Graphene quantum dot formulation for cancer imaging and redox-based drug delivery

Campbell, Elizabeth; Hasan, Tanvir; González-Rodríguez, Roberto; Truly, Tate; Lee, Bong Han; Green, Kayla N.; Akkaraju, Giridhar R.; Naumov, Anton V.

doi:10.1016/j.nano.2021.102408

“…Such modifications could be implemented to improve the biomedical application of GO-conjugated HA. The use of N-doped GQDs in conjunction with HA is discussed by Campbell et al [ 62 ]. The nanocomposite is covalently bound to ferrocene, which selectively targets cancer cells and causes the generation of reactive oxygen species [ 63 ] that are cytotoxic to cells.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Conjugated Carbon Nanomaterials for Enhanced Tumour Targeting Ability

Kearns

¹

,

Camisasca

²

,

Giordani

³

2021

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Hyaluronic acid (HA) has been implemented for chemo and photothermal therapy to target tumour cells overexpressing the CD44+ receptor. HA-targeting hybrid systems allows carbon nanomaterial (CNM) carriers to efficiently deliver anticancer drugs, such as doxorubicin and gemcitabine, to the tumour sites. Carbon nanotubes (CNTs), graphene, graphene oxide (GO), and graphene quantum dots (GQDs) are grouped for a detailed review of the novel nanocomposites for cancer therapy. Some CNMs proved to be more successful than others in terms of stability and effectiveness at removing relative tumour volume. While the literature has been focused primarily on the CNTs and GO, other CNMs such as carbon nano-onions (CNOs) proved quite promising for targeted drug delivery using HA. Near-infrared laser photoablation is also reviewed as a primary method of cancer therapy—it can be used alone or in conjunction with chemotherapy to achieve promising chemo-photothermal therapy protocols. This review aims to give a background into HA and why it is a successful cancer-targeting component of current CNM-based drug delivery systems.

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“…The composite was non-toxic at 1 mg/mL to HEK-293 cells but promoted cytotoxic response in HeLa cells enhanced over time. Besides, therapeutic ROS generation was three times higher than that of single ferrocene [93].…”

Section: Graphene Quantum Dots (Gqds)mentioning

confidence: 86%

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Lagos¹,

Buzzá²,

Bagnato³

et al. 2021

Preprint

8

0

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Within phototherapy, a grand challenge in clinical cancer treatments is to develop a simple, cost-effective, and biocompatible approach to treat this disease using ultra-low doses of light. Carbon-based materials (CBM), such as graphene oxide (GO), reduced GO (r-GO), graphene quantum dots (GQDs), and carbon dots (C-DOTs), are rapidly emerging as a new class of thera-peutic materials against cancer. This mini-review summarizes the progress in lasts years re-garding the applications of CBM in photodynamic (PDT) and photothermal (PTT) therapies for tumor destruction. The current understanding of the performance of modified CBM, hybrids and composites, is also addressed. This approach seeks to achieve an enhanced healing action by im-proving and modulating the properties of CBM to treat various types of cancer. Metal oxides, organic molecules, biopolymers, therapeutic drugs, among others, have been combined with CBM to treat cancer by PDT, PTT, or synergistic therapies.

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“…The composite did not present a significant cytotoxic response at concentrations up to 1 mg/mL for HEK-293 cells, greater than 90% in cell viability. In contrast, the composite action against HeLa cells promoted better cytotoxicity up to 20% after 72 h. Besides, therapeutic ROS generation was three times higher than that of single ferrocene [95]. It is worth noting that the performance of GQDS in PDT might be associated with its specific structural features.…”

Section: Graphene Quantum Dots (Gqds)mentioning

confidence: 96%

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Lagos¹,

Buzzá²,

Bagnato³

et al. 2021

Preprint

4

0

View full text Add to dashboard Cite

Within phototherapy, a grand challenge in clinical cancer treatments is to develop a simple, cost-effective, and biocompatible approach to treat this disease using ultra-low doses of light. Carbon-based materials (CBM), such as graphene oxide (GO), reduced GO (r-GO), graphene quantum dots (GQDs), and carbon dots (C-DOTs), are rapidly emerging as a new class of thera-peutic materials against cancer. This mini-review summarizes the progress in lasts years re-garding the applications of CBM in photodynamic (PDT) and photothermal (PTT) therapies for tumor destruction. The current understanding of the performance of modified CBM, hybrids and composites, is also addressed. This approach seeks to achieve an enhanced healing action by im-proving and modulating the properties of CBM to treat various types of cancer. Metal oxides, organic molecules, biopolymers, therapeutic drugs, among others, have been combined with CBM to treat cancer by PDT, PTT, or synergistic therapies.

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Graphene quantum dot formulation for cancer imaging and redox-based drug delivery

Cited by 39 publications

References 66 publications

Hyaluronic Acid-Conjugated Carbon Nanomaterials for Enhanced Tumour Targeting Ability

Hyaluronic Acid-Conjugated Carbon Nanomaterials for Enhanced Tumour Targeting Ability

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction

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