Graphics Processing Unit-Based Bioheat Simulation to Facilitate Rapid Decision Making Associated with Cryosurgery Training

Keelan, Robert; Zhang, Hong; Shimada, Kenji; Rabin, Yoed

doi:10.1177/1533034615580694

Cited by 21 publications

(33 citation statements)

References 33 publications

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“…The PFAM is computationally inexpensive, which required less than 0.5 s for any of the cases presented above. As described in [27], the TFRM is solved by applying a sparse matrix format and internal solvers for efficiency in calculations, with a typical runtime under 3 s. These runtime numbers represent non-optimized computation frameworks, where GPU implementation is likely to reduce the overall runtime to milliseconds [9]. Hence, the integrated numerical scheme is relevant for clinical practice and warrants further development.…”

Section: Resultsmentioning

confidence: 99%

A new method for temperature-field reconstruction during ultrasound-monitored cryosurgery using potential-field analogy

2016

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The current study aims at developing computational tools in order to gain information about the thermal history in areas invisible to ultrasound imaging during cryosurgery. This invisibility results from the high absorption rate of the ultrasound energy by the frozen region, which leads to an apparent opacity in the cryotreated area and a shadow behind it. A proof-of-concept for freezing-front estimation is demonstrated in the current study, using the new potential-field analogy method (PFAM). This method is further integrated with a recently developed temperature-field reconstruction method (TFRM) to estimate the temperature distribution within the frozen region. This study uses prostate cryosurgery as a developmental model and trans-rectal ultrasound imaging as a choice of practice. Results of this study indicate that the proposed PFAM is a viable and computationally inexpensive solution to estimate the extent of freezing in the acoustic shadow region. Comparison of PFAM estimations and experimental data shows an average mismatch of less than 2 mm in freezing-front location, which is comparable to the uncertainty in ultrasound imaging. Comparison of the integrated PFAM+TFRM scheme with a full-scale finite-elements analysis (FEA) indicates an average mismatch of 0.9 mm for the freezing front location and 0.1 mm for the lethal temperature isotherm of −45°C. Comparison of the integrated PFAM+TFRM scheme with experimental temperature measurements show a difference in the range of 2°C and 6°C for selected points of measurement. Results of this study demonstrate the integrated PFAM+TFRM scheme as a viable and computationally inexpensive means to gain information about the thermal history in the frozen region during ultrasound-monitored cryosurgery.

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Section: Resultsmentioning

confidence: 99%

A new method for temperature-field reconstruction during ultrasound-monitored cryosurgery using potential-field analogy

2016

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“…Note that planning solutions were not given at the end of the pretest on the same cases. The applied thermal history was selected to simulate the cooling capabilities of Joule-Thomson based cryoprobes, as discussed in detail in (13,19). …”

Section: Methodsmentioning

confidence: 99%

“…Of the 17 residents, 12 (71%) were male, 5 (29%) were female, not by choice but due to the current demographics of the surgical residency program at AHN. All bioheat transfer simulations and defect calculations were performed with a recently developed, GPU-based code, with a typical runtime of a few seconds on personal workstations located at the Biothermal Technology Laboratory (BTTL), at Carnegie Mellon University (19). In order to make use of superior computation capabilities at the BTTL while benefiting from the unique educational environment at the STAR Center, human subject studies were performed by means of remote networking between the AHN and the BTTL, using a framework that further signifies the potential for internet-based training.…”

Section: Methodsmentioning

confidence: 99%

Simulation-Based Cryosurgery Training

Sehrawat

Keelan

Shimada

et al. 2016

Technol Cancer Res Treat

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A proof-of-concept for an advanced-level computerized training tool for cryosurgery is demonstrated, based on three-dimensional cryosurgery simulations and a variable insertion-depth strategy for cryoprobes. The objective for system development is twofold: to identify a cryoprobe layout in order to best-match a planning isotherm with the target region shape, and to verify that cryoprobe placement does not violate accepted geometric constraints. System validation has been performed by collecting training data from 17 surgical residents, having no prior experience or advanced knowledge of cryosurgery. This advanced-level study includes an improved training-session design, in order to enhance knowledge dissemination and elevate participant motivation to excel. In terms of match between a planning isotherm and the target region shape, results of this demonstrate trainee performance improvement from 4.4% in a pretest to 44.4% in a posttest over a course of 50 minutes of training. In terms of combined performance, including the above geometrical match and constraints on cryoprobe placement, this study demonstrates trainee performance improvement from 2.2% in the pretest to 31.1% in the posttest. Given the relatively short training session and the lack of prior knowledge, these improvements are significant and encouraging. These results are of particular significance, as they have been obtained from a surgical resident population, which are exposed to the typical stress and constraints in advanced surgical education.

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“…The majority of those efforts have focused on computation methods to plan the cryoprobe layout 6,7,8–12, , while more sporadic efforts addressed simulation of TRUST guidance 13 , prostate model reconstruction 14,15 , and acceleration of bioheat transfer simulations 16,17 . Unfortunately, since prostate cryosurgery is yet to be standardized, the computational means are yet to be reduced to practice.…”

Section: Introductionmentioning

confidence: 99%

A computerized tutor prototype for prostate cryotherapy: key building blocks and system evaluation

et al. 2017

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This paper focuses on the evaluation of a prototype for a computer-based tutoring system for prostate cryosurgery, while reviewing its key building blocks and their benchmark performance. The tutoring system lists geometrical constraints of cryoprobe placement, displays a rendered shape of the prostate, simulates cryoprobe insertion, enables distance measurements, simulates the corresponding thermal history, and evaluates the mismatch between the target region shape and a pre-selected planning isotherm. The quality of trainee planning is measured in comparison with a computer-generated plan, created for each case study by a previously developed planning algorithm, known as bubble-packing. While the tutoring level in this study aims only at geometrical constraints on cryoprobe placement and the resulting thermal history, it creates a unique opportunity to gain insight into the process outside of the operation room. System validation of the tutor has been performed by collecting training data from surgical residents, having no prior experience or advanced knowledge of cryotherapy. Furthermore, the system has been evaluated by graduate engineering students having no formal education in medicine. In terms of match between a planning isotherm and the target region shape, results demonstrate medical residents’ performance improved from 4.4% in a pretest to 37.8% in a posttest over a course of 50 minutes of training (within 10% margins from a computer-optimized plan). Comparing those results with the performance of engineering students indicates similar results, suggesting that planning of the cryoprobe layout essentially revolves around geometric considerations.

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Graphics Processing Unit-Based Bioheat Simulation to Facilitate Rapid Decision Making Associated with Cryosurgery Training

Cited by 21 publications

References 33 publications

A new method for temperature-field reconstruction during ultrasound-monitored cryosurgery using potential-field analogy

A new method for temperature-field reconstruction during ultrasound-monitored cryosurgery using potential-field analogy

Simulation-Based Cryosurgery Training

A computerized tutor prototype for prostate cryotherapy: key building blocks and system evaluation

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