Graves’ disease in a 3 year-old patient with agranulocytosis due to anti-thyroid drugs: Radioiodine ablation therapy as an effective alternative

Espinosa-Muñoz, E.; Ramírez-Ocaña, D.; Martín-García, Ana; Ruiz-García, F.; Puentes-Zarzuela, C.

doi:10.1016/j.remnie.2017.01.006

Cited by 4 publications

(10 citation statements)

References 5 publications

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“…Thyroid hormones play an important role in the development of the central nervous system and growth. A situation of thyroid hyperfunction can interfere with growth and development, result in growth retardation, brain damage due to craniosynostosis and cognitive impairment [8].…”

Section: Fine and Brittle Hair Or A Diffuse Hair Loss Due To An Accelmentioning

confidence: 99%

“…In the case of diffuse goiter due to Graves' disease, thyroid scintigraphy shows a diffuse enlargement of thyroid with a homogeneous distribution of the radiotracer and markedly increased uptake of both thyroid glands suggestive of hyperfunction [8]. Activity throughout the gland is increased relative to the background due to both increased stimulation and function of the gland (Figure 1).…”

Section: Evaluation Of Thyrotoxicosis Associated With Thyroid Hyperfumentioning

confidence: 99%

“…Current therapeutic options for these pathologies include antithyroid drugs (ATD), radioactive iodine and thyroidectomy. The choice of treatment depends on the type of pathology (Graves' disease, toxic multinodular goiter, pretoxic or toxic adenoma), physiological characteristics of the patient (age, pregnancy, breastfeeding), co-morbidities (advanced age, heart failure, large compressive intrathoracic goiters, thyroid ophthalmopathy), as well as refractoriness to the treatment administered [8,14].…”

Section: Different Therapeutic Options In Hyperthyroidismmentioning

confidence: 99%

“…Antithyroid drugs (ATD) therapy is usually recommended as the initial treatment for hyperthyroidism (especially in Graves' disease), achieving normalization of thyroid function in 4-6 weeks [8].…”

Section: Different Therapeutic Options In Hyperthyroidismmentioning

confidence: 99%

“…The medication is prescribed for 12-18 months normally, with the aim of achieving remission of the disease. However, the frequency of recurrences (more frequently in young males) and severe side effects like cytopenias, vasculitis, liver failure or agranulocytosis (higher in pediatric patients than adults) are a main limitation of ATD treatment [8,14,16].…”

Section: Different Therapeutic Options In Hyperthyroidismmentioning

confidence: 99%

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Nuclear Medicine in the Assessment of Thyrotoxicosis Associated with Increased Thyroid Function and Radioiodine 131 Ablative Therapies

Muñoz¹

2019

Thyroid Disorders

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Nuclear medicine is directly involved in both the diagnosis and treatment of benign thyroid disease. Thyroid scintigraphy (most commonly with technetium-99 m pertechnetate) should be used as the imaging modality of choice for assessment of thyrotoxicosis, since it demonstrates the functional state of the thyroid gland. An adequate understanding of the pathophysiological mechanisms and characteristics of the patient is essential, as well as the different treatments of thyroid disorders that present with hyperthyroidism (Graves' disease, toxic multinodular goiter, and toxic adenoma-Plummer's disease). Therapeutic modalities include antithyroid drugs, radioiodine and surgery. Antithyroid drugs are the first line of therapy and regarding the use of radioiodine, current recommendations consider it a safe and effective therapeutic alternative in hyperthyroidism. Finally, we highlight the existence of some special situations (children, pregnancy, thyroid eye disease, chronic renal failure and dialysis patients) and the importance of radiation protection measures to the patient, the public and professionals.

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Section: Fine and Brittle Hair Or A Diffuse Hair Loss Due To An Accelmentioning

confidence: 99%

Section: Evaluation Of Thyrotoxicosis Associated With Thyroid Hyperfumentioning

confidence: 99%

Section: Different Therapeutic Options In Hyperthyroidismmentioning

confidence: 99%

Section: Different Therapeutic Options In Hyperthyroidismmentioning

confidence: 99%

Section: Different Therapeutic Options In Hyperthyroidismmentioning

confidence: 99%

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Nuclear Medicine in the Assessment of Thyrotoxicosis Associated with Increased Thyroid Function and Radioiodine 131 Ablative Therapies

Muñoz¹

2019

Thyroid Disorders

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Carbimazole

2017

Reactions Weekly

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Endocrine features of primary mitochondrial diseases

Romo,

Gold,

Walker

2023

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review Primary mitochondrial diseases are one of the most prevalent groups of multisystem genetic disorders. Endocrinopathies associated with mitochondrial diseases may have clinical features that are distinct from the more common forms. We provide an overview of mitochondrial disorder genetics and phenotypes, focusing on recent studies regarding identification and treatment of associated endocrinopathies. Recent findings Known endocrine phenotypes of mitochondrial disorders continue to expand, and now include growth hormone deficiency, hypogonadism, precocious puberty, hypoparathyroidism, hypo- and hyperthyroidism, diabetes, and adrenal insufficiency. Recent studies suggest several genotype-phenotype correlations, including those related to nuclear variants. Diagnosis is important, as special considerations should be made in the management of endocrinopathies in mitochondrial patients. Finally, new mitochondrial replacement strategies may soon be available for women interested in preventing mitochondrial disease transmission to offspring. Summary Patients with multiple endocrinopathies or atypical endocrinopathies should be evaluated for primary mitochondrial disease, as a diagnosis may impact management of these individuals.

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Graves’ disease in a 3 year-old patient with agranulocytosis due to anti-thyroid drugs: Radioiodine ablation therapy as an effective alternative

Cited by 4 publications

References 5 publications

Nuclear Medicine in the Assessment of Thyrotoxicosis Associated with Increased Thyroid Function and Radioiodine 131 Ablative Therapies

Nuclear Medicine in the Assessment of Thyrotoxicosis Associated with Increased Thyroid Function and Radioiodine 131 Ablative Therapies

Carbimazole

Endocrine features of primary mitochondrial diseases

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