Graphene oxide nanoarchitectures in cancer therapy: Drug and gene delivery, phototherapy, immunotherapy, and vaccine development

Sadeghi, Mohammad Saleh; Sangrizeh, Faezeh Hosseini; Jahani, Negar; Abedin, Mahdi Sadegh; Chaleshgari, Soheila; Ardakan, Alireza Khodaei; Baeelashaki, Reza; Ranjbarpazuki, Golnaz; Rahmanian, Parham; Zandieh, Mohammad Arad; Nabavi, Noushin; Aref, Amir Reza; Salimimoghadam, Shokooh; Rashidi, Mohsen; Rezaee, Aryan; Hushmandi, Kiavash

doi:10.1016/j.envres.2023.117027

Cited by 9 publications

(2 citation statements)

References 189 publications

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“…Among the materials widely used as drug delivery carriers, graphene, especially nanographene oxide (NGO), is increasingly being used as an ideal material to deliver drugs, proteins, small therapeutic molecules, and genes. The reasons for its widespread applications, other than the physical and chemical properties it shares with other carbon-based nanomaterials, include its electrical, optical, and thermal characteristics. − Especially, owing to its aromatic properties, it can reportedly adsorb various aromatic molecules and exhibits good biocompatibility . Additionally, its surface can be easily functionalized.…”

Section: Introductionmentioning

confidence: 99%

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Golgi Apparatus Targeted Graphene Oxide Nanocomposites for Synergistic Chemotherapy, Photothermal Therapy, and Photodynamic Therapy of Metastatic Breast Cancer

Zhou,

Xu,

et al. 2024

ACS Appl. Nano Mater.

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Although metastatic cancer treatment has advanced in current medicine, finding effective treatments remains challenging due to the metastatic mechanism complexity. The integrity of the Golgi apparatus exerts a vital impact on the evolution and metastasis of a tumor. Meanwhile, targeted cancer therapy is a promising approach for treating cancers. Inspired by the research being conducted on the use of targeted cancer therapies, we developed a Golgi apparatustargeted multifunctional graphene nanoplatform (PPG-CS@PTX) for the synergistic chemotherapy/photothermal therapy (PTT)/ photodynamic therapy (PDT) of metastatic breast cancer using single near-infrared (NIR) radiation. Interestingly, the obtained nanoparticles preferentially accumulated at the Golgi apparatus and liberated a considerable amount of paclitaxel in a slightly acidic environment. Subsequently, aided by a single NIR radiation, the Golgi structure was destroyed through synergistic chemotherapy/PTT/PDT. Consequently, migration, invasion, and tumor growth were successfully suppressed in vitro and in vivo. Overall, this study offers a promising strategy for treating metastatic breast cancer through synergistic chemotherapy/PTT/PDT with single NIR irradiation (980 nm).

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Section: Introductionmentioning

confidence: 99%

“…16−18 Especially, owing to its aromatic properties, it can reportedly adsorb various aromatic molecules and exhibits good biocompatibility. 19 Additionally, its surface can be easily functionalized. In our previous studies, the use nimine (NGO-PEG-PEI: PPG) for targeted drug delivery has been reported.…”

Section: Introductionmentioning

confidence: 99%