Graphene oxide decorated with zinc oxide nanoflower, silver and titanium dioxide nanoparticles: fabrication, characterization, DNA interaction, and antibacterial activity

El‐Shafai, Nagi M.; El‐Khouly, Mohamed E.; El‐Kemary, Maged; Ramadan, Mohamed; Eldesoukey, Ibrahim E.; Masoud, Mamdouh S.

doi:10.1039/c8ra09788g

Cited by 95 publications

(34 citation statements)

References 72 publications

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“…A multicomposite of GO, CoFe 2 O 4 , and Ag nanoparticles was also manufactured to disinfect water contaminated with E. coli and S. aureus, leading to almost complete inhibition at 12 µg/mL [96]. GO decorated with Ag, TiO 2 , and ZnO nanostructures has been prepared via ultrasonication and casting, and the antibacterial activity of the nanocomposite was tested against Gram-positive S. aureus and B. anthracoides and Gram-negative E. coli and P. multocida [98]. Figure 10 shows SEM images of GO, Ag, GO-Ag, GO-TiO 2 -ZnO, and GO-Ag-TiO 2 -ZnO nanocomposites.…”

Section: Multicomponent Nanocompositesmentioning

confidence: 99%

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Antibacterial Action of Nanoparticle Loaded Nanocomposites Based on Graphene and Its Derivatives: A Mini-Review

Díez‐Pascual

2020

IJMS

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Bacterial infections constitute a severe problem in various areas of everyday life, causing pain and death, and adding enormous costs to healthcare worldwide. Besides, they cause important concerns in other industries, such as cloth, food packaging, and biomedicine, among others. Despite the intensive efforts of academics and researchers, there is lack of a general solutions to restrict bacterial growth. Among the various approaches, the use of antibacterial nanomaterials is a very promising way to fight the microorganisms due to their high specific surface area and intrinsic or chemically incorporated antibacterial action. Graphene, a 2D carbon-based ultra-thin biocompatible nanomaterial with excellent mechanical, thermal, and electrical properties, and its derivatives, graphene oxide (GO) and reduced graphene oxide (rGO), are highly suitable candidates for restricting microbial infections. However, the mechanisms of antimicrobial action, their cytotoxicity, and other issues remain unclear. This mini-review provides select examples on the leading advances in the development of antimicrobial nanocomposites incorporating inorganic nanoparticles and graphene or its derivatives, with the aim of providing a better understanding of the antibacterial properties of graphene-based nanomaterials.

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Section: Multicomponent Nanocompositesmentioning

confidence: 99%

“…Right: Inhibitory zones of GO-Ag-TiO2@ZnO nanocomposite against S. aureus, B. anthracoides and Gram-negative E. coli and P. multocida. Adapted from Ref [98],. with permission from the Royal Society of Chemistry, 2019.…”

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confidence: 99%

Antibacterial Action of Nanoparticle Loaded Nanocomposites Based on Graphene and Its Derivatives: A Mini-Review

Díez‐Pascual

2020

IJMS

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“…According to the reported studies, the antibacterial mechanisms of the ZGF include not only the direct contact between ZnO nanoparticles and bacteria but the release of zinc ions and the production of reactive oxygen species (ROS) [13,34]. In addition, because of high absorption capacity for Zn 2+ , GO is also able to become a storage place for Zn 2+ released from ZnO nanoparticles and increases the permeability of the cell membrane by contacting with negatively charged bacteria, which eventually lead to the deformation of the cell membrane and leakage of intracellular substances [35,36]. In addition, some researchers have proposed that ZnO, as a semiconductor, can generate electron-hole pairs and ROS under the irradiation of UV, which also leads to protein peroxidation, lipid peroxidation and DNA damage [36,37].…”

Section: Characterization Of Zno/go-gelatin Fibersmentioning

confidence: 99%

“…In addition, because of high absorption capacity for Zn 2+ , GO is also able to become a storage place for Zn 2+ released from ZnO nanoparticles and increases the permeability of the cell membrane by contacting with negatively charged bacteria, which eventually lead to the deformation of the cell membrane and leakage of intracellular substances [35,36]. In addition, some researchers have proposed that ZnO, as a semiconductor, can generate electron-hole pairs and ROS under the irradiation of UV, which also leads to protein peroxidation, lipid peroxidation and DNA damage [36,37]. The unique two-dimensional sheet layer of GO will enhance the electron transfer rate and reduce the electron-hole pair recombination, which also makes ZnO/GO nanocomposites exert better antibacterial activities [38].…”

Section: Characterization Of Zno/go-gelatin Fibersmentioning

confidence: 99%

Preparation of Electrospun Gelatin Mat with Incorporated Zinc Oxide/Graphene Oxide and Its Antibacterial Activity

Chen

et al. 2020

Molecules

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Current wound dressings have poor antimicrobial activities and are difficult to degrade. Therefore, biodegradable and antibacterial dressings are urgently needed. In this article, we used the hydrothermal method and side-by-side electrospinning technology to prepare a gelatin mat with incorporated zinc oxide/graphene oxide (ZnO/GO) nanocomposites. The resultant fibers were characterized by field emission environment scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffractometry (XRD) and Fourier transform infrared spectroscopy (FTIR). Results indicated that the gelatin fibers had good morphology, and ZnO/GO nanocomposites were uniformly dispersed on the fibers. The loss of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) viability were observed to more than 90% with the incorporation of ZnO/GO. The degradation process showed that the composite fibers completely degraded within 7 days and had good controllable degradation characteristics. This study demonstrated the potential applicability of ZnO/GO-gelatin mats with excellent antibacterial properties as wound dressing material.

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“…Recently, several studies have focused on the nano-silver oxide–graphene and nano- ZnO–graphene complexes because they have better antimicrobial and antifungal activities than those of GO alone [22,23,24,25,26,27,28]. The application of silver/zinc oxide/reduced graphene oxide (Ag/ZnO/rGO) nanocomposites in bacterial detection and sterilization has also been studied [29,30]. The Ag/ZnO/rGO nanocomposite has been found to function in bacterial detection and sterilization, opening up a new angle to study the antibacterial efficacy of different composites of nanomaterials and GO.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Property of Composites of Reduced Graphene Oxide with Nano-Silver and Zinc Oxide Nanoparticles Synthesized Using a Microwave-Assisted Approach

Hsueh

Hsieh

Chiu

et al. 2019

IJMS

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Graphene oxide (GO) composites with various metal nanoparticles (NPs) are attracting increasing interest owing to their broad scope in biomedical applications. Here, microwave-assisted chemical reduction was used to deposit nano-silver and zinc oxide NPs (Ag and ZnO NPs) on the surface of reduced GO (rGO) at the following weight percentages: 5.34% Ag/rGO, 7.49% Ag/rGO, 6.85% ZnO/rGO, 16.45% ZnO/rGO, 3.47/34.91% Ag/ZnO/rGO, and 7.08/15.28% Ag/ZnO/rGO. These materials were tested for antibacterial activity, and 3.47/34.91% Ag/ZnO/rGO and 7.08/15.28% Ag/ZnO/rGO exhibited better antibacterial activity than the other tested materials against the gram-negative bacterium Escherichia coli K12. At 1000 ppm, both these Ag/ZnO/rGO composites had better killing properties against both E. coli K12 and the gram-positive bacterium Staphylococcus aureus SA113 than Ag/rGO and ZnO/rGO did. RedoxSensor flow cytometry showed that 3.47/34.91% Ag/ZnO/rGO and 7.08/15.28% Ag/ZnO/rGO decreased reductase activity and affected membrane integrity in the bacteria. At 100 ppm, these two composites affected membrane integrity more in E. coli, while 7.08/15.28% Ag/ZnO/rGO considerably decreased reductase activity in S. aureus. Thus, the 3.47/34.91% and 7.08%/15.28% Ag/ZnO/rGO nanocomposites can be applied not only as antibacterial agents but also in a variety of biomedical materials such as sensors, photothermal therapy, drug delivery, and catalysis, in the future.

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Graphene oxide decorated with zinc oxide nanoflower, silver and titanium dioxide nanoparticles: fabrication, characterization, DNA interaction, and antibacterial activity

Abstract: The fabrication, characterization, and antibacterial activity of novel nanocomposites based on graphene oxide (GO) nanosheets decorated with silver, titanium dioxide nanoparticles, and zinc oxide nanoflowers were examined.

Cited by 95 publications

References 72 publications

Antibacterial Action of Nanoparticle Loaded Nanocomposites Based on Graphene and Its Derivatives: A Mini-Review

Antibacterial Action of Nanoparticle Loaded Nanocomposites Based on Graphene and Its Derivatives: A Mini-Review

Preparation of Electrospun Gelatin Mat with Incorporated Zinc Oxide/Graphene Oxide and Its Antibacterial Activity

Antibacterial Property of Composites of Reduced Graphene Oxide with Nano-Silver and Zinc Oxide Nanoparticles Synthesized Using a Microwave-Assisted Approach

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