Gray Matter Atrophy: The Impacts of Resective Surgery and Vagus Nerve Stimulation in Drug-Resistant Epilepsy

Lam, Jørgen; Cabeen, Ryan P.; Tanna, Runi; Navarro, Lauren; Heck, Christianne; Liu, Charles Y.; Lee, Brian; Russin, Jonathan; Toga, Arthur W.; Lee, Darrin J.

doi:10.1016/j.wneu.2021.01.141

Cited by 3 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, our findings revealed a significant reduction (i.e., thinning) in the cortical thickness in the ipsilateral lateral orbitofrontal cortex in the left TLE patients compared to the control group. This finding was also in agreement with the findings of other studies [ 48 , 53 ]. The bilateral cortex thinning of rostral anterior cingulate region was observed in this study which was in agreement with previous studies [ 54 ].…”

Section: Discussionsupporting

confidence: 94%

Cortical thickness analysis in temporal lobe epilepsy using fully Bayesian spectral method in magnetic resonance imaging

et al. 2022

View full text Add to dashboard Cite

Background Temporal lobe epilepsy (TLE) is the most common type of epilepsy associated with changes in the cerebral cortex throughout the brain. Magnetic resonance imaging (MRI) is widely used for detecting such anomalies; nevertheless, it produces spatially correlated data that cannot be considered by the usual statistical models. This study aimed to compare cortical thicknesses between patients with TLE and healthy controls by considering the spatial dependencies across different regions of the cerebral cortex in MRI. Methods In this study, T1-weighted MRI was performed on 20 healthy controls and 33 TLE patients. Nineteen patients had a left TLE and 14 had a right TLE. Cortical thickness was measured for all individuals in 68 regions of the cerebral cortex based on images. Fully Bayesian spectral method was utilized to compare the cortical thickness of different brain regions between groups. Neural networks model was used to classify the patients using the identified regions. Results For the left TLE patients, cortical thinning was observed in bilateral caudal anterior cingulate, lateral orbitofrontal (ipsilateral), the bilateral rostral anterior cingulate, frontal pole and temporal pole (ipsilateral), caudal middle frontal and rostral middle frontal (contralateral side). For the right TLE patients, cortical thinning was only observed in the entorhinal area (ipsilateral). The AUCs of the neural networks for classification of left and right TLE patients versus healthy controls were 0.939 and 1.000, respectively. Conclusion Alteration of cortical gray matter thickness was evidenced as common effect of epileptogenicity, as manifested by the patients in this study using the fully Bayesian spectral method by taking into account the complex structure of the data.

show abstract

Section: Discussionsupporting

confidence: 94%

Cortical thickness analysis in temporal lobe epilepsy using fully Bayesian spectral method in magnetic resonance imaging

et al. 2022

View full text Add to dashboard Cite

show abstract

“…( Frangos et al, 2015 , Zhu et al, 2021 ) Vagal activation of these various brain regions has been shown to be associated with changes in gray matter volume that correlate with treatment response in studies of epilepsy and depression. ( Zhu et al, 2021 , Grayston et al, 2019 , Perini et al, 2017 , Lam et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Percutaneous electric nerve field stimulation alters cortical thickness in a pilot study of veterans with fibromyalgia

Woodbury

Krishnamurthy

Bohsali

et al. 2022

Neurobiology of Pain

View full text Add to dashboard Cite

“…Vagal afferents result in increased parasympathetic activation, improving mood and sleep, and decreasing stress and inflammation through activation of the cholinergic anti-inflammatory pathway (2). Historically, vagus nerve stimulation has been delivered through a surgically-implanted pacemaker-like device and utilized for a range of neurological conditions including refractory epilepsy and depression (3)(4)(5). Surgical implantation, however, is associated with a risk of infection, bleeding, and nerve damage and the inherent cost of an implanted device.…”

Section: Introductionmentioning

confidence: 99%

Editorial: Non-invasive and minimally invasive vagus nerve stimulation for chronic pain

Woodbury,

Staats

2024

Front. Pain Res.

View full text Add to dashboard Cite

show abstract

Gray Matter Atrophy: The Impacts of Resective Surgery and Vagus Nerve Stimulation in Drug-Resistant Epilepsy

Cited by 3 publications

References 44 publications

Cortical thickness analysis in temporal lobe epilepsy using fully Bayesian spectral method in magnetic resonance imaging

Cortical thickness analysis in temporal lobe epilepsy using fully Bayesian spectral method in magnetic resonance imaging

Percutaneous electric nerve field stimulation alters cortical thickness in a pilot study of veterans with fibromyalgia

Editorial: Non-invasive and minimally invasive vagus nerve stimulation for chronic pain

Contact Info

Product

Resources

About