Graphene oxide nanohybrid that photoreleases nitric oxide

Abstract

Covalent functionalization of graphene oxide with a suitable NO photodonor leads to a nanohybrid material that releases NO under visible light and has potential applications in biomedical research.

Advanced nitric oxide donors: chemical structure of NO drugs, NO nanomedicines and biomedical applications

“…Sortino et al reported a modified graphene oxide (GO) nanoplatform in which GO sheets were covalently functionalized with the NO light-release agent NOP1, and the resulting hybrid nanomedicine (GO-NOP1) released a large amount of NO under visible light. 74 Dr Chen et al constructed a new type of nearinfrared-responsive sandwich nano-drug (GO BNN6). Through π-π stacking, graphene oxide (GO) can absorb NIR light and convert photons into active electrons.…”

Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy

“…However, their use is often limited because of reduced water solubility, photostability, prolonged cutaneous photosensitivity, and low selectivity [ 104 ]. For this region, different approaches have been investigated to combine photosensitizing drugs with other carriers such as liposomes [ 105 ], polymer nanoparticles [ 106 , 107 ], gold nanoparticles [ 108 ], carbon nanotubes [ 109 ], graphene’s [ 110 , 111 ] and carbon nanoparticles [ 112 , 113 ]. Recently, Huang et al [ 114 ] prepared a novel theranostic system based on chlorin e6-conjugated C-dots (C-dots-Ce6).…”

Red light-triggerable nanohybrids of graphene oxide, gold nanoparticles and thermo-responsive polymers for combined photothermia and drug release effects

“…[17][18][19][20] Since hyperthermia enhances the anticancer activity of Cur, 21 photothermal nanosystems are interesting Cur delivery systems. 22 Two-component nanohybrid composites that integrate the properties of GO with nanoparticles or organic molecules were widely reported in the literature 23,24 and investigated for different applications including drug delivery, 25 NO photorelease, 26 and antibacterial 27 activity. Differently, very few examples of three-component GO-based nanosystems are present in the literature.…”