Graphene oxide as a new anthropogenic stress factor - multigenerational study at the molecular, cellular, individual and population level of Acheta domesticus

Dziewięcka, Marta; Flasz, Barbara; Rost‐Roszkowska, Magdalena; Kędziorski, Andrzej; Kochanowicz, Anna; Augustyniak, Maria

doi:10.1016/j.jhazmat.2020.122775

Cited by 27 publications

(15 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Then, each type of GO was mixed with the ground food and given to animals during the cytotoxicity assessment. A detailed food preparation method and the food composition can be found elsewhere [26,27].…”

Section: Experimental Modelmentioning

confidence: 99%

“…The samples were prepared in the same conditions and intentionally "coded" to focus on the physical-chemical-biological relationships rather than the material's origin. Based on our several years of experience with GO, we used the Acheta domesticus model organism with known physiology and reactions under stress conditions [26][27][28][29][30][31][32][33][34]. The following hypotheses were verified to resolve the relationship between the chemical composition and morphology of GO samples and selected cytotoxicity markers at the cellular level:…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Structure–Properties–Cytotoxicity Interplay: A Crucial Pathway to Determining Graphene Oxide Biocompatibility

Dziewięcka

Pawlyta

Majchrzycki

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Interest in graphene oxide nature and potential applications (especially nanocarriers) has resulted in numerous studies, but the results do not lead to clear conclusions. In this paper, graphene oxide is obtained by multiple synthesis methods and generally characterized. The mechanism of GO interaction with the organism is hard to summarize due to its high chemical activity and variability during the synthesis process and in biological buffers’ environments. When assessing the biocompatibility of GO, it is necessary to take into account many factors derived from nanoparticles (structure, morphology, chemical composition) and the organism (species, defense mechanisms, adaptation). This research aims to determine and compare the in vivo toxicity potential of GO samples from various manufacturers. Each GO sample is analyzed in two concentrations and applied with food. The physiological reactions of an easy model Acheta domesticus (cell viability, apoptosis, oxidative defense, DNA damage) during ten-day lasting exposure were observed. This study emphasizes the variability of the GO nature and complements the biocompatibility aspect, especially in the context of various GO-based experimental models. Changes in the cell biomarkers are discussed in light of detailed physicochemical analysis.

show abstract

Section: Experimental Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Structure–Properties–Cytotoxicity Interplay: A Crucial Pathway to Determining Graphene Oxide Biocompatibility

Dziewięcka

Pawlyta

Majchrzycki

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Autophagy, a process of cellular self‐destruction in response to stress, starvation or infection, was usually related to apoptosis. But existing research only detected low intensity autophagy during multigenerational exposure (Babczynska et al, 2020; Dziewiecka et al, 2020), and the role of autophagy in multigenerational effects still need further study. In addition, due to the limitation in available evidence, it is largely unclear whether different pollutants including metals, organics, and particulate pollutants share the exact cellular mechanisms during controlling transgenerational toxicity.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

A review of transgenerational and multigenerational toxicology in the in vivo model animal Caenorhabditis elegans

Zhao

Chen

Wang

et al. 2022

J of Applied Toxicology

View full text Add to dashboard Cite

A large number of pollutants existing in the environment can last for a long time, and their potential toxic effects can transfer from parents to their offspring. Thus, it is necessary to investigate the toxicity of environmental pollutants across multigenerations and the underlying mechanisms in organisms. Due to its short life cycle and sensitivity to environmental exposures, Caenorhabditis elegans is an important animal model for toxicity assessment of environmental pollutants across multigenerations. In this review, we introduced the transgenerational and multigenerational toxicity caused by various environmental pollutants in C. elegans. Moreover, we discussed the underlying mechanisms for the observed transgenerational and multigenerational toxicity of environmental contaminants in C. elegans.

show abstract

“…GOs decreased the lifespan, reduced the number of larvae per female, and the hatching time was shorter in the first and third generations. Interestingly, the second generation did not show the same pattern of changes as the first and third generations [ 77 ].…”

Section: Developmental Carbon Nanotoxicitymentioning

confidence: 99%

Reproductive and Developmental Nanotoxicity of Carbon Nanoparticles

et al. 2022

View full text Add to dashboard Cite

The presented review aims to summarize the knowledge regarding the reproductive and developmental toxicity of different types of carbon nanoparticles, such as graphene, graphene oxide, multi- and single-walled nanotubes, fullerenes, and nanodiamonds. Carbon nanoparticles have unique chemical and physical properties that make them an excellent material that can be applied in many fields of human activity, including industry, food processing, the pharmaceutical industry, or medicine. Although it has a high degree of biocompatibility, possible toxic effects on different tissue types must also be taken into account. Carbon nanoparticles are known to be toxic to the respiratory, cardiovascular, nervous, digestive system, etc., and, according to current studies, they also have a negative effect on reproduction and offspring development.

show abstract

Graphene oxide as a new anthropogenic stress factor - multigenerational study at the molecular, cellular, individual and population level of Acheta domesticus

Cited by 27 publications

References 47 publications

The Structure–Properties–Cytotoxicity Interplay: A Crucial Pathway to Determining Graphene Oxide Biocompatibility

The Structure–Properties–Cytotoxicity Interplay: A Crucial Pathway to Determining Graphene Oxide Biocompatibility

A review of transgenerational and multigenerational toxicology in the in vivo model animal Caenorhabditis elegans

Reproductive and Developmental Nanotoxicity of Carbon Nanoparticles

Contact Info

Product

Resources

About