Grass Carp Reovirus VP56 Allies VP4, Recruits, Blocks, and Degrades RIG-I to More Effectively Attenuate IFN Responses and Facilitate Viral Evasion

Su, Hang; Liao, Zhiwei; Yang, Chunrong; Zhang, Yongan; Su, Jian

doi:10.1128/spectrum.01000-21

Cited by 15 publications

(8 citation statements)

References 58 publications

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Section: Immune Escape Mechanisms By Aqrvsmentioning

confidence: 99%

“…The NS79 protein of GCRV‐106 decreased the TBK1‐triggered phosphorylation of IRF3/7 via being competitively phosphorylated by TBK1 143 . Furthermore, the VP56 protein of GCRV‐II strain GCRV‐097 targeted the phosphorylated IRF3/7 for ubiquitination and degradation 142,158 . Overexpression of VP56 remarkably degraded the phosphorylated IRF7 through K48‐linked ubiquitination, however, the exact mechanism that VP56 attenuated the protein expression and phosphorylation of IRF3 was still unclear.…”

Section: Immune Escape Mechanisms By Aqrvsmentioning

confidence: 99%

“…143 Furthermore, the VP56 protein of GCRV-II strain GCRV-097 targeted the phosphorylated IRF3/7 for ubiquitination and degradation. 142,158 Overexpression of VP56 remarkably degraded the phosphorylated IRF7 through K48-linked ubiquitination, however, the exact mechanism that VP56 attenuated the protein expression and phosphorylation of IRF3 was still unclear. Finally, the NS38 protein of GCRV-I strain GCRV-873 could interact with piscine TBK1 and IRF3 to inhibit the formation of TBK1-IRF3 complex, whereas NS80 interacted with piscine TBK1 and TRAF3 to inhibit the formation of TBK1-TRAF3 complex.…”

Section: Antagonism Of Key Signalling Proteins Downstream Of Prrsmentioning

confidence: 99%

“…The VP4 and VP56 proteins of GCRV-II strain GCRV-097 could interact with RIG-I and promote K48-linked ubiquitination of RIG-I to degrade RIG-I. As a consequence, antiviral effectors were suppressed, resulting in immune evasion for AqRV 141,142. In addition, VP56 binds to VP4 in the cytosol, synergistically enhancing the degradation of RIG-I and more efficiently facilitating viral evasion 142.…”

mentioning

confidence: 99%

“…As a consequence, antiviral effectors were suppressed, resulting in immune evasion for AqRV 141,142. In addition, VP56 binds to VP4 in the cytosol, synergistically enhancing the degradation of RIG-I and more efficiently facilitating viral evasion 142. MAVS is crucial for both RIG-I-mediated and MDA5-mediated signalling, many viral and host factors are utilised by viruses for degrading MAVS.…”

mentioning

confidence: 99%

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Structure, function and immune evasion strategies of aquareoviruses, with focus on grass carp reovirus

Zhang

Chang

2023

Reviews in Aquaculture

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Aquareoviruses (AqRVs) can infect various wild or cultured bony fishes with serious muscle and viscera haemorrhage syndrome and have caused severe economic losses worldwide. Accumulating evidences have revealed the functions of viral proteins of AqRVs in RNA transcription, virion assembly, cell attachment and/or viral replication. In addition, structural information and transcription mechanism of AqRVs have been in‐depth studied through cryo‐electron microscopy combined with three‐dimensional image reconstruction. Although far from enough, structural and functional studies of AqRVs provide substantial insights into how viral proteins coordinate the replication of AqRVs and escape the host immune response. Grass carp reovirus (GCRV) is the most pathogenic AqRV isolated from aquatic animals. The completion of GCRV lifecycle requires the participation of host proteins. So far, many host factors involved in the entry and replication of GCRV have been identified. Based on the function of viral proteins and the viral lifecycle, many vaccines and antiviral agents have been developed to prevent the replication and infection of GCRV. This review summarises the structural characteristics and the composition of core proteins of AqRVs, as well as synergistic mechanisms of structural proteins on genome transcription and virus entry of AqRVs. In addition, the review highlights our current knowledge for the infection and replication, functions of non‐structural proteins, immune escape mechanisms, as well as the vaccines and antiviral agents of AqRVs, especially for GCRV. A better understanding of structure, function and immune evasion strategies of AqRVs will offer new targets for prevention and control of AqRVs in aquaculture.

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Section: Immune Escape Mechanisms By Aqrvsmentioning

confidence: 99%

Section: Immune Escape Mechanisms By Aqrvsmentioning

confidence: 99%