cognitive processing of food pictures [21] . Some morphologic studies revealed differences for the AN patients in terms of grey matter decrease in the anterior cingulate cortex [22] .…”

Section: Influence Of Satiety and Subjective Valence Rating On Cerebrmentioning

confidence: 99%

Influence of Satiety and Subjective Valence Rating on Cerebral Activation Patterns in Response to Visual Stimulation with High-Calorie Stimuli among Restrictive Anorectic and Control Women

Gizewski¹,

Rosenberger

Greiff³

et al. 2010

Neuropsychobiology

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Background: There is evidence that patients with anorexia nervosa (AN) demonstrate specific cerebral activation patterns in response to visual food stimulation. We postulated that cerebral activation patterns could represent different perceptions of high-calorie images during hunger and satiety and could be determined by patients’ subjective ratings. Methods: After 6 h of starvation and also in a state of satiety, 12 female patients with AN and 12 normal-weight women were assessed by use of fMRI with high-calorie food images. All patients suffered from a restrictive type of AN. Heart rates, subjective ratings of satiety and valences of the visual stimuli were assessed. Results: Food stimuli presented during a state of hunger were associated with significant activation of the anterior cingulate cortex and insula in the control group and of the prefrontal and central cortices and insula in the AN group. During the hunger state activation in AN of the dorsal posterior cingulate cortex was revealed compared to the controls. In the state of satiety, activation of the left insula was observed in the AN group. Use of the food valence judgment as a covariate confirmed the insula activation and revealed additional activation of the orbitofrontal, cingulate and medial temporal cortices. Conclusion: Our results indicate differences in cerebral activation patterns due to different perceptions of high-calorie food images, modulated by feelings of hunger or satiety, among AN patients with modulation by subjective ratings of food valence.

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Gray Matter Decrease of the Anterior Cingulate Cortex in Anorexia Nervosa

Cited by 151 publications

References 32 publications

Disruption of brain white matter microstructure in women with anorexia nervosa

Disruption of brain white matter microstructure in women with anorexia nervosa

MRI Techniques and New Animal Models for Imaging the Brain

Influence of Satiety and Subjective Valence Rating on Cerebral Activation Patterns in Response to Visual Stimulation with High-Calorie Stimuli among Restrictive Anorectic and Control Women

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