Graphene Oxide/RhPTH(1-34)/Polylactide Composite Nanofibrous Scaffold for Bone Tissue Engineering

Abstract

Polylactide (PLA) is one of the most promising polymers that has been widely used for the repair of damaged tissues due to its biocompatibility and biodegradability. PLA composites with multiple properties, such as mechanical properties and osteogenesis, have been widely investigated. Herein, PLA/graphene oxide (GO)/parathyroid hormone (rhPTH(1-34)) nanofiber membranes were prepared using a solution electrospinning method. The tensile strength of the PLA/GO/rhPTH(1-34) membranes was 2.64 MPa, nearly 110% higher than that of a pure PLA sample (1.26 MPa). The biocompatibility and osteogenic differentiation test demonstrated that the addition of GO did not markedly affect the biocompatibility of PLA, and the alkaline phosphatase activity of PLA/GO/rhPTH(1-34) membranes was about 2.3-times that of PLA. These results imply that the PLA/GO/rhPTH(1-34) composite membrane may be a candidate material for bone tissue engineering.

Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures

“…For instance, the compression modulus of the Polylactic Acid/GO/Parathyroid Hormone composite scaffold, prepared by Fei et al, reached 2.64 MPa. This is nearly 110% higher compared with the compression modulus (1.26 MPa) of the scaffold without GO [ 53 ]. As confirmed in some studies, enhancing the electrical conductivity of materials can aid in bone tissue repair by inducing calcium influx to promote osteogenic differentiation and biomineralization [ 54 ].…”