Graphic analysis of microscopic tumor cell infiltration, proliferative potential, and vascular endothelial growth factor expression in an autopsy brain with glioblastoma

Nagashima, Goro; Suzuki, Ryuta; Hokaku, Hiromu; Takahashi, M; Miyo, Takayasu; Asai, Jun-ichiro; Nakagawa, Nobuhiro; Fujimoto, Tsukasa

doi:10.1016/s0090-3019(98)00056-1

Cited by 42 publications

(38 citation statements)

References 35 publications

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“…Tumor cell infiltration is a critical feature of high-grade gliomas such as GBMs, but not of other tumors like juvenile pilocytic astrocytomas (JPAs), which usually lack the ability to infiltrate and are usually not fatal [15]. We have previously found that anti-β1 and anti-αv integrin antibodies inhibit migration of glioblastoma cell lines in vitro [16].…”

Section: Focal Adhesion Kinasementioning

confidence: 99%

Molecular Events Implicated in Brain Tumor Angiogenesis and Invasion

et al. 2000

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We have conducted studies designed to help elucidate the molecular mechanisms involved in brain tumor invasion and angiogenesis, which are critical in the growth of malignant tumors of the central nervous system. A variety of molecular factors have been implicated in these processes. Here we focus on three that are of particular importance in the progression of brain tumors. Angiopoietins are involved in the regulation of vascular development. Hypoxia inducible factor-1 is a transcription factor that up-regulates genes, including genes encoding vascular endothelial growth factor under hypoxic conditions. Focal adhesion kinase is associated with infiltration of tumor cells and angiogenesis.

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Section: Focal Adhesion Kinasementioning

confidence: 99%

Molecular Events Implicated in Brain Tumor Angiogenesis and Invasion

et al. 2000

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“…Despite complete surgical resection, recurrence happens in almost all cases, mostly at the margin of the resection cavity in the peritumoral brain zone (PBZ) [7,8]. It is widely believed that tumor cell infiltration into the PBZ may promote recurrence [9][10][11]. However, few cellular and molecular analyses have been performed in this area.…”

Section: Introductionmentioning

confidence: 99%

Characterizing the peritumoral brain zone in glioblastoma: a multidisciplinary analysis

et al. 2015

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Glioblastoma (GB) is the most frequent and aggressive type of primary brain tumor. Recurrences are mostly located at the margin of the resection cavity in the peritumoral brain zone (PBZ). Although it is widely believed that infiltrative tumor cells in this zone are responsible for GB recurrence, few studies have examined this zone. In this study, we analyzed PBZ left after surgery with a variety of techniques including radiology, histopathology, flow cytometry, genomic, transcriptomic, proteomic, and primary cell cultures. The resulting PBZ profiles were compared with those of the GB tumor zone and normal brain samples to identify characteristics specific to the PBZ. We found that tumor cell infiltration detected by standard histological analysis was present in almost one third of PBZ taken from an area that was considered normal both on standard MRI and by the neurosurgeon under an operating microscope. The panel of techniques used in this study show that the PBZ, similar to the tumor zone itself, is characterized by substantial inter-patient heterogeneity, which makes it difficult to identify representative markers. Nevertheless, we identified specific alterations in the PBZ such as the presence of selected tumor clones and stromal cells with tumorigenic and angiogenic properties. The study of GB-PBZ is a growing field of interest and this region needs to be characterized further. This will facilitate the development of new, targeted therapies for patients with GB and the development of approaches to refine the per-operative evaluation of the PBZ to optimize the surgical resection of the tumor.

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“…[21][22][23][24][25][26][27] Most interesting, there are few vascular abnormalities in the NE, FLAIR-hyperintense peritumoral regions on perfusion imaging, [21][22][23][24][25][26][27] despite the recognized infiltration of tumor cells into these areas. [28][29][30][31] Additional evidence suggests that edema surrounding the tumor originates directly from the CE tissue, passively diffuses into the NE regions, and may therefore not be associated with blood-brain barrier breakdown in the NE tissue. 32,33 Several intriguing studies have, however, identified decreased vascular reactivity outside CE regions of glioma.…”

Section: Discussionmentioning

confidence: 99%

Local Glioma Cells Are Associated with Vascular Dysregulation

Bowden

Gill

Englander

et al. 2018

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Malignant glioma is a highly infiltrative malignancy that causes variable disruptions to the structure and function of the cerebrovasculature. While many of these structural disruptions have known correlative histopathologic alterations, the mechanisms underlying vascular dysfunction identified by resting-state blood oxygen level-dependent imaging are not yet known. The purpose of this study was to characterize the alterations that correlate with a blood oxygen level-dependent biomarker of vascular dysregulation.

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Graphic analysis of microscopic tumor cell infiltration, proliferative potential, and vascular endothelial growth factor expression in an autopsy brain with glioblastoma

Cited by 42 publications

References 35 publications

Molecular Events Implicated in Brain Tumor Angiogenesis and Invasion

Molecular Events Implicated in Brain Tumor Angiogenesis and Invasion

Characterizing the peritumoral brain zone in glioblastoma: a multidisciplinary analysis

Local Glioma Cells Are Associated with Vascular Dysregulation

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