Gravity leukapheresis—A simple method of leukocyte collection for transfusion or in vitro study

Aisner, Joseph; Schiffer, Charles A.; Hedmann, Shaun; Wiernik, Peter H.

doi:10.1016/0145-2126(79)90002-x

Leukemia Research

1979

DOI: 10.1016/0145-2126(79)90002-x

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Gravity leukapheresis—A simple method of leukocyte collection for transfusion or in vitro study

Joseph Aisner

Charles A. Schiffer

Shaun Hedmann

et al.

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Cited by 13 publications

(1 citation statement)

References 24 publications

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“…RBC-sedimenting activity and the forma tion of rouleaux by dextran are quantitative ly correlated with molecular weight [MW; 4], Dextrans of MW < 60,000 actually prointroduction Erythrocyte (RBC)-sedimenting agents, hydroxyethyl starch (HES) and dextran, are employed electively during continuous-flow centrifugation leukapheresis to improve neu trophil yields [5], Their use is mandatory to insure adequate neutrophil collection by gravity leukapheresis [1] and intermittentflow centrifugation techniques [2]. Although HES and dextran are used liberally for these purposes in the USA and abroad, respective ly, concern for donors has arisen because of potential risks such as bleeding, hyper sensitivity reactions and prolonged intravas cular persistence of colloid [3,6], A low-mote RBC dispersion [4].…”

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confidence: 99%

In vitro Comparison of the Erythrocyte Sedimenting Properties of Dextran, Hydroxyethyl Starch and a New Low-Molecular-Weight Hydroxyethyl Starch

Strauss¹

1979

Vox Sanguinis

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A low-molecular-weight preparation of hydroxyethyl starch (LMW-HES) may serve as a desirable substitute for the erythrocyte sedimenting agents presently employed to improve neutrophil yields in centrifugation and gravity leukapheresis. The cell-separating and erythrocyte-sedimenting properties of LMW-HES, assessed in vitro by the recovery of various blood cells in plasma supernatant fluids, were similar to those of the higher-molecular-weight hydroxyethyl starch in current use and to dextran under a variety of conditions. These data predict success for LMW-HES as a sedimenting agent in leukapheresis and recommend that it be evaluated in clinical trials.

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confidence: 99%

In vitro Comparison of the Erythrocyte Sedimenting Properties of Dextran, Hydroxyethyl Starch and a New Low-Molecular-Weight Hydroxyethyl Starch

Strauss¹

1979

Vox Sanguinis

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Granulocyte transfusion therapy and amphotericin B: Adverse reactions?

et al. 1989

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One hundred twenty-five granulocyte transfusions were given concurrently with amphotericin B to 31 granulocytopenic patients with acute leukemia during a four year period. Twenty-six patients had culture-documented, and 5 had presumed fungal infections; pulmonary infiltrates were present in 26 patient courses. Eight patients developed pulmonary deterioration temporally related to therapy with amphotericin, granulocyte transfusions, or both. One event occurred following amphotericin alone. Three additional reactions occurred in alloimmunized patients with antibodies to human leukocyte antigens (HLA) who received random donor granulocytes, which may indicate a potential mechanism for the pulmonary reactions. Two reactions potentially represent an adverse interaction between amphotericin and granulocytes, but these were reversible and were not unlike reactions expected with each modality alone. Our data fail to document a specific detrimental interaction between granulocyte transfusions and amphotericin beyond the reactions associated with each modality, and the data suggest that other clinical factors, particularly infection and alloimmunization, also contribute to pulmonary decompensation. We nevertheless recommend great care and attention be given to administering these modalities in the setting of severely ill patients.

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Granulocyte transfusions in neutropenic patients

Menitove

Abrams

1987

Critical Reviews in Oncology/Hematology

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Gravity leukapheresis—A simple method of leukocyte collection for transfusion or in vitro study

Cited by 13 publications

References 24 publications

In vitro Comparison of the Erythrocyte Sedimenting Properties of Dextran, Hydroxyethyl Starch and a New Low-Molecular-Weight Hydroxyethyl Starch

In vitro Comparison of the Erythrocyte Sedimenting Properties of Dextran, Hydroxyethyl Starch and a New Low-Molecular-Weight Hydroxyethyl Starch

Granulocyte transfusion therapy and amphotericin B: Adverse reactions?

Granulocyte transfusions in neutropenic patients

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