Graphene-ophicalcite heterogeneous composite sponge for rapid hemostasis

Wu, Bingxin; Du, Fanglin; Wenjing, A; Liu, Fang; Liu, Yichun; Zheng, Weitao; Li, Guofeng; Wang, Xing

doi:10.1016/j.colsurfb.2022.112596

Cited by 7 publications

(2 citation statements)

References 38 publications

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“…In reference to a previous method, hemolysis assays were conducted to assess the hemocompatibility of CSM. [30] First, blood was drawn from the ear marginal vein of New Zealand rabbits using a sodium citrate (9:1) anticoagulated vacuum blood collection tube. Next, 50 mg of the sample was deposited in a centrifuge tube, and 5 ml of saline was added.…”

Section: Hemolysis Experimentsmentioning

confidence: 99%

The fabrication and hemostasis of controlled-size chitosan microspheres：A preliminary research

Zhou,

Wen,

Xia

et al. 2024

Preprint

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Extreme bleeding can make therapy challenging or even fatal. Even though several commercial homeostatic medicines have favorable clinical results, there is still a desire to discover materials that are effective, bio-safe, inexpensive, and simple to produce. In this study, regulated and uniformly sized chitosan microspheres (CSM) were fabricated using a simple process and assessed as hemostatic agents. In addition, the diameter criteria for optimal hemostatic effects were evaluated. Precipitation and coaxial airflow shear technique were used to fabricate CSM with a controlled and homogeneous particle size. Secondly, scanning electron microscope and N2 adsorption-desorption isotherm characterization, water absorption experiments, and in vitro coagulation evaluation demonstrated that the CSM produced in this experiment have a porous structure, a high specific surface area, and a high-water absorption capacity. The hemostatic effect was investigated using a rabbit blood coagulation experiment in vitro. To further examine the hemostatic effect using an arterial/venous bleeding model in rats. The results were superior to those in the blank control group. The hemostatic effect is related to the diameter of the microspheres. In these experiments, large diameter chitosan microspheres possessed superior hemostatic effect. Hence, these novel CSM show considerable potential for use in hemostatic events and demonstrated a diameter-dependent hemostatic effect.

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Section: Hemolysis Experimentsmentioning

confidence: 99%

The fabrication and hemostasis of controlled-size chitosan microspheres：A preliminary research

Zhou,

Wen,

Xia

et al. 2024

Preprint

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show abstract

“…The study aimed to evaluate the hemostatic effect of C/SA-based dressings using a rat femoral artery injury model [58,68]. Forty-five Wistar rats were randomly assigned to 5 groups.…”

Section: In Vivo Model Of Femoral Artery Hemorrhagementioning

confidence: 99%

Comprehensive Assessment of Collagen/Sodium Alginate-Based Sponges as Hemostatic Dressings

Sun,

Shen,

et al. 2024

Molecules

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In our search for a biocompatible composite hemostatic dressing, we focused on the design of a novel biomaterial composed of two natural biological components, collagen and sodium alginate (SA), cross-linked using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) and oxidized sodium alginate (OSA). We conducted a series of tests to evaluate the physicochemical properties, acute systemic toxicity, skin irritation, intradermal reaction, sensitization, cytotoxicity, and in vivo femoral artery hemorrhage model. The results demonstrated the excellent biocompatibility of the collagen/sodium alginate (C/SA)-based dressings before and after crosslinking. Specifically, the femoral artery hemorrhage model revealed a significantly shortened hemostasis time of 132.5 ± 12.82 s for the EDC/NHS cross-linked dressings compared to the gauze in the blank group (hemostasis time of 251.43 ± 10.69 s). These findings indicated that C/SA-based dressings exhibited both good biocompatibility and a significant hemostatic effect, making them suitable for biomedical applications.

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Effects of Different Culture Conditions and Growth States on the Structure and Hemostatic Properties of Coscinodiscus sp.

He,

Li,

Liu

et al. 2024

J. Ocean Univ. China

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Graphene-ophicalcite heterogeneous composite sponge for rapid hemostasis

Cited by 7 publications

References 38 publications

The fabrication and hemostasis of controlled-size chitosan microspheres：A preliminary research

The fabrication and hemostasis of controlled-size chitosan microspheres：A preliminary research

Comprehensive Assessment of Collagen/Sodium Alginate-Based Sponges as Hemostatic Dressings

Effects of Different Culture Conditions and Growth States on the Structure and Hemostatic Properties of Coscinodiscus sp.

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