Grass pollen allergens: new developments

Wissenbach,; Holm,; Neerven, R. J. Joost van; Ipsen,

doi:10.1046/j.1365-2222.1998.00296.x

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…Grass pollens are the most important pollen allergen group in many European countries and in our country 3,19 . Cross-reactions are observed between many grass pollen types 8,20 . Tree pollens show regional variation but pollenization is generally between the months of Febru-ary and April.…”

Section: Discussionmentioning

confidence: 99%

Skin prick test results of child patients diagnosed as bronchial asthma

Mısırlıoğlu

Cengizlier

2007

Allergologia et Immunopathologia

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Background:The pathogenesis of asthma is associated with both genetic and environmental factors. Allergen sensitization is an important risk factor in asthma development. Aim: To evaluate sensitivity to allergens by using the skin prick test in patients with a diagnosis of bronchial asthma. Method: Patients with a diagnosis of bronchial asthma followed-up at the Ministry of Health, Diskapi Children's Diseases Training and Research Hospital in Ankara (Turkey) between January 1995 and March 2000 were included. Sensitivity to allergens, as determined by the skin prick test, was evaluated retrospectively. Results: The files of a total of 3025 children (63.3 % boys) with bronchial asthma, aged 3 months to 16 years were evaluated. Of the total, 1667 patients with a diagnosis of bronchial asthma and 1358 with bronchial asthma plus allergic rhinitis were under follow-up. Of the 3025 asthmatic patients, 1902 had undergone the skin prick test and 60.3 % of these patients were atopic. The most common allergens were house dust mite [726 patients (63.3 %)], followed by pollens [565 patients (49.3 %)]. The most common allergen within this group was grass pollens [348 patients (30.3 %)]. Conclusions: Atopy was an important risk factor in our patients and the most common allergens were aeroallegens. The development of sensitization could be delayed by early precautions.

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Section: Discussionmentioning

confidence: 99%

Skin prick test results of child patients diagnosed as bronchial asthma

Mısırlıoğlu

Cengizlier

2007

Allergologia et Immunopathologia

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“…By convention the proteins that represent important allergens in grass pollen are divided into major allergen groups [2, 3], a major allergen being by definition an allergen towards which the majority of allergic patients reacts. The groups I and V are estimated to represent the most important allergen groups [1] as they have been shown to possess the highest frequency and strength of IgE reactivity [1, 4, 5].…”

Section: Introductionmentioning

confidence: 99%

Characterization of immunoglobulin E responses in Balb/c mice against the major allergens of timothy grass (Phleum pratense) pollen

Seitzer¹,

Bussler

Kullmann³

et al. 2003

Clin Experimental Allergy

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The IgE reactivity induced by the major allergens in Balb/c mice was very similar to that found in allergic patients, with the exception of Phl p 1. The kinetics of the specific IgE response was comparable using either pollen extract or the purified major allergens, indicating that the intrinsic properties of the allergens are of importance rather than their proportionate amounts in pollen extract. This model should prove to be suitable for investigations regarding the mechanisms of induction and manifestation of timothy grass pollen allergy and for the evaluation of therapeutic strategies.

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“…About half of all allergic patients are sensitized towards grass-pollen proteins. Phlp 5b (derived from Phleum pratense, timothy grass) is one of the most relevant of these molecules and causes allergies in the majority of sensitized patients (Wissenbach et al, 1998). No speci®c features of these molecules have been identi®ed so far that explain why these pollen-protein molecules induce an allergic in¯ammatory response.…”

Section: Introductionmentioning

confidence: 99%

Structure of the functional domain of the major grass-pollen allergen Phlp 5b

Rajashankar

Bufe

Weber

et al. 2002

Acta Crystallogr D Biol Cryst

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The major allergen Phlp 5b from timothy grass pollen induces allergic rhinitis and bronchial asthma in millions of allergic patients worldwide. As an important step towards understanding the interactions between the pollen protein and components of the human immune system, the structure of the C-terminal key domain of Phlp 5b has been determined at 2.0 A resolution and refined to an R value of 19.7%. This is the first known allergen composed entirely of alpha-helices. The protein forms a dimer stabilized by one intermolecular disulfide bridge. Sequence homology suggests that at least all group V and group VI grass-pollen allergens belong to this new class of 'four-helix-bundle allergens'.

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Grass pollen allergens: new developments

Cited by 8 publications

References 31 publications

Skin prick test results of child patients diagnosed as bronchial asthma

Skin prick test results of child patients diagnosed as bronchial asthma

Characterization of immunoglobulin E responses in Balb/c mice against the major allergens of timothy grass (Phleum pratense) pollen

Structure of the functional domain of the major grass-pollen allergen Phlp 5b

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