Gray and white matter asymmetries in healthy individuals aged 21–29 years: A voxel‐based morphometry and diffusion tensor imaging study

Takao, Hidemasa; Abe, Osamu; Yamasue, Hidenori; Aoki, Shigeki; Sasaki, Hiroki; Kasai, Kiyoto; Yoshioka, Naoki; Ohtomo, Kuni

doi:10.1002/hbm.21145

Cited by 103 publications

(108 citation statements)

References 62 publications

(103 reference statements)

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“…Our results indicate a lack of sexual dimorphism with respect to gray matter asymmetry in BA 44/45 and as such are in line with prior findings that do not support a sex difference in region-specific asymmetry (Good et al 2001a; Luders et al 2004; Savic 2014; Takao et al 2011; Watkins et al 2001). Furthermore, they seem to agree with conclusions drawn based on a meta-analysis (Frost et al 1999; Sommer et al 2004) negating that women are having more bilateral language representation (and thus presumably less asymmetry) than men, as also critically reviewed elsewhere (Wallentin 2009).…”

Section: Discussionsupporting

confidence: 93%

Sexual dimorphism of Broca's region: More gray matter in female brains in Brodmann areas 44 and 45

Kurth

Jäncke

Lüders

2016

J of Neuroscience Research

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While a sexual dimorphism in brain structure is generally well established, evidence for sex differences in Brodmann Areas (BA) 44 and 45 is inconclusive. This may be due to the difficulty of accurately defining BA 44 and BA 45 in magnetic resonance images, given that these regions are variable in their location and extent and that they do not match well with macro-anatomic landmarks. Here, we set out to test for possible sex differences in the local gray matter of BA 44/45 by integrating imaging-based signal intensities with cytoarchitectonically defined tissue probabilities in a sample of 50 male and 50 female subjects. In addition to testing for sex differences with respect to left- and right-hemispheric measures of BA 44/45, we also assessed possible sex differences in BA 44/45 asymmetry. Our analyses revealed significantly larger gray matter volumes in females compared to males for BA 44 and BA 45 bilaterally. However, there was a lack of significant sex differences in BA 44/45 asymmetry. These results corroborate reports of a language-related female superiority, particularly with respect to verbal fluency and verbal memory tasks.

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Section: Discussionsupporting

confidence: 93%

Sexual dimorphism of Broca's region: More gray matter in female brains in Brodmann areas 44 and 45

Kurth

Jäncke

Lüders

2016

J of Neuroscience Research

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“…Laterality in the optic radiation was also reported in children, youth, and adults; however, the direction varied in different parts of the optic radiation (Kang et al, 2011; Park et al, 2004; Takao et al, 2011; Thiebaut de Schotten et al, 2011; Xie et al, 2007). Our findings are consistent with a prior study of children and youth that found left lateralization of FA values due to a higher first eigenvalue, suggesting a lower axon density in the left hemisphere (Dayan et al, 2015).…”

Section: Discussionmentioning

confidence: 89%

Probabilistic maps of the white matter tracts with known associated functions on the neonatal brain atlas: Application to evaluate longitudinal developmental trajectories in term-born and preterm-born infants

et al. 2016

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Diffusion tensor imaging (DTI) has been widely used to investigate the development of the neonatal and infant brain, and deviations related to various diseases or medical conditions like preterm birth. In this study, we created a probabilistic map of fiber pathways with known associated functions, on a published neonatal multimodal atlas. The pathways-of-interest include the superficial white matter (SWM) fibers just beneath the specific cytoarchitectonically defined cortical areas, which were difficult to evaluate with existing DTI analysis methods. The Jülich cytoarchitectonic atlas was applied to define cortical areas related to specific brain functions, and the Dynamic Programming (DP) method was applied to delineate the white matter pathways traversing through the SWM. Probabilistic maps were created for pathways related to motor, somatosensory, auditory, visual, and limbic functions, as well as major white matter tracts, such as the corpus callosum, the inferior fronto-occipital fasciculus, and the middle cerebellar peduncle, by delineating these structures in eleven healthy term-born neonates. In order to characterize maturation-related changes in diffusivity measures of these pathways, the probabilistic maps were then applied to DTIs of 49 healthy infants who were longitudinally scanned at three time-points, approximately five weeks apart. First, we investigated the normal developmental pattern based on 19 term-born infants. Next, we analyzed 30 preterm-born infants to identify developmental patterns related to preterm birth. Last, we investigated the difference in diffusion measures between these groups to evaluate the effects of preterm birth on the development of these functional pathways. Term-born and preterm-born infants both demonstrated a time-dependent decrease in diffusivity, indicating postnatal maturation in these pathways, with laterality seen in the corticospinal tract and the optic radiation. The comparison between term- and preterm-born infants indicated higher diffusivity in the preterm-born infants than in the term-born infants in three of these pathways: the body of the corpus callosum; the left inferior longitudinal fasciculus; and the pathway connecting the left primary/ secondary visual cortices and the motion-sensitive area in the occipitotemporal visual cortex (V5/MT+). Probabilistic maps provided an opportunity to investigate developmental changes of each white matter pathway. Whether alterations in white matter pathways can predict functional outcomes will be further investigated in a follow-up study.

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“…Mean FA, mean ADC, number of streamlines (tract‐count) (e.g., Catani & Thiebaut de Schotten, 2008; Thiebaut de Schotten et al., 2011), mean streamline length (tract‐length) (e.g., Baker et al., 2016; Cohen et al., 2016), and total volume of all streamlines within a tract (tract‐volume) (e.g., Büchel et al., 2004; Eluvathingal, Hasan, Kramer, Fletcher, & Ewing‐Cobbs, 2007; Kulikova et al., 2014; Liu et al., 2010; Takao et al., 2011) corresponding to each cerebellar peduncle pathway (SCP, MCP cog , MCP mot , and ICP) were quantified in each subject. Left and right hemispheric values for each quantity (tract‐count, tract‐volume, mean tract‐length, mean FA, and mean ADC) in each pathway (SCP, MCP cog , MCP mot , and ICP) were compared to check for asymmetry using the Laterality Index (LI) where LI = (ValueOnLeft – ValueOnRight)/(ValueOnLeft + ValueOnRight).…”

Section: Methodsmentioning

confidence: 99%

High‐angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults

Levman

Lim

et al. 2016

Brain and Behavior

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IntroductionMany neurologic and psychiatric disorders are thought to be due to, or result in, developmental errors in neuronal cerebellar connectivity. In this connectivity analysis, we studied the developmental time‐course of cerebellar peduncle pathways in pediatric and young adult subjects.MethodsA cohort of 80 subjects, newborns to young adults, was studied on a 3T MR system with 30 diffusion‐weighted measurements with high‐angular resolution diffusion imaging (HARDI) tractography.ResultsQualitative and quantitative results were analyzed for age‐based variation. In subjects of all ages, the superior cerebellar peduncle pathway (SCP) and two distinct subpathways of the middle cerebellar peduncle (MCP), as described in previous ex vivo studies, were identified in vivo with this technique: pathways between the rostral pons and inferior‐lateral cerebellum (MCP cog), associated predominantly with higher cognitive function, and pathways between the caudal pons and superior‐medial cerebellum (MCP mot), associated predominantly with motor function.DiscussionOur findings showed that the inferior cerebellar peduncle pathway (ICP), involved primarily in proprioception and balance appears to have a later onset followed by more rapid development than that exhibited in other tracts. We hope that this study may provide an initial point of reference for future studies of normal and pathologic development of cerebellar connectivity.

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Gray and white matter asymmetries in healthy individuals aged 21–29 years: A voxel‐based morphometry and diffusion tensor imaging study

Cited by 103 publications

References 62 publications

Sexual dimorphism of Broca's region: More gray matter in female brains in Brodmann areas 44 and 45

Sexual dimorphism of Broca's region: More gray matter in female brains in Brodmann areas 44 and 45

Probabilistic maps of the white matter tracts with known associated functions on the neonatal brain atlas: Application to evaluate longitudinal developmental trajectories in term-born and preterm-born infants

High‐angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults

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