Graphene quantum dots based MnFe2O4@SiO2 magnetic nanostructure as a pH-sensitive fluorescence resonance energy transfer (FRET) system to enhance the anticancer effect of the drug

Nejad, Zahra Kiani; Khandar, Ali Akbar; Khatamian, Massoumeh

doi:10.1016/j.ijpharm.2022.122254

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…As a proof-of-concept, we employed chiral GQDs as nanocarriers for small chemotherapy drugs (e.g., DOX) and investigated their delivery efficiency into tumor-like tissue. Due to its planar anthraquinone structure, chiral GQDs can be loaded with DOX via the π-π stacking ( Supplementary Figure S10 ) ( Liu et al, 2009 ; Wo et al, 2016 ; Askari et al, 2021 ; Sawy et al, 2021 ; Kiani Nejad et al, 2022 ; Mirzaei-Kalar et al, 2022 ). Two drug-loaded nanocarriers, L -GQD-DOX and D -GQD-DOX, were tested in mature cellular spheroids and compared to the controls (e.g., Non-treated, L -GQD-treated, and D -GQD-treated groups as negative controls; free DOX-treated group as a positive control).…”

Section: Resultsmentioning

confidence: 99%

“…Notably, the planar plane of GQDs mainly consists of aromatic rings, which makes them well-suited for loading small aromatic molecules, such as chemotherapy drugs ( Askari et al, 2021 ; Mirzaei-Kalar et al, 2022 ), through aromatic stacking (i.e., π-π stacking) ( Liu et al, 2009 ). This property enabled the development of GQDs as drug carriers for drug delivery that could effectively transport and release the loaded drugs to targeted cells or tissues with high selectivity and efficacy ( Liu et al, 2009 ; Wo et al, 2016 ; Askari et al, 2021 ; Kiani Nejad et al, 2022 ; Mirzaei-Kalar et al, 2022 ). The edges of GQDs can be engineered to contain desired functional groups, which enables covalent modification with chiral molecules, endowing nanoscale chirality ( Suzuki et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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Chirality-enhanced transport and drug delivery of graphene nanocarriers to tumor-like cellular spheroid

et al. 2023

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Chirality, defined as “a mirror image,” is a universal geometry of biological and nonbiological forms of matter. This geometry of molecules determines how they interact during their assembly and transport. With the development of nanotechnology, many nanoparticles with chiral geometry or chiroptical activity have emerged for biomedical research. The mechanisms by which chirality originates and the corresponding synthesis methods have been discussed and developed in the past decade. Inspired by the chiral selectivity in life, a comprehensive and in-depth study of interactions between chiral nanomaterials and biological systems has far-reaching significance in biomedicine. Here, we investigated the effect of the chirality of nanoscale drug carriers, graphene quantum dots (GQDs), on their transport in tumor-like cellular spheroids. Chirality of GQDs (L/D-GQDs) was achieved by the surface modification of GQDs with L/D-cysteines. As an in-vitro tissue model for drug testing, cellular spheroids were derived from a human hepatoma cell line (i.e., HepG2 cells) using the Hanging-drop method. Our results reveal that the L-GQDs had a 1.7-fold higher apparent diffusion coefficient than the D-GQDs, indicating that the L-GQDs can enhance their transport into tumor-like cellular spheroids. Moreover, when loaded with a common chemotherapy drug, Doxorubicin (DOX), via π-π stacking, L-GQDs are more effective as nanocarriers for drug delivery into solid tumor-like tissue, resulting in 25% higher efficacy for cancerous cellular spheroids than free DOX. Overall, our studies indicated that the chirality of nanocarriers is essential for the design of drug delivery vehicles to enhance the transport of drugs in a cancerous tumor.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chirality-enhanced transport and drug delivery of graphene nanocarriers to tumor-like cellular spheroid

et al. 2023

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“…Kiani Nejad et al prepared a nanoplatform by conjugating MnFe 2 O 4 , SiO 2 , and GQDs to improve the effect of the anticancer drug daunorubicin and a pH‐dependent drug release. The study indicated that the drug‐loaded nanoplatform can induce MCF‐7 cell apoptosis following growth inhibition of more than 95% of cells (Kiani Nejad et al, 2022). Au et al prepared composites of GQDs and the anticancer drug vinblastine.…”

Section: Carbon Quantum Dots In Drug Deliverymentioning

confidence: 99%

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Das,

Roy,

Saha

2024

Biotech & Bioengineering

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The carbon‐based nanostructures have led to the development of theranostic nanoplatforms for simultaneous diagnosis and therapy due to their effective cell membrane‐penetration ability, low degree of cytotoxicity, excellent pore volume, substantial chemical stability, and reactive surface. In the last few years, extensive efforts were made to design multifunctional nanoplatform strategies based on carbon nanostructures, involving multimodal imaging, controlled drug release capabilities, sensing in vitro, efficient drug loading capacity, and therapy. Carbon and graphene quantum dots (CQDs and GQDs) were the recent entrants, contingently being assessed for drug delivery and bioimaging. With the advancements, these quantum dots have ignited remarkable research interest and are now widely evaluated for diagnosis, bioimaging, sensing, and drug delivery applications. The last decade has witnessed their remarkable electrical, optical, and biocompatible properties since their inception. It is presumed that both of them have high potential as drug carriers and would serve as the next generation of approaches to address numerous unresolved therapeutic challenges. This review examined the recent advances of CQD and GQD based drug delivery applications, challenges, and future perspectives to pave the way for further studies in the future.

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“…Conjugates of quantum dots with macromolecular chains are widely used as biological nanoprobes, as well as in the elements of various chemical sensors based on the use of the Förster energy transfer between nanoobjects connected by a macrochain [1][2][3][4][5][6][7][8][9]. In this aspect, of great interest is the control of the characteristics of such functional nanosystems by the action of an external electric field [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Conformational Structure of an Adsorbed Polyelectrolyte on a Nanoparticle With Low Conductivity in an Alternating Electric Field

M.G. Kucherenko

2023

Eurasian phys. tech. j.

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An analytical form of the model of the quasi-equilibrium conformational structure of the units of the Gaussian chain of a polyelectrolyte adsorbed on a nanospheroid witha relatively low electrical conductivity (undoped semiconductor) polarized in an external harmonically varying quasi-static electric field with a frequency significantly lower than the plasma frequency of the nanoparticle material is proposed. Variants ofthe model are discussed that go beyond the scope of the quasi-static approximation, i.e., take into account the effects of delay, the manifestation of which will be noticeable in the case of sufficiently extended nanostructures. Electrically induced conformational changes of generally neutral polyampholytic polypeptides on the surface of a spherical germanium nanoparticle in a static or alternating external electric field have been studied by molecular dynamics. In a static electric field, in the case of asmall distance between the charged units in the polyampholyte, a large number of macrochain loops were formed, elongated in the direction of the polarization axis of the nanoparticle. If the distance between the oppositely charged amino acid residues of the polypeptide exceeded the diameter of the nanoparticle, the charged units were mainly localized in the oppositely charged subpolar regions of the polarized germanium nanoparticle. In an alternating electric field, a girdle polyampholyte edge was formed in the equatorial region of the nanoparticle, the macrochain links of which were desorbed from the surface with an increase in the amplitude of the polarizing alternating electric field.

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Graphene quantum dots based MnFe2O4@SiO2 magnetic nanostructure as a pH-sensitive fluorescence resonance energy transfer (FRET) system to enhance the anticancer effect of the drug

Cited by 6 publications

References 43 publications

Chirality-enhanced transport and drug delivery of graphene nanocarriers to tumor-like cellular spheroid

Chirality-enhanced transport and drug delivery of graphene nanocarriers to tumor-like cellular spheroid

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Conformational Structure of an Adsorbed Polyelectrolyte on a Nanoparticle With Low Conductivity in an Alternating Electric Field

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