Abstract:Epigenetic changes at specific genetic loci and the activation of transcriptional repressor FOXP3 are needed to establish and maintain the regulatory T cell (Treg) lineage. Here we studied the DNA methylation profiles in CD4+ CD25+ Tregs and CD4+ CD25- conventional T cells (Tconvs) from healthy individuals and identified a wide range of differentially methylated CpG sites (DMPs). Overall, Tregs had more hypomethylated DMPs and contained more CpG sites, which on the cell population level were less defined in th… Show more
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