Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

Rotgé, Jean-Yves; Langbour, Nicolas; Guehl, Dominique; Bioulac, Bernard; Jaafari, Nématollah; Allard, Michèle; Aouizerate, Bruno; Burbaud, Pierre

doi:10.1038/npp.2009.175

Cited by 202 publications

(178 citation statements)

References 34 publications

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“…Previous studies have reported GM reduction in OCD in several regions and commonly in the frontal areas, 9,22 which were consistent with our result. On the other hand, we did not find altered volume in the basal ganglia or anterior cingulate, which has often been reported.…”

Section: Discussionsupporting

confidence: 83%

“…A meta-analysis reported that patients with OCD showed reduced GM in the parietofrontal cortical regions, including the supramarginal gyrus, dorsolateral prefrontal cortex (DLPFC), and orbitofrontal cortex, and increased GM in the putamen and anterior prefrontal cortex. 9 In contrast, VBM meta-analyses of ASD have brought controversial results. In ASD, NicklJockschat and associates reported disturbances in several regions, including the lateral occipital lobe, pericentral region, medial temporal lobe, and basal ganglia and proximate to the right parietal operculum, 10 and Via and associates found robust decreases in GM volume in the bilateral amygdala-hippocampus complex and the bilateral precuneus as well as a small increase in the middle-inferior frontal gyrus.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Morphologic Changes and Autism Spectrum Tendency in Obsessive-Compulsive Disorder

et al. 2015

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Objectives: Obsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric disorders, with some speculating that a reason for difficulty in its treatment might be its coexistence with autism spectrum. We investigated the tendency for autistic spectrum disorders (ASD) in patients with OCD from a neuroimaging point of view using voxel-based morphometry.Methods: We acquired T 1 -weighted images from 20 patients with OCD and 30 healthy controls and investigated the difference in regional volume between the groups as well as the correlation between Autism-Spectrum Quotient (AQ) scores and regional cerebral volumes of patients with OCD.Results: Volumes in the bilateral middle frontal gyri were significantly decreased in patients with OCD compared to controls. Correlational analysis showed significant positive correlations between AQ scores and regional gray matter (GM) volumes in the left dorsolateral prefrontal cortex (DLPFC) and left amygdala. Furthermore, GM volumes of these regions were positively correlated with each other.Conclusions: The positive correlation of ASD traits in patients with OCD with regional GM volumes in the left DLPFC and amygdala could reflect the heterogeneity of patient symptoms. Our results suggest that differences in GM volume might allow classification of patients with OCD for appropriate therapy based on their particular traits.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Correlation between Morphologic Changes and Autism Spectrum Tendency in Obsessive-Compulsive Disorder

et al. 2015

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“…[2][3][4] A recent review article 5 confirmed these results and concluded that structural alterations in patients with OCD are widespread and occur most probably at a network level, with cortical tissue reductions and a tendency toward increases in grey matter volume of subcortical limbic areas. These subcortical tissue increases were also corroborated by a recent meta/mega-analysis of the ENIGMA OCD imaging consortium.…”

Section: Introductionmentioning

confidence: 56%

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Rus

Reeß

Wagner

et al. 2017

JPN

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IntroductionStudying the brain anatomic structure offers a promising approach to improve our understanding of neural functional alter ations often encountered in individuals with psychiatric disorders. In those with obsessive-compulsive disorder (OCD), a psychiatric disorder with a 2%-3% lifetime prevalence 1 that causes strong impairment of daily life, findings up to now show disruptions on a functional and a structural neural level, mainly in a network including cortico-striatothalamo-cortical (CSTC) areas. Overall, these findings are rather inconsistent and limited by confounding factors, such as differences in clinical characteristics of the study sample or varying methodological approaches.Meta-analytic reviews showed that cortical areas, mainly the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC) and parietofrontal regions, seem to be predominantly affected by grey matter volume deficits in patients with OCD, whereas the lenticular nuclei and thalamus were found to be characterized by increases in grey matter volume.2-4 A recent review article 5 confirmed these results and concluded that structural alterations in patients with OCD are widespread and occur most probably at a network level, with cortical tissue reductions and a tendency toward increases in grey matter volume of subcortical limbic areas. These subcortical tissue increases were also corroborated by a recent meta/mega-analysis of the ENIGMA OCD imaging consortium. 6 Additionally, this meta/mega-analysis showed that the neuroplasticity of specific areas depends on the age of the studied sample (i.e., smaller hippocampal but larger pallidum volumes were prominent in adults with OCD, whereas only larger thalamic volumes were specific for pediatric patients). Besides grey matter volume alterations in patients with OCD, significantly decreased grey matter thickness in partly overlapping areas (i.e., limbic, parietal and temporal areas) was also found in another recent mega-analysis. 7 It is Background: Mounting evidence indicates the presence of structural brain alterations in individuals with obsessive-compulsive disorder (OCD). Findings are, however, rather heterogeneous, which may be partly because of differences in methodological approaches or clinical sample characteristics. The aim of the present study was to analyze the whole brain cortical volume, surface area and thickness in a large sample of patients with OCD compared with age-and sex-matched healthy controls. Methods: We conducted whole brain surfacebased analyses of grey matter measures using the automated FreeSurfer software in patients with OCD and matched controls. Group analyses were performed and corrected for multiple testing using Monte Carlo simulations (p < 0.05). Altered brain regions and their average morphological values were associated to symptom severity and type (Yale-Brown Obsessive Compulsive Scale scores). Results:We included 75 patients and 75 controls in our analyses. Patients with OCD showed decreases in both volume and surface area compared with healthy ...

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“…However, the involvement of the serotonergic [4][5][6][7] , dopaminergic 8,9 and glutamatergic 10 systems has been demonstrated in this disorder. In addition, the orbitofrontal cortex, the cingulate cortex, the basal ganglia and regions within the parietal lobe have been implicated in its pathophysiology 7,[11][12][13] . Finally, life events related to fluctuations in the level of ovarian hormones (e.g., child birth, ovulation) have been reported to trigger or exacerbate OCD in women patients [14][15][16] , suggesting that ovarian hormones play a modulatory role in OCD 17 .…”

Section: Introductionmentioning

confidence: 99%

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Goltseker

Yankelevitch-Yahav

Albelda

et al. 2015

JoVE

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In the signal attenuation rat model of obsessive-compulsive disorder (OCD), lever-pressing for food is followed by the presentation of a compound stimulus which serves as a feedback cue. This feedback is later attenuated by repeated presentations of the stimulus without food (without the rat emitting the lever-press response). In the next stage, lever-pressing is assessed under extinction conditions (i.e., no food is delivered). At this stage rats display two types of lever-presses, those that are followed by an attempt to collect a reward, and those that are not. The latter are the measure of compulsive-like behavior in the model. A control procedure in which rats do not experience the attenuation of the feedback cue serves to distinguish between the effects of signal attenuation and of extinction. The signal attenuation model is a highly validated model of OCD and differentiates between compulsive-like behaviors and behaviors that are repetitive but not compulsive. In addition the measures collected during the procedure eliminate alternative explanations for differences between the groups being tested, and are quantitative, unbiased and unaffected by inter-experimenter variability. The major disadvantages of this model are the costly equipment, the fact that it requires some technical know-how and the fact that it is time-consuming compared to other models of OCD (11 days). The model may be used for detecting the anti-or pro-compulsive effects of pharmacological and non-pharmacological manipulations and for studying the neural substrate of compulsive behavior.

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Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

Cited by 202 publications

References 34 publications

Correlation between Morphologic Changes and Autism Spectrum Tendency in Obsessive-Compulsive Disorder

Correlation between Morphologic Changes and Autism Spectrum Tendency in Obsessive-Compulsive Disorder

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

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