Graphene Oxide Catalyzed One‐pot Synthesis of Pyrimido[4,5‐b]quinolinone‐2,4‐diones and their Biological Evaluation

Abstract

A simple and highly efficient method for the synthesis of 5‐aryl‐pyrimido quinoline 2,4‐diones has been demonstrated. Graphene oxide (GO) has proved to be a new class of carbocatalyst for the synthesis of pyrimido[4,5‐b]quinolinone‐2,4‐diones through one‐pot three component reaction using aromatic amines, aldehydes, and barbituric acid. The antimicrobial activity of the synthesized compounds was examined for the first time. The effects e. g. reaction temperature, catalyst amount, reaction time, the molar ratio of reactants were investigated. The GO could easily be recovered and reused upto 5th run without loss of its catalytic activity.

Synthesis, crystal structure and in silico studies of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones

“…To synthesise novel 2,4-dimethoxy-THPQs, a multi-component strategy was utilised which is used to generate a wide variety of heterocyclic compounds with multifaceted medicinal uses. 24 Previous methods utilised various catalyst such as nano-[Fe 3 O 4 @SiO 2 @R-NHMe 2 ][H 2 PO 4 ], 25 graphene oxide, 26 MIL-100(Cr)/NHEtN(CH 2 PO 3 H 2 ) 2 , 27 choline chloride/oxalic acid, 28 IR-MOF-3-ILOAc-Fe(acac) 3 , 29 N , N -diethyl- N -sulfoethanaminium chloride 30 and nano-[Fe 3 O 4 @SiO 2 / N -propyl-1-(thiophen-2-yl)ethanimine][ZnCl 2 ] 31 to synthesised 2,4-dimethoxy-THPQs. Catalyst-free synthesis of THPQs were also reported using absolute ethanol, 32 acetic acid, 33–35 and electrolysis in presence of alcohol.…”

Decorated Magnetic Nanocatalyst with Trinitriloacetic Acid as a Heterogeneous Catalyst used in the Synthesis of Pyrimido[4,5]quinoline‐2,4‐diones

“…Also in compare to acidic catalysts, such as acetic acid, [56] p ‐toluensulfonic acid (TsOH), [57] oxalic acid dihydrate:proline (LTTM), [58] and graphene oxide (GO), [59] which have been used for preparation of the similar products through the same reaction, Fe 3 O 4 @SiO 2 ‐NH‐NTAA require a lower reaction temperature in addition to lower mol %, higher turnover number (TON) and turnover frequency (TOF), and higher reaction yield.…”

Recent Developments on Catalyst‐Free, Visible‐Light‐Triggered Synthesis of Heterocyclic Scaffolds and Their Mechanistic Study

“…Pyrimido-quinolinone derivatives are an essential group of heterocyclic scaffolds that possess biological activities such as anti-malarial, anti-microbial, anti-bacterial and anti-tumor [66] etc.…”