Graphene quantum dots as effective probes for label-free fluorescence detection of dopamine

Zhao, Jingjin; Zhao, Limin; Lan, Chuanqing; Zhao, Shulin

doi:10.1016/j.snb.2015.09.105

Cited by 188 publications

(75 citation statements)

References 40 publications

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“…The possible mechanism by which FL quenching occurs in the proposed sensing strategy can be explained by the oxidation of the HQ, in an alkaline and oxygenated environment, generating BQ, which, in turn, quenches GQDs FL. The important contribution of the catalytic role of GQDs in this oxidation process has been previously reported . The produced quinone acted as an electron acceptor with consequent FL quenching of the GQDs .…”

Section: Resultsmentioning

confidence: 71%

“…The important contribution of the catalytic role of GQDs in this oxidation process has been previously reported . The produced quinone acted as an electron acceptor with consequent FL quenching of the GQDs . Hence, this decrease of FL can be related with ALP concentration.…”

Section: Resultsmentioning

confidence: 72%

“…However, in vial E, where GQDs are present, a darker brown color was observed, suggesting a catalytic role of GQDs in BQ formation. Different researchers have reported peroxidase‐mimicking catalytic activity to GQDs as well as an electron transfer process from the photo‐excited QDs (donor) to the quinone (in this case, BQ) in solution (acceptor), which ultimately results in a FL quenching due to a surface state change . Under UV light (Figure c) all the observed FL correspond to the vials where no enzymatic reaction, in presence of GQDs, took place (i.e.…”

Section: Resultsmentioning

confidence: 91%

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Quenching of graphene quantum dots fluorescence by alkaline phosphatase activity in the presence of hydroquinone diphosphate

et al. 2018

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In this work, a turn-off photoluminescent sensing proof-of-concept based on blue luminescent graphene quantum dots (GQDs) as the fluorescent probe was developed. For that purpose, GQDs optical response was related with the catalytic enzymatic activity of alkaline phosphatase (ALP), in the presence of hydroquinone diphosphate (HQDP). The hydrolysis of HQDP by ALP generated hydroquinone (HQ). The oxidation of HQ, enzymatically produced, to p-benzoquinone (BQ) resulted in the quenching of GQDs fluorescence (FL). Therefore, the developed luminescent sensing mechanism allowed the FL quenching with ALP activity to be related and thus quantified the concentration of ALP down to 0.5 nM of enzyme. This innovative design principle appears as a promising tool for the development of enzymatic sensors based on ALP labeling with fluorescent detection or even for direct ALP luminescent quantification in an easy, fast and sensitive manner.

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Section: Resultsmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 91%

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Quenching of graphene quantum dots fluorescence by alkaline phosphatase activity in the presence of hydroquinone diphosphate

et al. 2018

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“…[1,2] Diagnosis of these diseases necessitates very accurate measurements of DA in biological samples. The optical analysis such as fluorescence [3][4][5] and electrochemiluminescence (ECL) analysis [6,7] with the high sensitivity and good selectivity can be applied to detect DA via the luminescence or ECL quenching. However, the quenching phenomenon introduced by DA might be the false positive result because the interferents in bio-samples may quench the luminescence synchronously.…”

Section: Introductionmentioning

confidence: 99%

Intercalation Lithium Cobalt Oxide for the Facile Fabrication of a Sensitive Dopamine Sensor

Gao

Liang

et al. 2020

ChemElectroChem

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Intercalation lithium cobalt oxide (LCO) with the properties of insertion and de‐intercalation of Li+ was utilized to fabricate the sensitive dopamine (DA) sensor, which has excellent adsorption and catalytic behavior. LCO mixed with graphite powder (LCO−G) for individual and simultaneous determination of DA and uric acid (UA) achieved the low detection limits and the wide concentration ranges without the interference of ascorbic acid (AA). For individual detection, the linear responses of DA and UA were in the concentration ranges of 0.020–20 μM and 0.500–200 μM with the detection limits of 4.0 nM and 0.18 μM (s/n=3), respectively. For simultaneous detection with UA and AA by the change of the concentrations of DA, the linear response ranges were 0.050–20 μM with the detection limit of 7.9 nM (s/n=3). The LCO−G/GCE was further applied to the detection of DA in human serum to illustrate its potential of highly sensitive and selective electrochemical sensing.

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“…Notably, due to the quantum confinement and edge effects, GQDs exhibit high Photoluminescence and slow hot-carrier relaxation [4][5]. With these advantages, GQDs have better performance comparing to conventional semiconductor in Qcatalytic reactions [6], conductive material [7], detection ions [8], probes [9] and bioimaging [10]. GQDs with heteroatom doping are able to improve some properties of materials or instruments [11].…”

Section: Introductionmentioning

confidence: 99%

Effective Conductivity of Graphene Quantum Dots Solution

Chen¹,

Peng²,

Li³

et al. 2018

Proceedings of the 4th Annual International Conference on Material Engineering and Application (ICMEA 2017)

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Graphene quantum dots as effective probes for label-free fluorescence detection of dopamine

Cited by 188 publications

References 40 publications

Quenching of graphene quantum dots fluorescence by alkaline phosphatase activity in the presence of hydroquinone diphosphate

Quenching of graphene quantum dots fluorescence by alkaline phosphatase activity in the presence of hydroquinone diphosphate

Intercalation Lithium Cobalt Oxide for the Facile Fabrication of a Sensitive Dopamine Sensor

Effective Conductivity of Graphene Quantum Dots Solution

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