Graphene Oxide-Based Biosensors

Zeng, Lingwen; Cao, Shi‐Lin; Yin, Hang; Xiong, Jun; Lin, Donghai

doi:10.5772/intechopen.78222

Cited by 7 publications

(4 citation statements)

References 27 publications

(32 reference statements)

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“…The peculiar photochemical characteristics of GO make it a suitable sensor component toward a plethora of possible analytes, such as water and VOCs [ 43 ], glucose [ 44 ], antibiotics [ 45 ], and phytohormones [ 46 ], to name just a few. Its large surface area, flexibility, thermal stability, optical transparency and ease of production, coupled to nonconductive hydrophilic properties and proneness to functionalization, attracted a wide interest in the biosensing field [ 47 , 48 ]. Several recent advances in the use of GO fluorescence quenching ability for the detection of viruses, bacteria and cancer cells ( Figure 4 ) are reviewed in the following sections.…”

Section: Fluorescence-based Go Sensors For Diagnosticsmentioning

confidence: 99%

Biosensing Systems Based on Graphene Oxide Fluorescence Quenching Effect

Battisti

Samal²,

Puppi

2023

Micromachines

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Graphene oxide (GO) is a versatile material obtained by the strong oxidation of graphite. Among its peculiar properties, there is the outstanding ability to significantly alter the fluorescence of many common fluorophores and dyes. This property has been exploited in the design of novel switch-ON and switch-OFF fluorescence biosensing platforms for the detection of a plethora of biomolecules, especially pathological biomarkers and environmental contaminants. Currently, novel advanced strategies are being developed for therapeutic, diagnostic and theranostic approaches to widespread pathologies caused by viral or bacterial agents, as well as to cancer. This work illustrates an overview of the most recent applications of GO-based sensing systems relying on its fluorescence quenching effect.

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Section: Fluorescence-based Go Sensors For Diagnosticsmentioning

confidence: 99%

Biosensing Systems Based on Graphene Oxide Fluorescence Quenching Effect

Battisti

Samal²,

Puppi

2023

Micromachines

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“…23 Graphene oxide combines some of the excellent properties of graphene with the advantage of the high hydrophilicity compared with hydrophobic graphene, which gives user-friendliness for the synthesis, preparation, and construction of new-generation biosensors. [24][25][26] However, due to the insertion of the oxygen functionalities and the disruption of the sp 2 system of graphene to sp 2 -sp 3 of GO, the latter exhibits lower conductivity. 28 As a result, GO is usually used after its reduction to rGO.…”

Section: Impact Statementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is graphene the rock upon which new era continuous glucose monitors could be built?

Papanikolaou

Simos

Spyrou

et al. 2022

Exp Biol Med (Maywood)

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Diabetes mellitus’ (DM) prevalence worldwide is estimated to be around 10% and is expected to rise over the next decades. Monitoring blood glucose levels aims to determine whether glucose targets are met to minimize the risk for the development of symptoms related to high or low blood sugar and avoid long-term diabetes complications. Continuous glucose monitoring (CGMs) systems emerged almost two decades ago and have revolutionized the way diabetes is managed. Especially in Type 1 DM, the combination of a CGM with an insulin pump (known as a closed-loop system or artificial pancreas) allows an autonomous regulation of patients’ insulin with minimal intervention from the user. However, there is still an unmet need for high accuracy, precision and repeatability of CGMs. Graphene was isolated in 2004 and found immediately fertile ground in various biomedical applications and devices due to its unique combination of properties including its high electrical conductivity. In the last decade, various graphene family nanomaterials have been exploited for the development of enzymatic and non-enzymatic biosensors to determine glucose in biological fluids, such as blood, sweat, and so on. Although great progress has been achieved in the field, several issues need to be addressed for graphene sensors to become a predominant material in the new era of CGMs.

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“…In recent years, graphene has become a common material for sensors due to its great optical, electronic, and magnetic properties. GO, a popular modifier of the graphene family, has reactive oxygen functional groups making it even more popular in the field of biosensors, and it is usually modified with other materials to improve its electrochemical properties [ 84 , 85 ].…”

Section: Detection Of Organic Matter (Cod)mentioning

confidence: 99%

Nanomaterials for electrochemical detection of pollutants in water: A review

et al. 2021

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The survival of living beings, including humanity, depends on a continuous supply of clean water. However, due to the development of industry, agriculture, and population growth, an increasing number of wastewaters is discarded, and the negative effects of such actions are clear. The first step in solving this situation is the collection and monitoring of pollutants in water bodies to subsequently facilitate their treatment. Nonetheless, traditional sensing techniques are typically laboratory‐based, leading to potential diminishment in analysis quality. In this paper, the most recent developments in micro‐ and nano‐electrochemical devices for pollutant detection in wastewater are reviewed. The devices reviewed are based on a variety of electrodes and the sensing of three different categories of pollutants: nutrients and phenolic compounds, heavy metals, and organic matter. From these electrodes, Cu, Co, and Bi showed promise as versatile materials to detect a grand variety of contaminants. Also, the most commonly used material is glassy carbon, present in the detection of all reviewed analytes.

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Graphene Oxide-Based Biosensors

Cited by 7 publications

References 27 publications

Biosensing Systems Based on Graphene Oxide Fluorescence Quenching Effect

Biosensing Systems Based on Graphene Oxide Fluorescence Quenching Effect

Is graphene the rock upon which new era continuous glucose monitors could be built?

Nanomaterials for electrochemical detection of pollutants in water: A review

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