Graphene quantum dots disturbed the energy homeostasis by influencing lipid metabolism of macrophages

Shao, Yan; Wang, Xiaoyang; Wang, Liting; Huang, Youying; Wei, Quanfang; Sun, Wei; Lai, Xiaodan; Yang, Fan; Li, Fēi; Huang, Yi

doi:10.1016/j.tox.2022.153389

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…Additionally, macrophages exposed to GQDs increase the presence of phosphoglycerides, sphingolipids, and oxidized lipids ( Shao et al, 2023 ). While not completely elucidated, the role of host lipids and the changes associated with Mtb infection, play a key role in the pathogenesis of TB ( De Maio et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Unraveling the potential of graphene quantum dots against Mycobacterium tuberculosis infection

Santarelli,

Perini,

Salustri

et al. 2024

Front. Microbiol.

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IntroductionThe emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains has underscored the urgent need for novel therapeutic approaches. Carbon-based nanomaterials, such as graphene oxide (GO), have shown potential in anti-TB activities but suffer from significant toxicity issues.MethodsThis study explores the anti-TB potential of differently functionalized graphene quantum dots (GQDs) – non-functionalized, L-GQDs, aminated (NH2-GQDs), and carboxylated (COOH-GQDs) – alone and in combination with standard TB drugs (isoniazid, amikacin, and linezolid). Their effects were assessed in both axenic cultures and in vitro infection models.ResultsGQDs alone did not demonstrate direct mycobactericidal effects nor trapping activity. However, the combination of NH2-GQDs with amikacin significantly reduced CFUs in in vitro models. NH2-GQDs and COOH-GQDs also enhanced the antimicrobial activity of amikacin in infected macrophages, although L-GQDs and COOH-GQDs alone showed no significant activity.DiscussionThe results suggest that specific types of GQDs, particularly NH2-GQDs, can enhance the efficacy of existing anti-TB drugs. These nanoparticles might serve as effective adjuvants in anti-TB therapy by boosting drug performance and reducing bacterial counts in host cells, highlighting their potential as part of advanced drug delivery systems in tuberculosis treatment. Further investigations are needed to better understand their mechanisms and optimize their use in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Unraveling the potential of graphene quantum dots against Mycobacterium tuberculosis infection

Santarelli,

Perini,

Salustri

et al. 2024

Front. Microbiol.

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“…47,48 A recent study reported that graphene quantum dots upregulated phosphoglycerides, sphingolipids, and oxidized lipids in macrophages. 49 Similarly, polymeric nanoparticles (NPs) altered metabolic pathways related with glycerophospholipid, sphingolipid, linoleic acid, arginine and proline, and alpha-linolenic acid metabolisms in macrophages. 50 We reported that MWCNTs and graphene oxide upregulated Cer in endothelial cells 29 and human brain organoids, 51 which could be related with the cytotoxicity of the materials to these models.…”

Section: Discussionmentioning

confidence: 99%

Effects of multi‐walled carbon nanotubes and halloysite nanotubes on plasma lipid profiles and autophagic lipolysis pathways in mouse aortas and hearts

Cheng,

Zhang,

Wang

et al. 2024

Environmental Toxicology

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Multi‐walled carbon nanotubes (MWCNTs) and halloysite nanotubes (HNTs) are widely used tubular‐structured nanomaterials (NMs), but their cardiovascular effects are not clear. This study compared the effects of MWCNTs and HNTs on lipid profiles in mouse plasma and gene expression profiles in aortas and hearts. Mice were intravenously injected with 50 μg NMs, once a day, for 5 days. Then, the plasma was collected for lipidomics analysis, and aortas and hearts were collected for RNA‐sequencing analysis. While MWCNTs or HNTs did not induce obvious pathological changes in aortas or hearts, the lipid profiles in mouse plasma were altered. Further analysis revealed that MWCNTs more effectively upregulated sphingolipids and sterol lipids, whereas HNTs more effectively upregulated glycerophospholipids and fatty acyls. Consistently, RNA‐sequencing data indicated that MWCNTs and HNTs altered signaling pathways related with lipid synthesis and metabolism, as well as those related with endoplasmic reticulum, lysosomes and autophagy, more significantly in aortas than in hearts. We further verified the changes of proteins involved in autophagic lipolysis, that MWCNTs were more effectively to suppress the autophagic biomarker LC3, whereas HNTs were more effectively to affect lipid metabolism proteins. These results may provide novel understanding about the influences of MWCNTs and HNTs on lipid profiles and lipid signaling pathways in cardiovascular systems. Importantly, previous studies considered HNTs as biocompatible materials, but the results from this study suggested that both MWCNTs and HNTs were capable to affect lipid profiles and autophagic lipolysis pathways in cardiovascular systems, although their exact influences were different.

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Effects of graphene ZNO on macrophages adjuvant effect of reduced graphene layers modified with different concentrations of ZnO on mammalian macrophages

Önal,

Karatekin,

Ayaz

2024

Journal of Drug Delivery Science and Technology

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Graphene quantum dots disturbed the energy homeostasis by influencing lipid metabolism of macrophages

Cited by 5 publications

References 41 publications

Unraveling the potential of graphene quantum dots against Mycobacterium tuberculosis infection

Unraveling the potential of graphene quantum dots against Mycobacterium tuberculosis infection

Effects of multi‐walled carbon nanotubes and halloysite nanotubes on plasma lipid profiles and autophagic lipolysis pathways in mouse aortas and hearts

Effects of graphene ZNO on macrophages adjuvant effect of reduced graphene layers modified with different concentrations of ZnO on mammalian macrophages

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