Grasping tools: Effects of task and apraxia

Randerath, Jennifer; Li, Yong; Goldenberg, Georg; Hermsdörfer, Joachim

doi:10.1016/j.neuropsychologia.2008.10.005

Cited by 77 publications

(57 citation statements)

References 40 publications

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“…Therefore, errors in the perception of object manipulation can occur after damage external to left IPL, suggesting that the ventro-dorsal stream can be indirectly disturbed by disrupting communication at different parts of the pathway. These findings support previous research confirming that lesions implicating the left IPL can give rise to apraxia and result in impaired perception of object-use manipulation Daprati & Sirigu, 2006;Buxbaum et al, 2007;Goldenberg 2009;Ishibashi et al, 2011). They also suggest that apraxia may be associated with deficits in motor imagery, which in turn compromise the integration of known and visual object properties.…”

Section: * Discussionsupporting

confidence: 90%

“…The relationship between apraxia and left IPL damage implies that apraxic symptoms may reflect a disruption to the ventro-dorsal stream resulting in impaired access to internal motor representations necessary for accurate perception of object-use manipulation (Haaland, Harrington, & Knight, 2000;Buxbaum & Saffran, 2002;Randerath, Li, Goldenberg, & Hermsdörfer, 2009;Buxbaum & Kalénine, 2010). Akin to the dissociations found in neuroimaging data, apraxic patients make errors matching objects manipulated similarly (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Perceptual decisions regarding object manipulation are selectively impaired in apraxia or when tDCS is applied over the left IPL

et al. 2016

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This study evaluated whether apraxia can be understood as due to impaired motor representations or motor imagery necessary for appropriate object-use, imitation, and pantomime. The causal role of the left inferior parietal lobe (IPL), which is heavily implicated in apraxia, is also evaluated. These processes are appraised in light of the proposed ventro-dorsal sub-stream of the classic two visual pathway model, where perceptual information from the ventral stream and the dorsal action stream are integrated and essential for object manipulation. Using a task assessing object-use perception, stroke patients with apraxia demonstrated a selective deficit during perceptual decisions reliant on the integration of visible and known object properties to select the appropriate grasp for object-use. This deficit increased with apraxia severity. A dissociation was evident in these patients showing intact non-motoric perceptual decisions regarding the functional semantic relationship between two objects in the absence of the actor (e.g. how a hammer hits a nail). Converging evidence was found using a modified version of the same task in a neuromodulation study that directly targeted the left IPL in healthy participants using transcranial direct current stimulation (tDCS). Application of inhibitory stimulation over the left IPL reduced performance during perceptual decisions regarding object manipulation whilst performance was unaffected during functional semantic decisions. Excitatory stimulation of the left IPL did not affect performance in either task. Combined, these results suggest that the left inferior parietal lobe is critical for motor imagery, and that apraxia may be caused by an inability to use internal motor representations of object manipulation. These results are discussed in terms of motoric and non-motoric perceptual processes and the proposal of an additional ventro-dorsal sub-stream within the dorsal and ventral visual pathways model

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Section: * Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Perceptual decisions regarding object manipulation are selectively impaired in apraxia or when tDCS is applied over the left IPL

et al. 2016

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“…Further evidence for this integration of semantics into sensorymotor control of action can be found in the fact that conceptual knowledge influences the way people spontaneously grasp familiar tools [24]. Importantly, this effect can be disrupted in patients with left but not right side brain damage [25]. Based on these findings, it has been proposed that the unique human abilities of designing and using complex tools originate from adaptations of sensory-motor networks and their integration with cognitive processes pertaining to semantic knowledge about tools, the agent's intentions and contextual information about the task, most of these being also supported by the left hemisphere [26].…”

Section: Introductionmentioning

confidence: 99%

A neuropsychological perspective on the link between language and praxis in modern humans

Roby-Brami

Hermsdörfer

Roy

et al. 2012

Phil. Trans. R. Soc. B

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6University Claude Bernard Lyon 1, 43 boulevard du 11 novembre 1918, 69622 Villeurbanne, FranceHypotheses about the emergence of human cognitive abilities postulate strong evolutionary links between language and praxis, including the possibility that language was originally gestural. The present review considers functional and neuroanatomical links between language and praxis in brain-damaged patients with aphasia and/or apraxia. The neural systems supporting these functions are predominantly located in the left hemisphere. There are many parallels between action and language for recognition, imitation and gestural communication suggesting that they rely partially on large, common networks, differentially recruited depending on the nature of the task. However, this relationship is not unequivocal and the production and understanding of gestural communication are dependent on the context in apraxic patients and remains to be clarified in aphasic patients. The phonological, semantic and syntactic levels of language seem to share some common cognitive resources with the praxic system. In conclusion, neuropsychological observations do not allow support or rejection of the hypothesis that gestural communication may have constituted an evolutionary link between tool use and language. Rather they suggest that the complexity of human behaviour is based on large interconnected networks and on the evolution of specific properties within strategic areas of the left cerebral hemisphere.

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“…Eight different tools were presented, and the patients were requested to demonstrate their use. A detailed description of the test and the scoring system used can be found in Randerath et al (2009Randerath et al ( , 2011. As expected, LBD patients scored worse than RBD patients (LBD: mean = 71.05%, range: 0-100%, RBD: mean = 99.2%, range: 97-100%).…”

Section: Subjectsmentioning

confidence: 55%

“…As expected, LBD patients scored worse than RBD patients (LBD: mean = 71.05%, range: 0-100%, RBD: mean = 99.2%, range: 97-100%). Using a cutoff that distinguishes patients with severe to moderate apraxia (\80%) from patients with no or mild apraxia Randerath et al 2009), 11 patients were classified as apraxic and 12 as non-or only mildly apraxic. Aphasia was present in all beside one LBD patient, but all patients were able to follow the instructions for the task.…”

Section: Subjectsmentioning

confidence: 99%

Tool use without a tool: kinematic characteristics of pantomiming as compared to actual use and the effect of brain damage

Hermsdörfer

Randerath

et al. 2012

Exp Brain Res

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Movement goals and task mechanics differ substantially between actual tool use and corresponding pantomimes. In addition, apraxia seems to be more severe during pantomime than during actual tool use. Comparisons of these two modes of action execution using quantitative methods of movement analyses are rare. In the present study, repetitive scooping movements with a ladle from a bowl into a plate were recorded and movement kinematics was analyzed. Brain-damaged patients using their ipsilesional hand and healthy control subjects were tested in three conditions: pantomime, demonstration with the tool only, and actual use in the normal context. Analysis of the hand trajectories during the transport component revealed clear differences between the tasks, such as slower actual use and moderate deficits in patients with left brain damage (LBD). LBD patients were particularly impaired in the scooping component: LBD patients with apraxia exhibited reduced hand rotation at the bowl and the plate. The deficit was most obvious during pantomime but actual use was also affected, and reduced hand rotation was consistent across conditions as indicated by strong pair-wise correlations between task conditions. In healthy control subjects, correlations between movement parameters were most evident between the pantomime and demonstration conditions but weak in correlation pairs involving actual use. From these findings and published neuroimaging evidence, we conclude that for a specific tool-use action, common motor schemas are activated but are adjusted and modified according to the actual task constraints and demands. An apraxic LBD individual can show a deficit across all three action conditions, but the severity can differ substantially between conditions.

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Grasping tools: Effects of task and apraxia

Cited by 77 publications

References 40 publications

Perceptual decisions regarding object manipulation are selectively impaired in apraxia or when tDCS is applied over the left IPL

Perceptual decisions regarding object manipulation are selectively impaired in apraxia or when tDCS is applied over the left IPL

A neuropsychological perspective on the link between language and praxis in modern humans

Tool use without a tool: kinematic characteristics of pantomiming as compared to actual use and the effect of brain damage

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