Graphene oxide/poly(acrylic acid)/gelatin nanocomposite hydrogel: Experimental and numerical validation of hyperelastic model

Faghihi, Shahab; Karimi, Alireza; Jamadi, Mahsa; Imani, Rana; Salarian, Reza

doi:10.1016/j.msec.2014.02.015

Cited by 110 publications

(56 citation statements)

References 30 publications

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“…32 Self-assembled graphene oxide-gelatin nanocomposite hydrogels were previously reported by our group, which exhibited a storage modulus of 54.0-114.5 kPa with 98.0-98.5 wt.% water. 34 GO-poly(acrylic acid)-gelatin nanocomposite hydrogels were reported by others, which presented a tensile strength of 150-250 kPa with ~90 wt.% water, 35 and a compressive strength of 7-26 MPa with 29-51 wt.% water content, 36 mainly owing to their strong semi-interpenetrating network comprising chemically cross-linked poly(acrylic acid) and loose gelatin chains as well as the low water contents. UV crosslinked GO-gelatin methacrylate composite hydrogels were also reported, which showed a compressive strength of 91.3-976.7 kPa at a water content of 94.3-94.5 wt.%.…”

Section: Introductionmentioning

confidence: 90%

One-pot synthesis and characterization of reduced graphene oxide–gelatin nanocomposite hydrogels

Piao

Chen

2016

RSC Adv.

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Section: Introductionmentioning

confidence: 90%

One-pot synthesis and characterization of reduced graphene oxide–gelatin nanocomposite hydrogels

Piao

Chen

2016

RSC Adv.

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“…[ 62 ] Faghihi et al evaluated the effects of GO nanosheet content on the linear and nonlinear mechanical properties of poly(acrylic acid) (PAA)/gelatin hydrogels. [ 63 ] The tensile strength and elongation at break of composite hydrogels were signifi cantly increased by the addition of GO nanosheet. These graphene-based composites with high strength and the …”

Section: Utilization Of the Mechanical Properties Of Graphenementioning

confidence: 98%

Graphene‐Based Materials in Regenerative Medicine

Ding

Liu

Fan

2015

Adv Healthcare Materials

143

100

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Graphene possesses many unique properties such as two-dimensional planar structure, super conductivity, chemical and mechanical stability, large surface area, and good biocompatibility. In the past few years, graphene-based materials have risen as a shining star on the path of researchers seeking new materials for future regenerative medicine. Herein, the recent research advances made in graphene-based materials mostly utilizing the mechanical and electrical properties of graphene are described. The most exciting findings addressing the impact of graphene-based materials on regenerative medicine are highlighted, with particular emphasis on their applications including nerve, bone, cartilage, skeletal muscle, cardiac, skin, adipose tissue regeneration, and their effects on the induced pluripotent stem cells. Future perspectives and emerging challenges are also addressed in this Review article.

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“…This stiffening can be regulated by applying an internal force in the cell micro-environment to modulate and control its differentiation and proliferation [29,52,68]. A Neo-Hookean hyperelastic material model is here employed to model nonlinear behavior of hydrogel substrate materials undergoing deformations [17]. Although in this model the stress-strain relationship is initially linear, at a certain threshold the stress-strain curve reaches a plateau.…”

Section: Ecm Materials Behaviormentioning

confidence: 99%

“…Therefore, beside lineage specifications i ∈ {m, s, c, l} (m represents the MSC phenotype), each cell type is also represented by a Maturation Index (MI) described as [47] MI = { t t mat t ≤ t mat 1 t > t mat (17) MI=1 means that a typical cell is fully mature and is ready to differentiate or proliferate if it receives the appropriate mechanical signal. MI=0 indicates a young cell, which means that the cell is not yet able to start the differentiation or proliferation process, even in the presence of the appropriate mechanical stimulus.…”

Section: Cell Differentiation Proliferation and Apoptosismentioning

confidence: 99%

Numerical modeling of cell differentiation and proliferation in force-induced substrates via encapsulated magnetic nanoparticles

Mousavi

Doweidar

2016

Computer Methods and Programs in Biomedicine

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Cell migration, differentiation, proliferation and apoptosis are the main processes in tissue regeneration. Mesenchymal Stem Cells (MSCs) have the potential to differentiate into many cell phenotypes such as tissue-or organ-specific cells to perform special functions. Experimental observations illustrate that differentiation and proliferation of these cells can be regulated according to internal forces induced within their Extracellular matrix (ECM). The process of how exactly they interpret and transduce these signals is not well understood. Therefore, a previously developed three-dimensional (3D) computational model is here extended and employed to study how force-free substrates (FFS) and force-induced substrate (FIS) control cell differentiation and/or proliferation during the mechanosensing process. Consistent with experimental observations, it is assumed that cell internal deformation (a mechanical signal) in correlation with the cell maturation state directly triggers cell differentiation and/or proliferation. ECM is modeled as Neo-Hookean hyperelastic material assuming that cells are cultured within 3D nonlinear hydrogels. In agreement with wellknown experimental observations, the findings here indicate that within neurogenic (0.1-1 kPa), chondrogenic (20-25 kPa) and osteogenic (30-45 kPa) substrates, MSC differentiation and cell proliferation can be precipitated by inducing the substrate with an internal force. Therefore, cells require a longer time to grow and maturate within force-free substrates than withen force-induced substrates. In the instance of MSC differentiation into a compatible phenotype, the magnitude of the net traction force increases within chondrogenic and osteogenic substrates while it reduces within neurogenic substrates. This is consistent with experimental studies and numerical works recently published by the same authors. However, in all cases the magnitude of the net traction force considerably increases at the instant of cell proliferation because of cell-cell interaction. Consequently, the present model provides new perspectives to delineate the role of force-induced substrates in remotely controlling the cell fate during cell-matrix interaction, which open the door for new tissue regeneration methodologies.

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Graphene oxide/poly(acrylic acid)/gelatin nanocomposite hydrogel: Experimental and numerical validation of hyperelastic model

Cited by 110 publications

References 30 publications

One-pot synthesis and characterization of reduced graphene oxide–gelatin nanocomposite hydrogels

One-pot synthesis and characterization of reduced graphene oxide–gelatin nanocomposite hydrogels

Graphene‐Based Materials in Regenerative Medicine

Numerical modeling of cell differentiation and proliferation in force-induced substrates via encapsulated magnetic nanoparticles

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