Graphene quantum dots based magnetic nanoparticles as a promising delivery system for controlled doxorubicin release

Javadian, Soheila; Najafi, Khadijeh; Sadrpoor, S. Morteza; Ektefa, Fatemeh; Dalir, Nima; Nikkhah, Maryam

doi:10.1016/j.molliq.2021.115746

Cited by 21 publications

(13 citation statements)

References 45 publications

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“…The cellular uptake of GRQDs, loaded into layered double hydroxide (LDH) NPs by rat bone marrow derived mesenchymal stem cells (MSCs), increased the endocytosis and phenotypic transition of macrophage in LDH-GRQD nanocomposites and was easier, due to inflammatory regulation of LDH, suggesting therapeutic potential of such nanocomposites to be used in bone defects regeneration [ 100 ]. Polyethylene glycol (PEG)-functionalized GRQDs-based magnetic NPs, which can function as a superb delivery system, for the controlled release of anticancer drugs as well as imaging agents for cancer cells [ 101 ], plus targeted curcumine (CUR) delivery and cancer cell imaging were also observed, using CUR-loaded GRQDs decorated with hyaluronic acid, which were adsorbed on HeLa cells, unlike L929 cells, and greatly inhibited HeLa cell viability [ 102 ]. PEG-GRQDs, conjugated with herceptin (HER) and DOX-loaded β-cyclodextrin, were designed by Ko et al [ 103 ], for the treatment of human epidermal growth-factor receptor 2 (HER2)-positive breast cancer.…”

Section: Gbns As Drugs and Nanocarriersmentioning

confidence: 99%

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Jampílek

Kráľová

2022

IJMS

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Climate change and increasing contamination of the environment, due to anthropogenic activities, are accompanied with a growing negative impact on human life. Nowadays, humanity is threatened by the increasing incidence of difficult-to-treat cancer and various infectious diseases caused by resistant pathogens, but, on the other hand, ensuring sufficient safe food for balanced human nutrition is threatened by a growing infestation of agriculturally important plants, by various pathogens or by the deteriorating condition of agricultural land. One way to deal with all these undesirable facts is to try to develop technologies and sophisticated materials that could help overcome these negative effects/gloomy prospects. One possibility is to try to use nanotechnology and, within this broad field, to focus also on the study of two-dimensional carbon-based nanomaterials, which have excellent prospects to be used in various economic sectors. In this brief up-to-date overview, attention is paid to recent applications of graphene-based nanomaterials, i.e., graphene, graphene quantum dots, graphene oxide, graphene oxide quantum dots, and reduced graphene oxide. These materials and their various modifications and combinations with other compounds are discussed, regarding their biomedical and agro-ecological applications, i.e., as materials investigated for their antineoplastic and anti-invasive effects, for their effects against various plant pathogens, and as carriers of bioactive agents (drugs, pesticides, fertilizers) as well as materials suitable to be used in theranostics. The negative effects of graphene-based nanomaterials on living organisms, including their mode of action, are analyzed as well.

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Section: Gbns As Drugs and Nanocarriersmentioning

confidence: 99%

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Jampílek

Kráľová

2022

IJMS

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“…To overcome these challenges, drug delivery systems (DDS), such as quantum dots, 11 mesoporous silica, 12 nanoparticles, 13 dendrimers, 14 and liposomes, 15 have extensively been studied. Still, their applications are hindered by the limitations of premature degradability, undue toxicity, and lower drug loading capacities.…”

Section: Introductionmentioning

confidence: 99%

Programmable Drug Release from a Dual-Stimuli Responsive Magnetic Metal–Organic Framework

2022

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Along with the increasing incidence of cancer and drawbacks of traditional drug delivery systems (DDSs), developing novel nanocarriers for sustained targeted-drug release has become urgent. In this regard, metal–organic frameworks (MOFs) have emerged as potential candidates due to their structural flexibility, defined porosity, lower toxicity, and biodegradability. Herein, a FeMn-based ferromagnetic MOF was synthesized from a preassembled Fe 2 Mn(μ 3 -O) cluster. The introduction of the Mn provided the ferromagnetic character to FeMn-MIL-88B. 5-Fluoruracil (5-FU) was encapsulated as a model drug in the MOFs, and its pH and H 2 S dual-stimuli responsive controlled release was realized. FeMn-MIL-88B presented a higher 5-FU loading capacity of 43.8 wt % and rapid drug release behavior in a tumor microenvironment (TME) simulated medium. The carriers can rapidly release loaded drug of 70% and 26% in PBS solution (pH = 5.4) and NaHS solution (500 μM) within 24 h. The application of mathematical release models indicated 5-FU release from carriers can be precisely fitted to the first-order, second-order, and Higuchi models of release. Moreover, the cytotoxicity profile of the carrier against human embryonic kidney cells (HEK293T) suggests no adverse effects up to 100 μg/mL. The lesser toxic effect on cell viability can be attributed to the low toxicity values [LD 50 (Fe) = 30 g·kg –1 , (Mn) = 1.5 g·kg –1 , and (terephthalic acid) = 5 g·kg –1 ] of the MOFs structural components. Together with dual-stimuli responsiveness, ferromagnetic nature, and low toxicity, FeMn-MIL-88B MOFs can emerge as promising carriers for drug delivery applications.

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“…16 A large scale synthesis was achieved using the coprecipitation method to prepare iron oxide NPs by aging a stoichiometric mixture of inorganic salts in basic aqueous media and controlling the aging condition. However, these magnetic materials with particle size smaller than 100 nm have been intensively used in many technology applications, among others, 1,[17][18][19][20][21][22][23][24][25][26][27][28][29][30] although the fabrication of their surface with appropriate coating and functional groups or molecules are desired for good performance coupled with target agents. Especially, the core-shell fabrication will prevent the multistep conjugations to a single component NP as well as avoid conjugated different molecules and low loading on the NP surface, which may interfere with targeting capabilities.…”

Section: Introductionmentioning

confidence: 99%