Graphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis

Polydopamine-Modified Zeolite Imidazole Framework Drug Delivery System for Photothermal Chemotherapy of Hepatocellular Carcinoma

“…In general, these results revealed that photochemotherapy could effectively reduce the expression levels of the Ras-Raf-MEK-ERK signal pathway, which greatly contributes to the controlled drug release and synergistic potent anticancer efficiency. Apoptosis is critical for the antiproliferation effect of external factors. , The major regulators involved in apoptosis are caspases and anti/proapoptotic factors, and the final caspase-3 activation leads to apoptosis. − We investigated the effects of SZP on the mRNA expression of apoptosis related genes. Our results proved that in “SZP+L”-treated group, the mRNA expressions of caspase 3, caspase 8, and bax were greatly upregulated (Figure E,F,H), while the mRNA expression of Bcl-2 was downregulated (Figure G).…”

Sources of biases in the in vitro testing of nanomaterials: the role of the biomolecular corona

“…There are several examples in the literature on how GNPs and GO can affect the autophagic cascade 71,[76][77][78][79] depending on the size, shape, surface chemistry, and NP concentration involved, and all this will obviously also depend on the biological model studied. Our results suggest that besides the aforementioned physical-chemical features and experimental protocols, the BMC composition is an additional parameter that has a significant impact, which could, however, be overlooked when using non-representative biological media for cell culture.…”

UV-assisted synthesis of ultra-small GO–Austar for efficient PTT therapeutic architectonic construction

“…Consequently, it has emerged as an excellent platform for constructing biosensors and serving as carriers for various inorganic nanomaterials and organic molecules. 34,35 Interestingly, some works mentioned that carbon nanomaterials including GO and carbon nanotubes could be used as reductants and surfactants to produce metal nanoparticles and semiconductor nanoparticles directly in the absence of conventional reductants and surfactants, which could effectively reduce the use of the toxic reductant and surfactant regents. 36 In this work, we synthesized gold nanostars on the surface of graphene oxide in situ, in which GO could be used as a reductant and surfactant in the formation process of Au nano seeds under UV-light irradiation without adding any other reductants and surfactants.…”

“…Consequently, it has emerged as an excellent platform for constructing biosensors and serving as carriers for various inorganic nanomaterials and organic molecules. 34,35 Interestingly, some works mentioned that carbon nanomaterials including GO and carbon nanotubes could be used as reductants and surfactants to produce metal nanoparticles and semiconductor nanoparticles directly in the absence of conventional reductants and surfactants, which could effectively reduce the use of the toxic reductant and surfactant regents. 36…”