Graphene oxide-reinforced poly(2-hydroxyethyl methacrylate) hydrogels with extreme stiffness and high-strength

Pereira, Andreia; Henriques, Patrícia C.; Costa, Paulo; Martins, M. Cristina L.; Magalhães, Fernão D.; Gonçalves, Inês C.

doi:10.1016/j.compscitech.2019.107819

Cited by 31 publications

(27 citation statements)

References 121 publications

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“…In fact, the opposite was shown: YM, UTS and EB tended to increase with higher GO concentrations. This had previously been reported for other GBMcontaining composites [26,43]. The tuning of elasticity may be useful for the application of these composite hydrogels in BCD, which should be stiff/strong enough to withstand various mechanical stresses but must also support deformation and be easily handled and implanted.…”

Section: Discussionmentioning

confidence: 53%

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Using Graphene-Based Materials for Stiff and Strong Poly(ethylene glycol) Hydrogels

Ferreira

Moura

Pereira

et al. 2022

IJMS

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Blood-contacting devices are increasingly important for the management of cardiovascular diseases. Poly(ethylene glycol) (PEG) hydrogels represent one of the most explored hydrogels to date. However, they are mechanically weak, which prevents their use in load-bearing biomedical applications (e.g., vascular grafts, cardiac valves). Graphene and its derivatives, which have outstanding mechanical properties, a very high specific surface area, and good compatibility with many polymer matrices, are promising candidates to solve this challenge. In this work, we propose the use of graphene-based materials as nanofillers for mechanical reinforcement of PEG hydrogels, and we obtain composites that are stiffer and stronger than, and as anti-adhesive as, neat PEG hydrogels. Results show that single-layer and few-layer graphene oxide can strengthen PEG hydrogels, increasing their stiffness up to 6-fold and their strength 14-fold upon incorporation of 4% w/v (40 mg/mL) graphene oxide. The composites are cytocompatible and remain anti-adhesive towards endothelial cells, human platelets and Staphylococcus aureus, similar to neat hydrogels. To the best of our knowledge, this is the first work to report such an increase of the tensile properties of PEG hydrogels using graphene-based materials as fillers. This work paves the way for the exploitation of PEG hydrogels as a backbone material for load-bearing applications.

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Section: Discussionmentioning

confidence: 53%

“…Additionally, studies show that GBM-containing surfaces and polymers have antimicrobial effects [23,25]. Thus, GBM appear to be interesting fillers for improvement of the mechanical properties of hydrogels used in biomedical applications [26,27].…”

Section: Introductionmentioning

confidence: 99%

Using Graphene-Based Materials for Stiff and Strong Poly(ethylene glycol) Hydrogels

Ferreira

Moura

Pereira

et al. 2022

IJMS

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“…Secondly, the observed increase could be attributed to the presence of a large surface area of the adsorbent when the dosage was increased which provided more active binding sites. 35 Nevertheless, as the nano-NiFe 2 O 4 dosage was further increased to 2 g L −1 , the removal efficiency decreased. An excessive concentration of SO 4 − ˙ formed, enabling these radical ions to react with each other, causing a decrease in the SO 4 − ˙ concentration that led to a decreased removal efficiency of CTH.…”

Section: Resultsmentioning

confidence: 99%

UV-enhanced nano-nickel ferrite-activated peroxymonosulfate for the degradation of chlortetracycline hydrochloride in aqueous solution

Zhang

Wang

et al. 2021

RSC Adv.

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“…Of all of GBMs’ features, their exceptional mechanical properties can be highlighted, with graphene being described as the strongest material in the world, as well as their antimicrobial features, , particularly when exposed at the surface. Despite several studies focusing on the mechanical properties of GBMs composites, , as reviewed by Papageorgiou et al., very few use GBMs coatings to promote a mechanical reinforcement. − To the best of our knowledge, coatings of decellularized matrices with GBMs are poorly explored in literature, being reported for the acellular dermal matrix (promoting neovascularization, regeneration of skin tissue and better mechanical performance), decellularized leek samples (revealing an enhanced cell attachment and viability, and decreased stiffness), decellularized sciatic nerve matrices (showing benefits in nerve regeneration), decellularized pulmonary valve (not exhibiting a specific advantage for hemocompatibility), and as a support platform for a dual enzymatic system that promotes anticoagulation …”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Coating Improves the Mechanical and Biological Properties of Decellularized Umbilical Cord Arteries

Pereira

Schneider

Henriques

et al. 2021

ACS Appl. Mater. Interfaces

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The lack of small-diameter vascular grafts (inner diameter <5 mm) to substitute autologous grafts in arterial bypass surgeries has a massive impact on the prognosis and progression of cardiovascular diseases, the leading cause of death globally. Decellularized arteries from different sources have been proposed as an alternative, but their poor mechanical performance and high collagen exposure, which promotes platelet and bacteria adhesion, limit their successful application. In this study, these limitations were surpassed for decellularized umbilical cord arteries through the coating of their lumen with graphene oxide (GO). Placental and umbilical cord arteries were decellularized and perfused with a suspension of GO (C/O ratio 2:1) with ∼1.5 μm lateral size. A homogeneous GO coating that completely covered the collagen fibers was obtained for both arteries, with improvement of mechanical properties being achieved for umbilical cord decellularized arteries. GO coating increased the maximum force in 27%, the burst pressure in 29%, the strain in 25%, and the compliance in 10%, compared to umbilical cord decellularized arteries. The achieved theoretical burst pressure (1960 mmHg) and compliance (13.9%/100 mmHg) are similar to the human saphenous vein and mammary artery, respectively, which are used nowadays as the gold standard in coronary and peripheral artery bypass surgeries. Furthermore, and very importantly, coatings with GO did not compromise the endothelial cell adhesion but decreased platelet and bacteria adhesion to decellularized arteries, which will impact on the prevention of thrombosis and infection, until full re-endothetialization is achieved. Overall, our results reveal that GO coating has an effective role in the improvement of decellularized umbilical cord artery performance, which is a huge step toward their application as a small-diameter vascular graft.

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Graphene oxide-reinforced poly(2-hydroxyethyl methacrylate) hydrogels with extreme stiffness and high-strength

Cited by 31 publications

References 121 publications

Using Graphene-Based Materials for Stiff and Strong Poly(ethylene glycol) Hydrogels

Using Graphene-Based Materials for Stiff and Strong Poly(ethylene glycol) Hydrogels

UV-enhanced nano-nickel ferrite-activated peroxymonosulfate for the degradation of chlortetracycline hydrochloride in aqueous solution

Graphene Oxide Coating Improves the Mechanical and Biological Properties of Decellularized Umbilical Cord Arteries

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