Graphene oxide-driven interfacial coupling in laser 3D printed PEEK/PVA scaffolds for bone regeneration

Feng, Pei; Jia, Jiye; Peng, Shuping; Yang, Wenjing; Bin, Shizhen; Shuai, Cijun

doi:10.1080/17452759.2020.1719457

Cited by 76 publications

(54 citation statements)

References 42 publications

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“…Scaffold-based bone tissue engineering is an alternative approach with potential to overcome major limitations of biological grafts such as pain and morbidity in donor sites, limited quantity and availability, deep infection and hematoma risk (autografting), rejection, diseases transmission, limited supply (allografting), and ethical problems (xenografting). Scaffolds are three-dimensional (3D) biocompatible and biodegradable porous physical substrates for cells to attach, proliferate, and differentiate[ 1 - 3 ]. They must have adequate mechanical properties, geometry and morphology, surface characteristics and must be easily sterilized[ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Effect of Carbon Nanomaterials Reinforcing Poly(ε-Caprolactone) Printed Scaffolds for Bone Repair Applications

Hou

Wang

Bartolo

2024

IJB

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Scaffolds, three-dimensional (3D) substrates providing appropriate mechanical support and biological environments for new tissue formation, are the most common approaches in tissue engineering. To improve scaffold properties such as mechanical properties, surface characteristics, biocompatibility and biodegradability, different types of fillers have been used reinforcing biocompatible and biodegradable polymers. This paper investigates and compares the mechanical and biological behaviors of 3D printed poly(ε-caprolactone) scaffolds reinforced with graphene (G) and graphene oxide (GO) at different concentrations. Results show that contrary to G which improves mechanical properties and enhances cell attachment and proliferation, GO seems to show some cytotoxicity, particular at high contents.

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Section: Introductionmentioning

confidence: 99%

Investigating the Effect of Carbon Nanomaterials Reinforcing Poly(ε-Caprolactone) Printed Scaffolds for Bone Repair Applications

Hou

Wang

Bartolo

2024

IJB

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“…Recent advances have demonstrated that inducing the bone formation to restore the normal bone homeostasis is efficient for osteoporosis treatment 1 . Although osteogenesis induced by biological materials has gained much attention, classic methods are still applied in the studies of osteogenic differentiation of MSCs 2‐5 . Human umbilical cord‐derived mesenchymal stem cells (hUC‐MSCs), a stem cell population, possess many advantages relative to other cell sources, 6 including easily isolated, abundantly supply, 7 low immune rejection, 8 self‐renewing ability and multipotency 9 .…”

Section: Introductionmentioning

confidence: 99%

Linc02349 promotes osteogenesis of human umbilical cord‐derived stem cells by acting as a competing endogenous RNA for miR‐25‐3p and miR‐33b‐5p

et al. 2020

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Objectives: Increasing evidences suggest that inducing mesenchymal stem cells to differentiate into osteoblasts has been as an especially important component in the prevention and therapy for degenerative bone disease. Here, we identify a novel lncRNA, linc02349, which increases significantly during osteogenic differentiation. Materials and methods:Human umbilical cord-derived stem cells (hUC-MSCs) and dental pulp mesenchymal stem cells were used. Overexpression and knockdown of linc02349 in cell lines were generated using lentiviral-mediated gene delivery method.Bioinformatics prediction, Ago2-RIP assay and dual-luciferase reporter system were employed to examine miRNA which interacts with linc02349. The RNA FISH assay was performed to identify the subcelluar location of linc02349. Alizarin Red S staining, ALP staining and qPCR were applied to identify the osteogenic differentiation. The potential linc02349-regulated genes, miR-25-3p and miR-33b-5p, were explored by ChIP, RIP and Western blotting assays. Micro-CT was used to measure the osteogenic content in bone formation assay in vivo. Results: Linc02349 overexpression improves osteogenic differentiation by in vitroand in vivo analysis. Mechanistically, linc02349 acts as a molecular sponge for miR-25-3p and miR-33b-5p to control expression abundance of SMAD5 and Wnt10b,

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“…Feng et al [ 269 ] focused their work on reducing the degradation rate of PVA. They blended PVA with PEEK, a non-biodegradable polymer, which successfully reduced the degradation rate.…”

Section: 3d Printed Scaffolds With Carbon-based Nanomaterialsmentioning

confidence: 99%

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

et al. 2020

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Bone possesses an inherent capacity to fix itself. However, when a defect larger than a critical size appears, external solutions must be applied. Traditionally, an autograft has been the most used solution in these situations. However, it presents some issues such as donor-site morbidity. In this context, porous biodegradable scaffolds have emerged as an interesting solution. They act as external support for cell growth and degrade when the defect is repaired. For an adequate performance, these scaffolds must meet specific requirements: biocompatibility, interconnected porosity, mechanical properties and biodegradability. To obtain the required porosity, many methods have conventionally been used (e.g., electrospinning, freeze-drying and salt-leaching). However, from the development of additive manufacturing methods a promising solution for this application has been proposed since such methods allow the complete customisation and control of scaffold geometry and porosity. Furthermore, carbon-based nanomaterials present the potential to impart osteoconductivity and antimicrobial properties and reinforce the matrix from a mechanical perspective. These properties make them ideal for use as nanomaterials to improve the properties and performance of scaffolds for bone tissue engineering. This work explores the potential research opportunities and challenges of 3D printed biodegradable composite-based scaffolds containing carbon-based nanomaterials for bone tissue engineering applications.

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Graphene oxide-driven interfacial coupling in laser 3D printed PEEK/PVA scaffolds for bone regeneration

Cited by 76 publications

References 42 publications

Investigating the Effect of Carbon Nanomaterials Reinforcing Poly(ε-Caprolactone) Printed Scaffolds for Bone Repair Applications

Investigating the Effect of Carbon Nanomaterials Reinforcing Poly(ε-Caprolactone) Printed Scaffolds for Bone Repair Applications

Linc02349 promotes osteogenesis of human umbilical cord‐derived stem cells by acting as a competing endogenous RNA for miR‐25‐3p and miR‐33b‐5p

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

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