Graphene oxide incorporated collagen–fibrin biofilm as a wound dressing material

Deepachitra, R.; Ramnath, V.; Sastry, T. P.

doi:10.1039/c4ra10150b

Cited by 60 publications

(38 citation statements)

References 55 publications

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“…For GO flakes, peaks at 1054 cm −1 were related to the alkoxy group, and those at 1620 and 1728 cm −1 were both attributed to the carboxyl group (COOH) . Infra‐red spectra of the Col scaffold showed amide I, II, III, and A group peaks at 1645, 1549, 1243, and 3315 cm −1 , respectively . For the Col–GO‐90 scaffold, the presence of alkoxy groups was identified by a peak at 1046 cm −1 and the detection of amide groups was also confirmed by observing the related peaks mentioned above.…”

Section: Resultsmentioning

confidence: 87%

“…Figure shows the FT‐IR spectra of GO flakes, Col, and Col–GO‐90 scaffolds with the corresponding reduced sample. For GO flakes, peaks at 1054 cm −1 were related to the alkoxy group, and those at 1620 and 1728 cm −1 were both attributed to the carboxyl group (COOH) . Infra‐red spectra of the Col scaffold showed amide I, II, III, and A group peaks at 1645, 1549, 1243, and 3315 cm −1 , respectively .…”

Section: Resultsmentioning

confidence: 99%

“…The presence of oxygen‐containing functional groups on the surface of GO can prevent irreversible agglomeration . Recently, it has been demonstrated that GO has good biocompatibility and can enhance the mechanical properties of scaffolds and promote cellular behaviors, such as cell attachment and cell differentiation in various tissue engineering applications . As an example, Lee et al stated that graphene could increase cardiomyogenic differentiation of human embryonic stem cells (hESCs) compared to that of culture on glass or Matrigel, possibly owing to the graphene nanoroughness.…”

Section: Introductionmentioning

confidence: 99%

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Electroactive graphene oxide‐incorporated collagen assisting vascularization for cardiac tissue engineering

Norahan

Amroon

Ghahremanzadeh

et al. 2018

J Biomedical Materials Res

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The application of a cardiac patch over the epicardial surface has shown positive effects in protecting cardiac function postinfarction. Electroactive patches could enhance electrical signal propagation among cardiac cells. In the present study, an electrically active composite of collagen and graphene oxide (Col-GO) was fabricated as a cardiac patch. Col scaffolds were fabricated using a freeze-drying method and coated covalently with GO. Some scaffolds were also reduced by a reduction agent to restore the high conductivity of GO. GO was shown to be a single layer with suitable lateral size for biological application. The Col-GO scaffolds contained randomly oriented interconnected pores with appropriate pore sizes of 120-138 AE 8 μm. GO flakes were also well distributed in the pore walls. By increasing the GO concentration, the tensile strength of the scaffolds was enhanced from 75 kPa for Col-GO-5 to 162 kPa for Col-GO-90. Young modulus also followed the same trend. Electrical conductivity of the scaffolds was in the range of semi-conductive materials (~10 −4 S/m), which is suitable for cardiac tissue engineering applications. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay indicated no toxic effects on human umbilical vein endothelial cells (HUVECs) after 96 h. Also, a 10-days degradation product of the samples was compatible with HUVECs. Reduced scaffolds supported neonatal cardiomyocyte adhesion and upregulated the expression of the cardiac genes, including Cx43, Actin4, and Trpt-2 than their nonconductive counterparts. The obtained results confirmed the angiogenic properties of reduced Go-containing materials for cardiovascular applications where angiogenesis plays an important role, especially postinfarction.

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electroactive graphene oxide‐incorporated collagen assisting vascularization for cardiac tissue engineering

Norahan

Amroon

Ghahremanzadeh

et al. 2018

J Biomedical Materials Res

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“…In a related application, collagen-fi brin (CF) biocomposite fi lms incorporated with GO (CFGO) were prepared for would healing. [ 159 ] The existence of GO enhanced the mechanical strength of collagen/fi brin fi lms. Faster wound healing was found in CFGO treated rats compared with those without GO, which indicated that graphene-based materials enhanced wound healing and might be used on more clinical wounds of various animal models before their applications on human beings.…”

Section: Skin Regenerationmentioning

confidence: 99%

Graphene‐Based Materials in Regenerative Medicine

Ding

Liu

Fan

2015

Adv Healthcare Materials

141

102

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Graphene possesses many unique properties such as two-dimensional planar structure, super conductivity, chemical and mechanical stability, large surface area, and good biocompatibility. In the past few years, graphene-based materials have risen as a shining star on the path of researchers seeking new materials for future regenerative medicine. Herein, the recent research advances made in graphene-based materials mostly utilizing the mechanical and electrical properties of graphene are described. The most exciting findings addressing the impact of graphene-based materials on regenerative medicine are highlighted, with particular emphasis on their applications including nerve, bone, cartilage, skeletal muscle, cardiac, skin, adipose tissue regeneration, and their effects on the induced pluripotent stem cells. Future perspectives and emerging challenges are also addressed in this Review article.

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“…Wound dressings prepared from sodium carboxymethyl cellulose and rGO reduced biofilm formation caused by S. aureus and P. aeruginosa significantly in vitro . Collagen–fibrin composite films incorporated with GO were biocompatible and enhanced wound healing . Furthermore, the application of metal‐based NPs in wound dressings has been reported to prevent the wound from bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

Development, characterization, and in vitro evaluation of water soluble poloxamer/pluronic‐mastic gum‐gum acacia‐based wound dressing

Buyana

Aderibigbe

Ray

et al. 2019

J of Applied Polymer Sci

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Bacterial infections are serious complications associated with wounds. Wounds can become chronic due to bacterial infections. In this research, lyophilized wound dressings were prepared from poloxamer, pluronic, mastic gum, and gum acacia. The wound dressings were loaded with metal‐based nanoparticles and carbon‐based materials. They exhibited effective antibacterial activity, water‐soluble, biodegradable with the capability to absorb large amounts of wound exudates. The bandages were analyzed using Fourier transform infrared spectroscopy, scanning electron microscopy/energy‐dispersive X‐ray spectroscopy, thermogravimetric analysis, and transmission electron microscopy followed by porosity and water uptake. TEM confirmed the successful incorporation of the metal‐based NPs and carbon‐based materials into the wound dressings. The TGA confirmed that the wound dressings are thermally stable. The wound dressings were also characterized by a high uptake of water to form a gel which was soluble in water indicating their useful application for wounds with large wound exudate, sensitive and damaged skin. The unique properties of the wound dressings indicate that they are potential materials for the treatment of chronic wounds in patients with sensitive skin. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48728.

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Graphene oxide incorporated collagen–fibrin biofilm as a wound dressing material

Abstract: GO was incorporated in the collagen and fibrin composite film (CFGO), these films were used as wound dressing material on the experimental wounds of rats and the efficacy of CFGO was studied using conventional methods (schematic illustration).

Cited by 60 publications

References 55 publications

Electroactive graphene oxide‐incorporated collagen assisting vascularization for cardiac tissue engineering

Electroactive graphene oxide‐incorporated collagen assisting vascularization for cardiac tissue engineering

Graphene‐Based Materials in Regenerative Medicine

Development, characterization, and in vitro evaluation of water soluble poloxamer/pluronic‐mastic gum‐gum acacia‐based wound dressing

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