Although metastatic cancer treatment has advanced in current medicine, finding effective treatments remains challenging due to the metastatic mechanism complexity. The integrity of the Golgi apparatus exerts a vital impact on the evolution and metastasis of a tumor. Meanwhile, targeted cancer therapy is a promising approach for treating cancers. Inspired by the research being conducted on the use of targeted cancer therapies, we developed a Golgi apparatustargeted multifunctional graphene nanoplatform (PPG-CS@PTX) for the synergistic chemotherapy/photothermal therapy (PTT)/ photodynamic therapy (PDT) of metastatic breast cancer using single near-infrared (NIR) radiation. Interestingly, the obtained nanoparticles preferentially accumulated at the Golgi apparatus and liberated a considerable amount of paclitaxel in a slightly acidic environment. Subsequently, aided by a single NIR radiation, the Golgi structure was destroyed through synergistic chemotherapy/PTT/PDT. Consequently, migration, invasion, and tumor growth were successfully suppressed in vitro and in vivo. Overall, this study offers a promising strategy for treating metastatic breast cancer through synergistic chemotherapy/PTT/PDT with single NIR irradiation (980 nm).